Exploring the role of gut microbiota in migraine risk: a two-sample Mendelian randomization study

References

• International Headache Society. Headache classification committee of the international headache society (IHS) the international classification of headache disorders. Cephalalgia. 2018;38(1):1–211.
   Google Scholar
• GBD 2016 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the global burden of disease study 2016. Lancet. 2017;390(10100):1211–1259. doi: 10.1016/S0140-6736(17)32154-2.
   PubMed Web of Science ®Google Scholar
• Safiri S, Pourfathi H, Eagan A, et al. Global, regional, and national burden of migraine in 204 countries and territories, 1990–2019. Pain. 2022;163(2):e293–e309. doi: 10.1097/j.pain.0000000000002275.
   PubMed Web of Science ®Google Scholar
• Selby G, Lance JW. Observations on 500 cases of migraine and allied vascular headache. J Neurol Neurosurg Psychiatry. 1960;23(1):23–32. doi: 10.1136/jnnp.23.1.23.
   PubMed Web of Science ®Google Scholar
• Ding JH, Jin Z, Yang XX, et al. Role of gut microbiota via the gut-liver-brain axis in digestive diseases. World J Gastroenterol. 2020;26(40):6141–6162. doi: 10.3748/wjg.v26.i40.6141.
   PubMed Web of Science ®Google Scholar
• Banks WA. Evidence for a cholecystokinin gut-brain axis with modulation by bombesin. Peptides. 1980;1(4):347–351. doi: 10.1016/0196-9781(80)90013-3.
   PubMed Web of Science ®Google Scholar
• Faraco G, Brea D, Garcia-Bonilla L, et al. Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response. Nat Neurosci. 2018;21(2):240–249. doi: 10.1038/s41593-017-0059-z.
   PubMed Web of Science ®Google Scholar
• Sampson TR, Debelius JW, Thron T, et al. Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson’s disease. Cell. 2016;167(6):1469–1480. doi: 10.1016/j.cell.2016.11.018.
   PubMed Web of Science ®Google Scholar
• Bhattacharjee S, Lukiw WJ. Alzheimer’s disease and the microbiome. Front Cell Neurosci. 2013;7:153. doi: 10.3389/fncel.2013.00153.
   PubMed Web of Science ®Google Scholar
• Borre YE, Moloney RD, Clarke G, et al. The impact of microbiota on brain and behavior: mechanisms & therapeutic potential. Adv Exp Med Biol. 2014;817:373–403. doi: 10.1007/978-1-4939-0897-4_17.
   PubMed Web of Science ®Google Scholar
• Konjevod M, Nikolac Perkovic M, Sáiz J, et al. Metabolomics analysis of microbiota-gut-brain axis in neurodegenerative and psychiatric diseases. J Pharm Biomed Anal. 2021;194:113681. doi: 10.1016/j.jpba.2020.113681.
   PubMed Web of Science ®Google Scholar
• Kong G, Cao KL, Judd LM, et al. Microbiome profiling reveals gut dysbiosis in a transgenic mouse model of Huntington’s disease. Neurobiol Dis. 2020;135:104268. doi: 10.1016/j.nbd.2018.09.001.
   PubMed Web of Science ®Google Scholar
• Wasser CI, Mercieca EC, Kong G, et al. Gut dysbiosis in Huntington’s disease: associations among gut microbiota, cognitive performance and clinical outcomes. Brain Commun. 2020;2(2):fcaa110. doi: 10.1093/braincomms/fcaa110.
   PubMedGoogle Scholar
• Zhang YG, Wu S, Yi J, et al. Target intestinal microbiota to alleviate disease progression in amyotrophic lateral sclerosis. Clin Ther. 2017;39(2):322–336. doi: 10.1016/j.clinthera.2016.12.014.
   PubMed Web of Science ®Google Scholar
• Scheperjans F, Aho V, Pereira PA, et al. Gut microbiota are related to Parkinson’s disease and clinical phenotype. Mov Disord. 2015;30(3):350–358. doi: 10.1002/mds.26069.
   PubMed Web of Science ®Google Scholar
• Milosevic I, Vujovic A, Barac A, et al. Gut-Liver axis, gut microbiota, and its modulation in the management of liver diseases: a review of the literature. Int J Mol Sci. 2019;20(2):395. doi: 10.3390/ijms20020395.
   PubMed Web of Science ®Google Scholar
• Dai YJ, Wang HY, Wang XJ, et al. Potential beneficial effects of probiotics on human migraine headache: a literature review. Pain Phys. 2017;2(20;2):E251–e5. doi: 10.36076/ppj.2017.E255.
   Google Scholar
• Sekula P, Del Greco MF, Pattaro C, et al. Mendelian randomization as an approach to assess causality using observational data. J Am Soc Nephrol. 2016;27(11):3253–3265. doi: 10.1681/ASN.2016010098.
   PubMed Web of Science ®Google Scholar
• Smith GD, Ebrahim S. ‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol. 2003;32(1):1–22. doi: 10.1093/ije/dyg070.
   PubMed Web of Science ®Google Scholar
• Davey Smith G, Hemani G. Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Hum Mol Genet. 2014;23(R1):R89–R98. doi: 10.1093/hmg/ddu328.
   PubMed Web of Science ®Google Scholar
• Sanderson E, Smith GD, Windmeijer F, et al. Corrigendum to: an examination of multivariable mendelian randomization in the single-sample and two-sample summary data settings. Int J Epidemiol. 2020;49(3):1057–1057. doi: 10.1093/ije/dyaa101.
   PubMed Web of Science ®Google Scholar
• Cai J, Li X, Wu S, et al. Assessing the causal association between human blood metabolites and the risk of epilepsy. J Transl Med. 2022;20(1):437. doi: 10.1186/s12967-022-03648-5.
   PubMed Web of Science ®Google Scholar
• Li P, Wang H, Guo L, et al. Association between gut microbiota and preeclampsia-eclampsia: a two-sample mendelian randomization study. BMC Med. 2022;20(1):443. doi: 10.1186/s12916-022-02657-x.
   PubMed Web of Science ®Google Scholar
• Burgess S, Small DS, Thompson SG. A review of instrumental variable estimators for mendelian randomization. Stat Methods Med Res. 2017;26(5):2333–2355. doi: 10.1177/0962280215597579.
   PubMed Web of Science ®Google Scholar
• Kurilshikov A, Medina-Gomez C, Bacigalupe R, et al. Large-scale association analyses identify host factors influencing human gut microbiome composition. Nat Genet. 2021;53(2):156–165. doi: 10.1038/s41588-020-00763-1.
   PubMed Web of Science ®Google Scholar
• Gormley P, Anttila V, Winsvold BS, et al. Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nat Genet. 2016;48(8):856–866. doi: 10.1038/ng.3598.
   PubMed Web of Science ®Google Scholar
• Wei Z, Yang B, Tang T, et al. Gut microbiota and risk of five common cancers: a univariable and multivariable mendelian randomization study. Cancer Med. 2023;12(9):10393–10405. doi: 10.1002/cam4.5772.
   PubMed Web of Science ®Google Scholar
• Pierce BL, Ahsan H, Vanderweele TJ. Power and instrument strength requirements for mendelian randomization studies using multiple genetic variants. Int J Epidemiol. 2011;40(3):740–752. doi: 10.1093/ije/dyq151.
   PubMed Web of Science ®Google Scholar
• Pierce BL, Burgess S. Efficient design for mendelian randomization studies: subsample and 2-sample instrumental variable estimators. Am J Epidemiol. 2013;178(7):1177–1184. doi: 10.1093/aje/kwt084.
   PubMed Web of Science ®Google Scholar
• Burgess S, Foley CN, Allara E, et al. A robust and efficient method for mendelian randomization with hundreds of genetic variants. Nat Commun. 2020;11(1):376. doi: 10.1038/s41467-019-14156-4.
   PubMed Web of Science ®Google Scholar
• Burgess S, Bowden J, Fall T, et al. Sensitivity analyses for robust causal inference from mendelian randomization analyses with multiple genetic variants. Epidemiology. 2017;28(1):30–42. doi: 10.1097/EDE.0000000000000559.
   PubMed Web of Science ®Google Scholar
• Greco MF, Minelli C, Sheehan NA, et al. Detecting pleiotropy in mendelian randomisation studies with summary data and a continuous outcome. Stat Med. 2015;34(21):2926–2940. doi: 10.1002/sim.6522.
   PubMed Web of Science ®Google Scholar
• Bowden J, Davey Smith G, Burgess S. Mendelian randomization with invalid instruments: effect estimation and bias detection through egger regression. Int J Epidemiol. 2015;44(2):512–525. doi: 10.1093/ije/dyv080.
   PubMed Web of Science ®Google Scholar
• Chen Y, Zhou J, Wang L. Role and mechanism of gut microbiota in human disease. Front Cell Infect Microbiol. 2021;11:625913. doi: 10.3389/fcimb.2021.625913.
   PubMed Web of Science ®Google Scholar
• Morais LH, Schreiber H, Mazmanian SK. The gut microbiota-brain axis in behaviour and brain disorders. Nat Rev Microbiol. 2021;19(4):241–255. doi: 10.1038/s41579-020-00460-0.
   PubMed Web of Science ®Google Scholar
• Thaiss CA, Zmora N, Levy M, et al. The microbiome and innate immunity. Nature. 2016;535(7610):65–74. doi: 10.1038/nature18847.
   PubMed Web of Science ®Google Scholar
• Gao J, Xu K, Liu H, et al. Impact of the gut microbiota on intestinal immunity mediated by tryptophan metabolism. Front Cell Infect Microbiol. 2018;8:13. doi: 10.3389/fcimb.2018.00013.
   PubMed Web of Science ®Google Scholar
• Ghavami A, Khorvash F, Heidari Z, et al. Effect of synbiotic supplementation on migraine characteristics and inflammatory biomarkers in women with migraine: results of a randomized controlled trial. Pharmacol Res. 2021;169:105668. doi: 10.1016/j.phrs.2021.105668.
   PubMed Web of Science ®Google Scholar
• de Roos NM, van Hemert S, Rovers JMP, et al. The effects of a multispecies probiotic on migraine and markers of intestinal permeability-results of a randomized placebo-controlled study. Eur J Clin Nutr. 2017;71(12):1455–1462. doi: 10.1038/ejcn.2017.57.
   PubMed Web of Science ®Google Scholar
• Karlsson FH, Tremaroli V, Nookaew I, et al. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature. 2013;498(7452):99–103. doi: 10.1038/nature12198.
   PubMed Web of Science ®Google Scholar
• Goodrich JK, Waters JL, Poole AC, et al. Human genetics shape the gut microbiome. Cell. 2014;159(4):789–799. doi: 10.1016/j.cell.2014.09.053.
   PubMed Web of Science ®Google Scholar
• Yücel M, Kotan D, Gurol Çiftçi G, et al. Serum levels of endocan, claudin-5 and cytokines in migraine. Eur Rev Med Pharmacol Sci. 2016;20(5):930–936.
   PubMed Web of Science ®Google Scholar
• Martami F, Razeghi Jahromi S, Togha M, et al. The serum level of inflammatory markers in chronic and episodic migraine: a case-control study. Neurol Sci. 2018;39(10):1741–1749. doi: 10.1007/s10072-018-3493-0.
   PubMed Web of Science ®Google Scholar
• Cámara-Lemarroy CR, Rodriguez-Gutierrez R, Monreal-Robles R, et al. Gastrointestinal disorders associated with migraine: a comprehensive review. World J Gastroenterol. 2016;22(36):8149–8160. doi: 10.3748/wjg.v22.i36.8149.
   PubMed Web of Science ®Google Scholar
• McLean MH, Dieguez D, Jr., Miller LM, et al. Does the microbiota play a role in the pathogenesis of autoimmune diseases? Gut. 2015;64(2):332–341. doi: 10.1136/gutjnl-2014-308514.
   PubMed Web of Science ®Google Scholar
• de Vos WM, de Vos EA. Role of the intestinal microbiome in health and disease: from correlation to causation. Nutr Rev. 2012;70(Suppl 1):S45–S56. doi: 10.1111/j.1753-4887.2012.00505.x.
   PubMed Web of Science ®Google Scholar
• Cai J, He L, Wang H, et al. Genetic liability for prescription opioid use and risk of cardiovascular diseases: a multivariable mendelian randomization study. Addiction. 2022;117(5):1382–1391. doi: 10.1111/add.15767.
   PubMed Web of Science ®Google Scholar
• Sanderson E. Multivariable mendelian randomization and mediation. Cold Spring Harb Perspect Med. 2021;11(2):a038984. doi: 10.1101/cshperspect.a038984.
   PubMed Web of Science ®Google Scholar
• VanderWeele TJ, Tchetgen Tchetgen EJ, Cornelis M, et al. Methodological challenges in mendelian randomization. Epidemiology. 2014;25(3):427–435. doi: 10.1097/EDE.0000000000000081.
   PubMed Web of Science ®Google Scholar