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Research Article

Endotoxin-Mediated Intestinal Damage: Protective Effect of Capsaicin in the Rat

Pages 736-742 | Published online: 08 Jul 2009

References

  • Deitch EA, Berg R, Specian R. Endotoxin promotes the translocation of bacteria from the gut. Arch Surg 1987; 122: 185–90.
  • De Gaudio AR, Padelletti MB, Leoni M, Tani R, Bartoloni Saint Omer F, Calzolari A, et al. Induzione della translocazione batterica nel ratto mediante dosi minime di endotossina. Minerva Anestesiol 1993; 59: 419–25.
  • Boughton-Smith NK, Hutchenson I, Whittle BJR. Relationship betwen Paf-acether and thromboxane A2 biosynthesis in endotoxin-induced intestinal damage in the rat. Prostaglandins 1989; 38: 319–33.
  • Fantone JC, Ward PA. Role of oxygen demand free radicals and metabolites in leukocyte dependent inflammatory reactions. Am J Pathol 1982; 107: 397–418.
  • Evangelista S, Meli A. Influence of capsaicin-sensitive fibers on experimentally-induced colitis in rats. J Pharm Pharmacol 1989; 4: 574–5.
  • Castagliuolo I, LaMont JT, Letourneau R, Kelly C, O’Keane JC, Jaffer A, et al. Neuronal involvement in the intestinal effects of Clostridium difficile toxin A and Vibrio cholerae enterotoxin in rat ileum. Gastroenterology 1994; 107: 657–65.
  • Holzer P. Capsaicin: cellular targets, mechanism of a action and selectivity for thin sensory neurons. Pharmacol Rev 1991; 43: 143–201.
  • Holzer P, Lippe ITh. Stimulation of afferent nerve endings by intragastric capsaicin protects against ethanol-induced damage of gastric mucosa. Neuroscience 1988; 27: 981–7.
  • Howard RT. Microbes and their pathogenicity. In: Simmons RL, Howard RJ, editors. Surgical infectious disease. New York: Appleton-Century-Crofts; 1982. p. 11–28.
  • Deitch EA, Specain RD, Berg RD. Endotoxin-induced bacterial translocation and mucosal permeability: role of xantine oxidase, complement activation, and macrophage products. Crit Care Med 1991; 19: 785–91.
  • Hutcheson IR, Whittle BJR, Boughton-Smith NK. Role of nitric oxide in maintaining vascular integrity in endotoxin-induced acute intestinal damage in the rat. Br J Pharmacol 1990; 101: 815–20.
  • Lundgren O. Studies on blood flow distribution and countercurrent exchange in the small intestine. Acta Physiol Scand 1967; Suppl 303: 1–42.
  • Holzer P. Peptidergic sensory neurons in the control of vascular functions: mechanism and significance in the cutaneous and splanchnic vascular beds. Rev Physiol Biochem Pharmacol 1992; 121: 49–146.
  • Uddman R, Edvinsson L, Ekbald E, Ekblad E, Hakanson R, Sundler F. Calcitonin gene related peptide (CGRP): perivascular distribution and vasodilatory effects. Regul Pept 1986; 15: 1–23.
  • Holzer P, Bucsics A, Lembeck F. Distribution of capsaicin-sensitive nerves fibers containing substance P in cutaneous and visceral tissues of the rat. Neurosci Lett 1982; 31: 253–7.
  • Hokfelt T, Elde R, Johansson O, Luft R, Nilsson G, Arimura A. Immunohistochemical evidence for separate populations of somatostatin-containing and substance P containing primary sensory afferent neurons in the rat. Neuroscience 1976; 1: 131–6.
  • Dalsgaard CJ, Haegerstraus A, Theodorsson-Norheim E, Brodin E, Hokfelt T. Neurokinin A-like immunoreactivity rat primary sensory neurons: coexistence with substance P. Histochemistry 1985; 83: 37–79.
  • Long NC, Frevert CW, Shore SA. Capsaicin pretreatment increases inflammatory response to intratracheal instillation of endotoxin in rats. Regul Pept 1993; 46: 208–10.
  • Jarreau PH, D’Ortho MP, Boyer V, Harf A, Macquin-Mavier I. Effects of capsaicin on the airway responses to inhaled endotoxin in the guinea pig. Am J Respir Crit Care Med 1994; 149: 128–33.
  • Pothoulakis C, Castagliuolo I, LaMont JT, Jaffer A, O’Keane JC. CP-96,345, a substance P antagonist, inhibits rat intestinal responses to Clostridium difficile toxin A but not Cholera toxin. Proc Natl Acad Sci 1994; 91: 947–51.
  • Keates AC, Castigliuolo I, Qiu BS, Nikulasson S, Sengupta A, Pothoulakis C. CGRP upregulation in dorsal root ganglia and ileal mucosa during Clostridium difficile toxin A induced enteritis. Am J Physiol 1998; 37: G196–202.
  • Bret-Dibat JL, Kent S, Couraud JY, Crempnon C, Dantzer R. A behaviorally active dose of lipopolysaccharide increases sensory neuropeptides levels in mouse spinal cord. Neurosci Lett 1994; 173: 205–9.

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