Antineutrophil and Pancreatic Autoantibodies in First-Degree Relatives of Patients with Inflammatory Bowel Disease

REFERENCES

• Saxon A, Shanahan F, Landers C, Ganz T, Targan S. A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease. J Allergy Clin Immunol 1990; 86:202–10.
   Google Scholar
• Stoecker W, Otte M, Ulrich S, Stocker K, Jantschek G. Autoantibodies against the exocrine pancreas and against intestinal goblet cells in the diagnosis of Crohn’s disease and ulcerative colitis. Dtsch Med Wochenschr 1984;109:1963–9.
   Google Scholar
• Stocker W, Otte M, Scriba PC. Immunopathogenesis of Crohn’s disease. Dtsch Med Wochenschr 1984;109:1984–6.
   PubMed Web of Science ®Google Scholar
• Stocker W, Otte M, Ulrich S, Normann D, Finkbeiner H, Stocker K, et al. Autoimmunity to pancreatic juice in Crohn’s disease. Results of an autoantibody screening in patients with chronic inflammatory bowel disease. Scand J Gastroenterol 1987;Suppl 139:41–52.
   Google Scholar
• Duerr RH, Targan SR, Landers CJ, Sutherland LR, Shanahan F. Anti-neutrophil cytoplasmic antibodies in ulcerative colitis. Comparison with other colitides/diarrheal illnesses. Gastroenterology 1991;100:1590–6.
   Google Scholar
• Shanahan F, Duerr RH, Rotter IJ, Yang H, Sutherland LR, Mc Elree C, et al. Neutrophil autoantibodies in ulcerative colitis: Familial aggregation and genetic heterogeneity. Gastroenterology 1992;103:456–61.
   Google Scholar
• Seibold F, Slametschka D, Gregor M, Weber P. Neutrophil autoantibodies: a genetic marker in primary sclerosing cholangitis and ulcerative colitis. Gastroenterology 1994;107:532–6.
   PubMed Web of Science ®Google Scholar
• Lee JC, Lennard-Jones JE, Cambridge G. Antineutrophil anti-bodies in familial inflammatory bowel disease. Gastroenterology 1995;108:428–33.
   PubMed Web of Science ®Google Scholar
• Monteleone G, Doldo P, Marasco R, Parello T, Imeneo M, De Medici A, et al. Perinuclear neutrophil autoantibodies (p- ANCA) in unaffected relatives of patients with ulcerative colitis (UC). Suggestions against familial aggregation. Gut 1994;35 Suppl 4:A31.
   Google Scholar
• Reumaux D, Delecourt L, Colombel JF, Noel LH, Duthilleul P, Cortot A, et al. Anti-neutrophil cytoplasmic autoantibodies in relatives of patients with ulcerative colitis [letter; comment]. Gastroenterology 1992;103:1706.
   PubMed Web of Science ®Google Scholar
• Papo M, Quer JC, Pastor MR, Garcia Pardo G, Prats E, Mirapeix E, et al. Antineutrophil cytoplasmatic antibodies in relatives of patients with inflammatory bowel disease. Am J Gastroenterol 1996;91:1512–5.
   Google Scholar
• Yang P, Jarnerot G, Danielsson D, Tysk C, Lindberg E. P- ANCA in monozygotic twins with inflammatory bowel disease. Gut 1995;36:887–90.
   Google Scholar
• Broekroelofs J, Mulder AH, Nelis GF, Westerveld BD, Tervaert JW, Kallenberg CG, et al. Anti-neutrophil cytoplasmic antibodies (ANCA) in sera from patients with inflammatory bowel disease (IBD). Relation to disease pattern and disease activity. Dig Dis Sci 1994;39:545–9.
   PubMed Web of Science ®Google Scholar
• Colombel JF, Reumaux D, Duthilleul P, Noel LH, Gower- Rousseau C, Paris JC, et al. Antineutrophil cytoplasmic autoantibodies in inflammatory bowel diseases. Gastroenterol Clin Biol 1992;16:656–60.
   Google Scholar
• Patel RT, Stokes R, Birch D, Ibbotson J, Keighley MR. Influence of total colectomy on serum antineutrophil cytoplasmic antibodies in inflammatory bowel disease. Br J Surg 1994; 81:724–6.
   Google Scholar
• Cambridge G, Rampton D, Stevens DR, Ibodson J, Keighley MR. Antineutrophil antibodies in inflammatory bowel disease: prevalence and diagnostic role. Gut 1992;33:668–74.
   Google Scholar
• Kim WH, Choi PM, Landers CJ, Targan SR. Role of antineutrophil cytoplasmic antibodies in an ethnically distinct population: Korean patients with ulcerative colitis. Am J Gastroenterol 1995;90:1953–8.
   PubMed Web of Science ®Google Scholar
• Seibold F, Weber P, Jenss H, Wiedmann KH. Antibodies to a trypsin sensitive pancreatic antigen in chronic inflammatory bowel disease: specific markers for a subgroup of patients with Crohn’s disease. Gut 1991;32:1192–7.
   PubMed Web of Science ®Google Scholar
• Goischke EM, Zilly W. Clinical importance of organ-specific antibodies in ulcerative colitis and Crohn disease. Z Gastroenterol 1992;30:319–24.
   PubMed Web of Science ®Google Scholar
• Romas E, Paspaliaris B, d’Apice AJ, Elliot PR. Autoantibodies to neutrophil cytoplasmic (ANCA) and endothelial cell surface antigens (AECA) in chronic inflammatory bowel disease. Aust NZ J Med 1992;22:652–9.
   Google Scholar
• Yang H, Rotter JI, Toyoda H, Landers C, Tyran D, Mac Elree CK, et al. Ulcerative colitis: a genetically heterogeneous disorder defined by genetic (HLA class II) and subclinical (antineutrophil cytoplasmic antibodies) markers. J Clin Invest 1993; 92:1080–4.
   Google Scholar
• Duerr RH, Targan SR, Landers CJ, La Russo NF, Lindsay KL, Wiesner RH, et al. Neutrophil cytoplasmic antibodies: a link between primary sclerosing cholangitis and ulcerative colitis. Gastroenterology 1991;100:1385–91.
   Google Scholar
• Oudkerk Pool M, Ellerbroek PM, Ridwan BU, Goldschmeding R, von Blomberg BM, Pena AS, et al. Serum antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease are mainly associated with ulcerative colitis. A correlation study between perinuclear antineutrophil cytoplasmic autoantibodies and clinical parameters, medical, and surgical treatment. Gut 1993;34:46–50.
   Google Scholar
• Seibold F, Mork H, Tanza S, Müller A, Holzhüter C, Weber P, et al. Pancreatic autoantibodies in Crohn’s disease: a family study. Gut 1997;40:481–4.
   Google Scholar
• Broekroelofs J, Mulder AH, Nelis GF, Westerveld BD, Tervaert JW, Kallenberg CG. Anti-neutrophil cytoplasmic antibodies (ANCA) in sera from patients with inflammatory bowel disease (IBD). Relation to disease pattern and disease activity. Dig Dis Sci 1994;39:545–9.
   PubMed Web of Science ®Google Scholar
• Colombel JF, Reumaux D, Duthilleul P, Noel LH, Gower- Rousseau C, Paris JC, et al. Antineutrophil cytoplasmic autoantibodies in inflammatory bowel diseases. Gastroenterol Clin Biol 1992;16:656–60.
   Google Scholar
• Halbwachs-Mecarelli L, Nusbaum P, Noel LH, Reumaux D, Erlinger S, Grunfeld JP, et al. Antineutrophil cytoplasmic antibodies (ANCA) directed against cathepsin G in ulcerative colitis, Crohn’s disease and primary sclerosing cholangitis. Clin Exp Immunol 1992;90:79–84.
   Google Scholar
• Mulder AH, Broekroelofs J, Horst G, Limburg PC, Nelis GF, Kallenberg CG. Anti-neutrophil cytoplasmic antibodies (ANCA) in inflammatory bowel disease: characterization and clinical correlates. Clin Exp Immunol 1994;95:490–7.
   PubMed Web of Science ®Google Scholar
• Skogh T, Peen E. Lactoferrin, anti-lactoferrin antibodies and inflammatory disease. Adv Exp Med Biol 1993;336:533–8.
   PubMedGoogle Scholar
• Schumacher G, Kollberg B, Sandstedt B, Ljungh A, Nassberger L. Circulating granulocyte antibodies in first attacks of colitis. Scand J Gastroenterol 1995;30:157–63.
   PubMed Web of Science ®Google Scholar
• Weiss J, Elsbach P, Olsson I, Odeberg H. Purification and characterization of a potent bactericidal and membrane active protein from the granules of human polymorphonuclear leukocytes. J Biol Chem 1978;253:2664–72.
   PubMed Web of Science ®Google Scholar
• Folwaczny C, Noehl N, Jochum M, Loeschke K, Fricke H. p- ANCA in inflammatory bowel disease recognize different target antigens. Gastroenterology 1997;M2:A974.
   Google Scholar
• Walsmley RS, Zhao MH, Hamilton MI, Brownlee A, Chapman P, Pounder RE, et al. Antineutrophil cytoplasm autoantibodies against bactericidal/permeability increasing protein in inflammatory bowel disease. Gut 1997;40:105–9.
   PubMed Web of Science ®Google Scholar
• Stoffel MP, Csernok E, Gross WL. Target antigen for antineutrophil cytoplasmatic antibodies in inflammatory bowel disease. Scand J Gastroenterol 1996;31:943–4.
   Google Scholar
• Marra MN, Wilde CG, Collins MS, Snable JL, Thornton MB, Scott RW. The role of bactericidal/permeability-increasing protein as a natural inhibitor of bacterial endotoxin. J Immunol 1992;148:532–7.
   PubMed Web of Science ®Google Scholar
• Monajemi H, Meenan J, Lamping R, Obradov DO, Radema S, Trown PW. Inflammatory bowel disease is associated with increased mucosal levels of bactericidal/permeability increasing protein. Gastroenterology 1996;110:733–9.
   PubMed Web of Science ®Google Scholar
• Ammons WS, Kohn FR, Kung AH. Protective effects of an N- terminal fragment of bactericidal/permeability-increasing protein in rodent models of gram-negative sepsis: role of bactericidal properties. J Infect Dis 1994;170:1473–82.
   Google Scholar
• Stoffel MP, Csernok E, Herzberg C, Johnson T, Carroll SF, Gross WL. Anti-neutrophil cytoplasmatic antibodies (ANCA) directed against bactericidal/permeability increasing protein (BPI): a new seromarker for inflammatory bowel disease and associated disorders. Clin Exp Immunol 1996;104:54–9.
   PubMed Web of Science ®Google Scholar
• Fricke H, Birkhofer A, Folwaczny C, Scriba PC. Characterization of antigens from the human exocrine pancreatic tissue (Pag) relevant as target antigens for autoantibodies in Crohn’s disease. Gastroenterology 1996;110:A46.
   Web of Science ®Google Scholar
• Duerr RH, Targan SR, Landers CJ, LaRusso NF, Lindsay KL, Wiesner RH, et al. Neutrophil cytoplasmic autoantibodies: a link between primary sclerosing cholangitis and ulcerative colitis. Gastroenterology 1991;100:1385–91.
   PubMed Web of Science ®Google Scholar
• Saxon A, Shanhan F, Landers C, Ganz T, Targan S. A distinct subset of antineutrophil cytoplasmic autoantibodies is associated with inflammatory bowel disease. J Allergy Clin Immunol 1990; 86:202–10.
   Google Scholar