Advanced search
Publication Cover
Scandinavian Journal of Gastroenterology Volume 33, 1998 - Issue 12
Submit an article Journal homepage
8
Views
5
CrossRef citations to date
0
Altmetric
Research Article

Extracts of Helicobacter pylori Reduce Gastric Mucosal Blood Flow through a VacA- and CagA-Independent Pathway in Rats

C. ATUMA, L. ENGSTRAND, L. HOLM
Pages 1256-1261 | Published online: 08 Jul 2009

References

  • DeCross AJ. The role of Helicobacter pylori in acid-peptic disease. Am J Med Sci 1993;306:381–92.
  • Dixon MF. Pathophysiology of Helicobacter pylori infection. Scand J Gastroenterol 1994;29 Suppl 201:7–10.
  • Sipponen P, Hyvärinen H. Role of Helicobacter pylori in the pathogenesis of gastritis, peptic ulcer and gastric cancer. Scand J Gastroenterol 1993;28 Suppl 196:3–6.
  • Mégraud F. Toxic factors of Helicobacter pylori. Eur J Gastroenterol Hepatol 1994;6 Suppl 1:S5–10.
  • Xiang Z, Censini S, Bayeli PF, Telford JL, Figura N, Rappuoli R, et al. Analysis of expression of CagA and VacA virulence factors in 43 strains of Helicobacter pylori reveals that clinical isolates can be divided into two major types and that CagA is not necessary for expression of the vacuolating cytotoxin. Infect Immun 1995;63:94–8.
  • Yoshida N, Granger N, Evans DJ Jr, Evans DG, Graham DY, Anderson DC, et al. Mechanisms involved in Helicobacter pylori-induced inflammation. Gastroenterology 1993;105:1431–40.
  • Kurose I, Granger DN, Evans DJ Jr, Evans DG, Graham DY, Miyasaka M, et al. Helicobacter pylori-induced microvascular protein leakage in rats: role of neutrophils, mast cells, and platelets. Gastroenterology 1994;107:70–9.
  • Ernst PB, Crowe SE, Reyes VE. How does Helicobacter pylori cause mucosal damage? The inflammatory response. Gastroenterology 1997;113:S35–42.
  • Allen A, Flemström G, Garner A, Kivilaakso E. Gastroduodenal mucosal protection. Physiol Rev 1993;73:823–57.
  • Tepperman BL, Jacobson ED. Circulatory factors in gastric mucosal defence and repair. In: Johnson LR, editor. Physiology of the gastrointestinal tract. 3rd ed. New York: Raven Press; 1994. p. 1331–52.
  • Schade C, Flemström G, Holm L. Hydrogen ion concentration in the mucus layer on top of acid-stimulated and -inhibited rat gastric mucosa. Gastroenterology 1994;107:180–8.
  • Lunde OC, Kvernebo K. Gastric blood flow in patients with gastric ulcer measured by endoscopic laser-Doppler flowmetry. Scand J Gastroenterol 1988;23:546–50.
  • Holm-Rutili L, Öbrink KJ. Rat gastric mucosal microcirculation in vivo. Am J Physiol 1985;248:G741–6.
  • Phadnis SH, Ilver D, Janzon L, Normark S, Wu T. Pathological significance and molecular characterization of the vacuolating cytotoxin gene of Helicobacter pylori. Infect Immun 1994;62: 1557–65.
  • Telford JT, Ghiara P, Dell’Orco M, Comanducci M, Burroni D, Bugnoli M, et al. Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease. J Exp Med 1994;179:1653–8.
  • Holm-Rutili L, Berglindh T. Pentagastrin and gastric mucosal blood flow. Am J Physiol 1986;250:G575–80.
  • Ahn H, Lindhagen J, Nilsson GE, Salerud EG, Jodal M, Lundgren O. Evaluation of laser-Doppler flowmetry in the assessment of intestinal blood flow in cat. Gastroenterology 1985;88:951–7.
  • Kvietys PR, Shepherd AP, Granger DN. LaserDoppler, H2 clearance, and microsphere estimates of mucosal blood flow. Am J Physiol 1985;249:G221–7.
  • Atuma C, Engstrand L, Holm L. Helicobacter pylori reduces gastric mucus secretion and mucosal blood flow in rats. Gastroenterology 1996;110 Suppl 4:A53.
  • Atuma C, Johansson M, Holm L. A study of the gastric mucus gel layers, mucus gel accumulation and the pH gradient in vivo in the rat. Eur J Physiol 1998;435 Suppl 6:R182.
  • Craig PM, Territo MC, Karnes WE, Walsh JH. Helicobacter pylori secretes a chemotactic factor for monocytes and neutrophils. Gut 1992;33:1020–3.
  • Smith SM, Holm-Rutili L, Perry MA, Grisham MB, Arfors K-E, Granger DN, et al. Role of neutrophils in hemorrhagic shock-induced gastric mucosal injury in the rat. Gastroenterology 1987;93:466–71.
  • Perez-Perez GI, Shepherd VL, Morrow JD, Blaser MJ. Activation of human THP-1 cells and rat bone marrow-derived macrophages by Helicobacter pylori lipopolysaccharide. Infect Immun 1995;63: 1183–7.
  • Nielsen H, Birkholz S, Andersen LP, Moran AP. Neutrophil activation by Helicobacter pylori lipopolysaccharides. J Infect Dis 1994;170:135–9.
  • Holm L, Jägare A. Influence of tactile stimulation of the rat gastric mucosa on blood flow and acid output. Am J Physiol 1993;265:G303–9.
  • Calam J. Helicobacter pylori, acid and gastrin. Eur J Gastroenterol Hepatol 1995;7:310–7.
  • Blaser MJ. Hypotheses on the pathogenesis and natural history of Helicobacter pylori-induced inflammation. Gastroenterology 1992;102:720–7.
  • Hunt RH. Hp and pH: implications for the eradication of Helicobacter pylori. Scand J Gastroenterol 1993;28 Suppl 196: 12–6.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.