33
Views
32
CrossRef citations to date
0
Altmetric
Research Article

Potassium Channel Modulators and Indomethacin-Induced Gastric Ulceration in Rats

Pages 962-966 | Published online: 08 Jul 2009

References

  • Djahanguiri B. The production of acute gastric ulceration by indomethacin in the rat. Scand J Gastroenterol 1969; 4: 265–7.
  • Lanza FL. Endoscopic studies and duodenal injury after the use of ibuprofen, aspirin and other nonsteroidal antiinflammatory agents. Am J Med 1984; 77: 19–24.
  • Somasundaram S, Hayllar H, Rafi S, Wrigglesworth JM, Macpherson AJS, Bjarnason I. The biochemical basis of nonsteroidal anti-inflammatory drug-induced damage to the gastro intestinal tract: A review and hypothegis. Scand J Gastroenterol 1995; 30: 289–99.
  • Anthony A, Dhillon AP, Nygard G, Hudson M, Piasecki C, Strong P, et al. Early histological features of small intestinal injury induced by indomethacin. Aliment Pharmacol Ther 1993; 7: 2940.
  • Rainsford KD. Microvascular injury during gastric mucosal damage by anti-inflammatory drugs in pigs and rats. Agents Actions 1983; 13: 5–6.
  • Anthony A, Dhillon AP, Thrasivoulou C, Pounder RE, Wakefield AJ. Pre-ulcerative villous contraction and microvascular occlusion induced by indomethacin in the rat jejunum: a detailed morphological study. Aliment Pharmacol Ther 1995; 9: 605–13.
  • Okabe S, Takeuchi K, Kunimi H, Kanno M, Kawashima M. Effects of an antiulcer drug, sucralfate (a basic aluminum salt of sulfated disaccharide) on experimental gastric lesions and gastric secretion in rats. Dig Dis Sci 1983; 28: 1034–42.
  • Mersereau WA, Hinchey EJ. Synergism between acid and gastric contractile activity in the genesis of ulceration and hemorrhage in the phenylbutazone-treated rat. Surgery 1981; 90: 516–29.
  • Ukei S, Takeuchi K, Okabe S. Gastric motility is an important factor in the pathogenesis of indomethacin-induced gastric mucosal lesions in rats. Dig Dis Sci 1988; 33: 209–16.
  • Takeuchi K, Ukei S, Okabe S. Importance of gastric motility in the pathogenesis of indomethacin-induced gastric lesions in rats. Dig Dis Sci 1986; 31: 1114–22.
  • Garcia ML, Hanner M, Knaus HG, Koch R, Schmalhofer W, Slaughter RS, et al. Pharmacology of potassium channels. Adv Pharmacol 1997; 39: 425–71.
  • Sharifi AM, Li JS, Endeman D, Schiffrin EL. Effects of enalapril and arniodipine on small artery structure and composition, and on endothelial dysfunction in spontaneously hypertensive rats. J Hypertens 1998; 16: 457–66.
  • Reece PA. Hydralazine and related compounds: chemistry, metabolism and mode of action. Med Res Rev 1981; 9: 239–51.
  • Main IHM, Whittle BJR. Investigation of the vasodilator and antisecretory role of prostagaindins in the rat gastric mucosa by use of nonsteroidal anti-inflammatory drugs. Br J Pharmacol 1975; 53: 217–24.
  • Whittle BJR. Temporal relationship between cyclooxygenase inhibition as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat. Gastroenterology 1981; 80: 94–8.
  • Ligumsky M, Golanska EM, Hansen DG, Kauffman GL. Aspirin can inhibit gastric mucosal cyclo-oxygenase without causing lesions in rat. Gastroenterology 1983; 84: 756–61.
  • Langenbach R, Morham SG, Tiano HF, Loftin CD, Ghanayeern BI, Chulada PC, et al. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell 1995; 83: 483–92.
  • Whittle BJR. Mechanisms underlying gastric mucosal damage induced by indomethacin and bile-salts and the actions on prostaglandins. Br J Pharmacol 1977; 60: 455–60.
  • Kauffman GL, Aures D, Grossman MI. Intravenous indomethacin and aspirin reduce basal gastric mucosal blood flow in dogs. Am J Physiol 1980; 234: G131–4.
  • Arakawa T, Nakamura H, Chono S, Satoh H, Fukuda T, Saeki Y, et al. Absence of effect of 16,16-dimethyl prostaglandin E2 on reduction of gastric mucosal blood flow caused by indomethacin in rats. Dig Dis Sci 1989; 34: 1369–73.
  • Ohya Y, Guth PH. Ethanol-induced gastric mucosal blood flow and vascular permeability changes in the rat. Dig Dis Sci 1988; 33: 883–8.
  • Yonei Y, Guth PH. Ethanol-induced gastric injury. Role of submucosal venoconstriction and leukotrienes. Dig Dis Sci 1991; 36: 601–8.
  • Takeuchi K, Ueshima K, Hironaka Y, Fujioka Y, Matsumoto J, Okabe S. Oxygen free radicals and lipid peroxidation in the pathogenesis of gastric mucosal lesions induced by indomethacin in rat. Relation of gastric hypermotility. Digestion 1991; 49: 175–84.
  • Mersereau WA, Hinchey EJ. Prevention of phenylbutazone ulcer in the rat by glucose: role of a glycoprivic receptor system. Am J Physiol 1982; 242: G429–32.
  • Gutierrez-Cabano CC. Protection against necrotizing agents-induced gastric lesion in rats unrelated to inhibition of gastric motility. Dig Dis Sci 1994; 39: 1864–71.
  • Doi K, Nagao T, Kawakubo K, Ibayashi S, Aoyagi K, Yano Y, et al. Calcitonin gene-related peptide affords gastric mucosal protection by activating potassium channel in Wistar rat. Gastroenterology 1998; 114: 71–6.
  • Anthony A, Bahl AK, Oakley IG, Spraggs CF, Dhillon AP, Trevethic MA, et al. The β3-adrenoceptor agonist CL316243 prevents indomethacin-induced jejunal ulceration in the rat by reversing early villous shortening. J Pathol 1996; 179: 340–6.
  • MacDonald AJ, Dekanski JB, Gotfried D, Parke DV, Sacra P. Effects of blood glucose levels on aspirin-induced gastric mucosal damage. Am J Dig Dis 1977; 22: 909–14.
  • Rainsford KD, Whitehouse MW. Biochemical gastroprotection from acute ulceration induced by aspirin and related drugs. Biochem Pharmacol 1980; 29: 1281–9.
  • Rainsford KD, Dieppe PA, Pritchard MH, Rhodes J, Leach H, Russel RI, et al. Protection from gastrointestinal side effects by azapropazone by its incorporation into a glucose-sodium acid citrate formulation. Aliment Pharmacol Ther 1991; 5: 419–33.
  • Feldman M, Colturi TJ. Effect of indomethacin on gastric acid and bicarbonate secretion in humans. Gastroenterology 1984; 87: 1339–43.
  • Soria B. Potential role of the pharmacology of K+ channels in therapeutics. In: Soria B, Cena V, editors. Ion channel pharmacology. Oxford: Oxford University Press; 1998. p. 229–45.
  • Iwata F, Koo A, Itoh M, Lam K, Leung JWC, Leung FW. Functional evidence linking potassium channels and afferent nerve-mediated mucosal protection in rat stomach. Life Sci 1997; 61: 1713–20.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.