Nutrition and Inflammatory Bowel Disease: An Update

References

• Shivananda S, Lennard-Jones J, Logan R, et al. Incidence of inflammatory bowel disease across Europe: is there a difference between north and south? Results of the European collaborative study on inflammatory bowel disease (EC-IBD). Gut 1996; 39: 690–7.
   PubMed Web of Science ®Google Scholar
• Russel MGVM, Dorant E, Volovics A, et al. High incidence of inflammatory bowel disease in The Netherlands: results of a prospective study. Dis Colon Rectum 1998; 41: 33–40.
   PubMed Web of Science ®Google Scholar
• Tysk C, Lindberg C, Jarnerot G, Floderus-Myrhed B. Ulcerative colits and Crohn’s disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking. Gut 1988; 29: 990–6.
   Google Scholar
• Nakajima A, Matsuhashi N, Kodama T, Nazaki Y, Takazoe M, Kimura A. HLA linked susceptibility and resistance gene in Crohn’s disease. Gastroenterology 1995; 109: 1462–7.
   PubMed Web of Science ®Google Scholar
• Russel MGVM, Engels LG, Muris JW, et al. ‘Modern life’ in the epidemiology of inflammatory bowel disease: a case-control study with special emphasis on nutritional factors. Eur J Gastroenterol Hepatol 1998; 10: 243–9.
   PubMedGoogle Scholar
• Tragnone A, Valpiani D, Miglio F, et al. Dietary habits as risk factors for inflammatory bowel disease. Eur J Gastroenterol Hepatol 1995; 7: 47–51.
   PubMed Web of Science ®Google Scholar
• Gilat T, Langman MJS, Rozen P. Environmental factors in inflammatory bowel disease. Front Gastrointest Res 1986; 11: 158–76.
   Google Scholar
• Martini GA, Brandes JW. Increased consumption of refined carbohydrates in patients with Crohn’s disease. Klinische Wochenschrift 1976; 54: 367–71.
   PubMedGoogle Scholar
• Millar B, Fervers F, Rohbeck R, Strohmeyer G. Sugar consumption in patients with Crohn’s disease. Verh Dtsch Ges Inn Med 1976; 82: 922–4 (in German).
   PubMedGoogle Scholar
• Graham WB, Torrance B, Taylor TV. Breakfast and Crohn’s disease [letter]. Br Med J 1978; 2: 768.
   PubMedGoogle Scholar
• Mayberry JF, Rhodes J, Newcombe RG. Breakfast and dietary aspects of Crohn’s disease. Br Med J 1978; 2: 1401.
   Google Scholar
• Mayberry JF, Rhodes J, Newcombe RG. Increased sugar consumption in Crohn’s disease. Digestion 1980; 20: 323–6.
   Google Scholar
• Mayberry JF, Rhodes J, Allan R, et al. Diet in Crohn’s disease. Two studies of current and previous habits in newly diagnosed patients. Dig Dis Sci 1981; 26: 444–8.
   Google Scholar
• Rawcliffe PM, Truelove SC. Breakfast and Crohn’s disease. Br Med J 1978; 2: 539–40.
   PubMedGoogle Scholar
• Kasper H, Sommer H. Dietary fibre and nutrient intake in Crohn’s disease. Am J Clin Nutr 1979; 32: 1898–901.
   PubMed Web of Science ®Google Scholar
• Thornton JR, Emmet PM, Heaton KW. Diet and Crohn’s disease: characteristics of the pre-illness diet. Br Med J 1979; 2: 762–4.
   Google Scholar
• Silkoff K, Hallak A, Yegena L, et al. Consumption of refined carbohydrates by patients with Crohn’s disease in Tel-Aviv-Yafo. Postgrad Med J 1980; 56: 842–6.
   PubMed Web of Science ®Google Scholar
• Jarnerot G, Jarnmark I, Nilsson K. Consumption of refined sugar by patients with Crohn’s disease, ulcerative colitis or irritable bowel syndrome. Scand J Gastroenterol 1983; 18: 999–1002.
   Google Scholar
• Penny WJ, Mayberry JF, Aggett PJ, Gilbert JO, Newcombe RG, Rhodes J. Relationship between trace elements, sugar consumption, and taste in Crohn’s disease. Gut 1983; 24: 288–92.
   PubMed Web of Science ®Google Scholar
• Brauer PM, Gee MI, Grace M, Thomson ABR. Diet of women with Crohn’s and other gastrointestinal diseases. J Am Diet Assoc 1983; 82: 659–64.
   PubMedGoogle Scholar
• Porro GB, Panza E. Smoking, sugar and inflammatory bowel disease. Br Med J 1985; 291: 971–2.
   Google Scholar
• Panza E, Franceschi S, La Vecchia C, et al. Dietary factors in the aetiology of inflammatory bowel disease. Ital J Gastroenterol 1987; 19: 205–9.
   Google Scholar
• Katschinski B, Logan RFA, Edmond M, Langman MJS. Smoking and sugar intake are separate but interactive risk factors in Crohn’s disease. Gut 1988; 29: 1202–6.
   PubMed Web of Science ®Google Scholar
• Matsui T, Iida M, Fujishima M, Imai K, Yao T. Increased sugar consumption in Japanese patients with Crohn’s disease. Gastroenterologia Japonica 1990; 25: 271.
   Google Scholar
• Persson PG, Ahlbom A, Hellers G. Diet and inflammatory bowel disease: a case control study. Epidemiology 1992; 3: 47–52.
   Google Scholar
• Reif S, Klein I, Lubin F, Farbstein M, Hallak A, Gilat T. Preillness dietary factors in inflammatory bowel disease. Gut 1997; 40: 754–60.
   PubMedGoogle Scholar
• Thornton JR, Emmet PM, Heaton KW. Diet and ulcerative colitis. Br Med J 1980; 2: 293–4.
   Google Scholar
• Thornton JR, Emmet PM, Heaton KW. Smoking, sugar and inflammatory bowel disease. Br Med J 1985; 290: 1786–7.
   Google Scholar
• Riordan AM, Ruxton CHS, Hunter JO. A review of associations between Crohn’s disease and consumption of sugars. Eur J Clin Nutr 1998; 52: 229–38.
   Google Scholar
• Sonnenberg A. Geographic and temporal variations of sugar and margarine consumption in relation to Crohn’s disease. Dig 1988; 41: 161–71.
   PubMedGoogle Scholar
• Ritchie JK, Wadsworth J, Lennard-Jones JE, Rogers E. Controlled multicentre therapeutic trial of an unrefined carbohydrate, fibre-rich diet in Crohn’s disease. Br Med J Clin Res 1987; 295: 517–20.
   Google Scholar
• Alun Jones V, Dickinson RJ, Workman E, Wilson AJ, Freeman AH, Hunter JO. Crohn’s disease: maintenance of remission by diet. Lancet 1985; ii: 177–80.
   Google Scholar
• Lorenz-Meyer H, Nicolay C, Schulz B, et al. Omega-3 fatty acids and low carbohydrate diet for maintenance of remission in Crohn’s disease: a randomized controlled multicenter trial. Scand J Gastroenterol 1996; 31: 778–85.
   Google Scholar
• McKeown GE, Sing Yeung KA, Bright-See E. Assessment of past diet in epidemiologic studies. Am J Epidemiol 1986; 124: 94–103.
   PubMedGoogle Scholar
• Gilat T, Hacohen D, Lilos P, Langman MJS. Childhood factors in ulcerative colitis and Crohn’s disease. An international cooperative study. Scand J Gastroenterol 1987; 22: 1009–24.
   PubMed Web of Science ®Google Scholar
• Guthy E. Morbus Crohn und nahrungsfette. Hypothese zur aetiologie der enteritis regionalis. Dtsch Med Wschr 1982; 107: 71–3.
   PubMedGoogle Scholar
• Epidemiology group of the Research Committee of Inflammatory Bowel Disease in Japan.. Dietary and other risk factors of ulcerative colitis: a case control study in Japan. J Clin Gastroenterol 1994; 19: 166–71.
   PubMedGoogle Scholar
• Chuah SY, Jayanthi V, Lee CN, McDonald B, Probert CSJ, Mayberry JF. Dietary fats and inflammatory bowel disease in Asians. Ital J Gastroenterol 1992; 24: 386–8.
   PubMedGoogle Scholar
• Guthy E. Atiologie des Morbus Crohn. Was spricht fur Fette als mogliche Ursache. Dtsch Med Wschr 1983; 108: 1719–20.
   PubMedGoogle Scholar
• Shoda R, Matsueda K, Yamato S, Umeda N. Epidemiologic analysis of Crohn’s disease in Japan: increased dietary intake of n-6 polyunsaturated fatty acids and animal protein relates to the increased incidence of Crohn’s disease in Japan. Am J Clin Nutr 1996; 63: 741–5.
   PubMed Web of Science ®Google Scholar
• Crohn BB, Ginzberg L, Oppenheimer GD. Regional ileitis, a pathologic and clinical entity. J Am Med Assoc 1932; 99: 1323.
   Google Scholar
• Harries AD, Jones LA, Heatley RV, Rhodes J. Malnutrition in inflammatory bowel disease: an anthropometric study. Hum Nutr Clin Nutr 1982; 36C: 307–13.
   Google Scholar
• Lanfranchi GA, Brignola C, Campieri M, et al. Assessment of nutritional status in Crohn’s disease in remission or low activity. Hepatogastroenterol 1984; 31: 129–32.
   PubMedGoogle Scholar
• Gee MI, Grace MGA, Wensel RH, Sherbaniuk RW, Thompson ABR. Nutritional status of gastroenterology outpatients: comparison of inflammatory bowel disease with functional disorders. J Am Diet Assoc 1985; 85: 1591–9.
   Google Scholar
• Zurita VF, Rawls DE, Dyck WP. Nutritional support in inflammatory bowel disease. Dig Dis 1995; 503: 92–107.
   Google Scholar
• Fleming CR. Nutrition considerations in patients with Crohn’s disease. Semin Colon Rectal Surg 1994; 5: 167–73.
   Google Scholar
• Weinsier RL, Heimburger DC. Distinguishing malnutrition from disease: the search goes on. Am J Clin Nutr 1997; 66: 1063–4.
   PubMed Web of Science ®Google Scholar
• Jeejeebhoy KN, Detsky AS, Baker JP. Assessment of nutritional status. JPEN J Parenter Enteral Nutr 1990; 14 Suppl: 193–6.
   Google Scholar
• Charney P. Nutrition assessment in the 1990s: where are we now? Nutr Clin Pract 1995; 10: 131–9.
   PubMedGoogle Scholar
• Silk DBA, Payne-James J. Inflammatory bowel disease: nutritional implications and treatment. Proc Nutr Soc 1989; 48: 355–61.
   PubMedGoogle Scholar
• Royall D, Greenberg GR, Allard JP, Baker JP, Jeejeebhoy KN. Total enteral nutrition support improves body composition of patients with active Crohn’s disease. JPEN J Parenter Enteral Nutr 1995; 19: 95–9.
   PubMed Web of Science ®Google Scholar
• Stokes MA, Hill GL. Total energy expenditure in patients with Crohn’s disease: measurement by the combined body scan technique. JPEN J Parenter Enteral Nutr 1993; 17: 3–7.
   PubMed Web of Science ®Google Scholar
• Jacobson S, Carlmark B. Total body potassium, fat and water using total parenteral nutrition in Crohn’s disease. Clin Nutr 1990; 9: 272–80.
   PubMedGoogle Scholar
• Stokes MA. Crohn’s disease and nutrition. Br J Surg 1992; 79: 391–4.
   PubMed Web of Science ®Google Scholar
• Shenkin A. Impact of disease on markers of macronutrient status. Proc Nutr Soc 1997; 56: 433–41.
   PubMedGoogle Scholar
• Main ANH, Mills PR, Russell RI, et al. Vitamin A deficiency in Crohn’s disease. Gut 1983; 24: 1169–75.
   PubMedGoogle Scholar
• Schoelmerich J, Bechner MS, Hoppe-Seyler P, et al. Zinc and vitamin A deficiency in patients with Crohn’s disease is correlated with activity but not with localization or extent of the disease. Hepatogastroenterol 1985; 32: 34–8.
   Google Scholar
• Janczewska I, Bartnik W, Butruk E, Tomecki R, Kazik E, Ostrowski J. Metabolism of vitamin A in inflammatory bowel disease. Hepatogastroenterol 1991; 38: 391–5.
   PubMed Web of Science ®Google Scholar
• Fernandez-Banares F, Abad-Lacruz A, Xiol X, et al. Vitamin status in patients with inflammatory bowel disease. Am J Gastroenterol 1989; 84: 744–8.
   PubMed Web of Science ®Google Scholar
• Kuroki F, Iida M, Tominaga M, et al. Multiple vitamin status in Crohn’s disease. Correlation with disease activity. Dig Dis Sci 1993; 38: 1614–8.
   PubMed Web of Science ®Google Scholar
• Thurnham DI. Impact of disease on markers of micronutrient status. Proc Nutr Soc 1997; 56: 421–31.
   PubMed Web of Science ®Google Scholar
• Imes S, Pinchbeck B, Dinwoodie A, Walker K, Thomson ABR. Vitamin A status in 137 patients with Crohn’s disease. Dig 1987; 37: 166–70.
   Google Scholar
• Geerling BJ, Badart-Smook A, Stockbrügger RW, Brummer R-JM. Comprehensive nutritional status in patients with longstanding Crohn’s disease in remission. Am J Clin Nutr 1998; 67: 919–26.
   PubMed Web of Science ®Google Scholar
• Cravo M, Gloria L, Salazar de Sousa L, et al. Folate status, DNA methylation and colon cancer risk in inflammatory bowel disease. Clin Nutr 1995; 14: 50–3.
   Google Scholar
• Steger GG, Mader RM, Vogelsang H, Schofl R, Lochs H, Ferenci P. Folate absorption in Crohn’s disease. Dig 1994; 55: 234–8.
   PubMed Web of Science ®Google Scholar
• Herbert V, Das KC. The role of vitamin B12 and folic acid metabolism: folic acid clearance studies. Vitam Horm 1976; 34: 1–30.
   PubMed Web of Science ®Google Scholar
• Lashner BA. Red blood cell folate is associated with the development of dysplasia and cancer in ulcerative colitis. J Cancer Res Clin Oncol 1993; 119: 549–54.
   PubMedGoogle Scholar
• Behrend C, Jeppesen PB, Mortensen PB. Vitamin B12 absorption after ileorectal anastomosis for Crohn’s disease: effect of ileal resection and time span after surgery. Eur J Gastroenterol Hepatol 1995; 7: 397–400.
   Google Scholar
• Buffinton GD, Doe WF. Altered ascorbic acid status in the mucosa from inflammatory bowel disease patients. Free Radic Res 1995; 22: 131–43.
   PubMed Web of Science ®Google Scholar
• Imes S, Dinwoodie A, Walker K, Pinchbeck B, Thompson AB. Vitamin C status in 137 outpatients with Crohn’s disease. Effect of diet counselling. J Clin Gastroenterol 1986; 8: 443–6.
   Google Scholar
• Leichtmann GA, Bengoa JM, Bolt MJG, Sitrin MD. Intestinal absorption of cholecalciferol and 25-hydroxycholecalciferol in patients with both Crohn’s disease and intestinal resection. Am J Clin Nutr 1991; 54: 548–52.
   PubMed Web of Science ®Google Scholar
• van Nunen AB, Schoon EJ, Russel MG, Stockbriigger RW, Brummer R-JM. Vitamin D deficiency and osteopenia in Crohn’s disease [abstract]. Eur J Gastroenterol Hepatol 1997; 9: A5.
   Google Scholar
• Harries AD, Brown R, Heatley RV, Williams LA, Woodhead S, Rhodes J Gut 1985; 26: 1197–203.
   Google Scholar
• Schoon EJ, van Nunen AB, Heidendal G, et al. Low body fat and risk for osteoporosis in Crohn’s disease. Gut 1996; 39 Suppl 3: A958.
   Google Scholar
• Abitbol V, Roux C, Chaussade S, et al. Metabolic bone assessment in patients with inflammatory bowel disease. Gastroenterology 1995; 108: 417–22.
   PubMed Web of Science ®Google Scholar
• Silvennoinen J. Relationships between vitamin D, parathyroid hormone and bone mineral density in inflammatory bowel disease. J Intern Med 1996; 239: 131–7.
   PubMed Web of Science ®Google Scholar
• Schoon EJ, Geerling BJ, Schurgers L, Vermeer C, Stock-brügger RW, Brummer R-JM. Bone formation is suppressed and bone resorption is normal in long-standing quiescent Crohn’s disease [abstract]. Gastroenterology 1998; 114: A1080.
   Google Scholar
• Steinhart AH, Greenberg GR. Nutrition in inflammatory bowel disease. Curr Opin Gastroenterol 1997; 13: 140–5.
   Google Scholar
• Kuroki F, Iida M, Tominaga M, Matsumoto T, Kanamoto K, Fujishima M. Is vitamin E depleted in Crohn’s disease at initial diagnosis? Dig Dis 1994; 12: 248–54.
   PubMedGoogle Scholar
• Loeschke K, Konig A, Haeberlin ST. Low blood selenium concentrations in Crohn’s disease. Ann Intern Med 1987; 106: 908.
   Google Scholar
• Hinks LJ, Inwards KD, Lloyd B, Clayton B. Reduced concentrations of selenium in mild Crohn’s disease. J Clin Pathol 1988; 41: 198–201.
   PubMed Web of Science ®Google Scholar
• Ringstad J, Kildebo S, Thomassen Y. Serum selenium, copper, and zinc concentrations in Crohn’s disease and ulcerative colitis. Scand J Gastroenterol 1993; 28: 605–8.
   Google Scholar
• Rannem T, Ladefoged K, Hylander E, Hegnhøj J, Jarnum S. Selenium status in patients with Crohn’s disease. Am J Clin Nutr 1992; 56: 933–7.
   PubMed Web of Science ®Google Scholar
• Fernandez-Banares F, Mingorance MD, Esteve M, et al. Serum zinc, copper, and selenium levels in inflammatory bowel disease: effect of total enteral nutrition on trace element status. Am J Gastroenterol 1990; 85: 1584–9.
   Google Scholar
• Hoffenberg EJ, Deutsch J, Smith S, Sokol RJ. Circulating antioxidant concentrations in children with inflammatory bowel disease. Am J Clin Nutr 1997; 65: 1482–8.
   PubMed Web of Science ®Google Scholar
• Thomas AG, Miller V, Shenkin A, Fell GS, Taylor F. Selenium and gluthatione peroxidase status in pediatric health and gastrointestinal disease. J Pediatr Gastroenterol Nutr 1994; 19: 213–9.
   PubMedGoogle Scholar
• Fernandez-Banares F, Dolz C, Mingorance MD, et al. Low serum selenium concentrations in healthy population resident in Catalunya: a preliminary report. Eur J Clin Nutr 1990; 44: 225–9.
   Google Scholar
• Andersson H, Bosaeus I, Brummer R-J, et al. Nutritional and metabolic consequences of extensive bowel resection. Dig Dis 1986; 4: 193–202.
   Google Scholar
• Sjogren A, Floren CH, Nilsson A. Evaluation of magnesium status in Crohn’s disease as assessed by intracellular analysis and intravenous magnesium infusion. Scand J Gastroenterol 1981; 23: 555–61.
   Google Scholar
• Hessov I, Hasselblad C, Fasth S, Hulten L. Magnesium deficiency after ileal resection for Crohn’s disease. Scand J Gastroenterol 1983; 18: 643–9.
   PubMed Web of Science ®Google Scholar
• Galland L. Magnesium and inflammatory bowel disease. Magnesium 1988; 7: 78–83.
   PubMedGoogle Scholar
• Kelly DG, Fleming CR. Nutritional considerations in inflammatory bowel diseases. Gastroenterol Clin North Am 1995; 24: 597–611.
   PubMedGoogle Scholar
• Hendricks KM, Walker WA. Zinc deficiency in inflammatory bowel disease. Nutr Rev 1988; 46: 401–8.
   PubMed Web of Science ®Google Scholar
• Naber THJ, van den Hamer CJA, Baadenhuysen H, Jansen JBMJ. Zinc deficiency in Crohn’s disease. Am J Clin Nutr 1997; 66: 1232–9.
   PubMed Web of Science ®Google Scholar
• Valberg LS, Flanagan PR, Kertesz A, Dondy DC. Zinc absorption in inflammatory bowel disease. Dig Dis Sic 1986; 31: 724–31.
   PubMed Web of Science ®Google Scholar
• Sandstrom B, Davidsson L, Bosaeus I, Eriksson R, Alpsten M. Selenium status and absorption of zinc (⁶⁵Zn), selenium (⁷⁵Se) and manganese (⁵⁴Mn) in patients with short bowel syndrome. Eur J Clin Nutr 1990; 44: 697–703.
   Google Scholar
• Fleming CR, Huizenga KA, McCall JT, Gildea J, Dennis R. Zinc nutrition in Crohn’s disease. Dig Dis Sci 1981; 26: 865–70.
   PubMedGoogle Scholar
• Mulder TPJ, Verspaget HW, Janssens AR, de Bruin PAF, Peha AS, Lamers CBHW. Decrease in two intestinal copper/zinc containing proteins with antioxidant function in inflammatory bowel disease. Gut 1991; 32: 1146–50.
   Google Scholar
• Goode HF. Inflammatory bowel disease, free radicals and zinc. J Gastroenterol Hepatol 1994; 9: 519–20.
   PubMedGoogle Scholar
• Naber THJ, Baadenhuysen H, Jansen JBMJ, van den Hamer CJA, van den Broek W. Serum alkaline phosphatase activity during zinc deficiency and long-term inflammatory stress. Clin Chim Acta 1996; 249: 109–27.
   Google Scholar
• Ainley CC, Cason J, Carlsson LK, Slavin BM, Thompson RPH. Zinc status in inflammatory bowel disease. Clin Sci 1988; 75: 277–83.
   Google Scholar
• Ainley CC, Cason J, Slavin BM, Wolstencroft RA, Thompson RPH. The influence of zinc status and malnutrition on immunological function in Crohn’s disease. Gastroenterology 1991; 100: 1616–25.
   Google Scholar
• Naber THJ, Heymer F, van den Hamer CJA, Broek WJM, Jansen JBMJ. The in vitro uptake of zinc by blood cells in rats with long term inflammatory stress. Clin Nutr 1994; 13: 247–55.
   Google Scholar
• Solomons NW. On the assessment of zinc and copper nutrition in man. Am J Clin Nutr 1979; 32: 856–71.
   PubMed Web of Science ®Google Scholar
• Harries AD, Danis VA, Heatley RV. Influence of nutritional status on immune functions in patients with Crohn’s disease. Gut 1984; 25: 465–72.
   Google Scholar
• Grimble RF. Nutritional antioxidants and the modulation of inflammation: theory and practice. New Horiz 1994; 32: 175–85.
   Google Scholar
• Wan JMF, Haw MP, Blackburn GL. Nutrition, immune function, and inflammation: an overview. Proc Nutr Soc 1989; 48: 315–35.
   Google Scholar
• Verspaget HW, Mulder TPJ, van der Sluys Veer A, Peña AS, Lamers CBHW. Reactive oxygen metabolites and colitis: a disturbed balance between damage and protection. Scand J Gastroenterol 1991; 26 Suppl 188: 44–51.
   Google Scholar
• Conner EM, Grisham MB. Inflammation, free radicals, and antioxidants. Nutrition 1996; 12: 274–7.
   PubMed Web of Science ®Google Scholar
• Öjerskog B, Andersson H, Bosaeus I, Brevinge H, Nilsson LO. Total body water and total body potassium in ileostomy patients before and after conversion to the continent ileostomy. Gut 1988; 29: 1198–201.
   Google Scholar
• Christie PM, Graham MB, Hill GL. Return to normal body composition after ileoanal J-pouch anastomosis for ulcerative colitis. Dis Colon Rectum 1990; 33: 584–6.
   Google Scholar
• Christie PM, Knight GS, Hill GL. Metabolism of body water and electrolytes after surgery for ulcerative colitis: conventional ileostomy versus J pouch. Br J Surg 1990; 77: 149–51.
   Google Scholar
• Royall D, Greenberg GR, Allard JP, Baker JP, Harrison JE, Jeejeebhoy KN. Critical assessment of body composition measurements in malnourished subjects with Crohn’s disease: the role of bioelectric impedance analysis. Am J Clin Nutr 1994; 59: 325–30.
   PubMed Web of Science ®Google Scholar
• Azcue M, Rashid M, Griffiths A, Pencharz PB. Energy expenditure and body composition in children with Crohn’s disease: effect of enteral nutrition and treatment with prednisolone. Gut 1997; 41: 203–8.
   PubMed Web of Science ®Google Scholar
• Geerling BJ, van Marken Lichtenbelt W, Stockbrügger RW, Brummer R-JM. Body water compartments of patients with inflammatory bowel disease compared to controls [abstract]. Clin Nutr 1996; 15: O70.
   Google Scholar
• Streat SJ, Beddoe AH, Hill GL. Measurement of body fat and hydration of the fat-free body in health and disease. Metabolism 1985; 34: 509–18.
   Google Scholar
• Chrousos GP. The hyothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med 1995; 332: 1351–62.
   PubMed Web of Science ®Google Scholar
• Lopes J, Russell DM, Whitwell J, Jeejeebhoy KN. Skeletal muscle function in malnutrition. Am J Clin Nutr 1982; 36: 602–10.
   PubMed Web of Science ®Google Scholar
• Nishio ML, Jeejeebhoy KN. Effect of malnutrition on aerobic and anaerobic performance of fast- and slow-twitch muscles of rats. JPEN J Parenter Enteral Nutr 1992; 16: 219–25.
   PubMedGoogle Scholar
• Brevinge H, Berglund B, Bosaeus I, Tolli J, Nordgren S, Lundholm K. Exercise capacity in patients undergoing proctocolectomy and small bowel resection for Crohn’s disease. Br J Surg 1995; 82: 1040–5.
   PubMedGoogle Scholar
• Kalfarentzos F, Spiliotis J, Velimezis G, Dougenis D, Androulakis J. Comparison of forearm muscle dynamometry with nutritional prognostic index, as a preoperative indicator in cancer patients. JPEN J Parenter Enteral Nutr 1989; 13: 34–6.
   Google Scholar
• Berkelhammer CH, Leiter LA, Jeejeebhoy KN, et al. Skeletal muscle function in chronic renal failure: an index of nutritional status. Am J Clin Nutr 1985; 42: 845–54.
   PubMedGoogle Scholar
• Gleeson NP, Mercer TH. The utility of isokinetic dynamometry in the assessment of human muscle function. Sports Med 1996; 21: 18–34.
   PubMed Web of Science ®Google Scholar
• Teahon K, Bjarnason I, Pearson M, Levi AJ. Ten years experience with elemental diet in the management of Crohn’s disease. Gut 1190; 31: 1133–7.
   Google Scholar
• O’Morain CA, O’Sullivan MA. Nutritional support in Crohn’s disease: current status and future directions. J Gastroenterol 1995; 30 Suppl VIII: 102–7.
   Google Scholar
• King TS, Woolner JT, Hunter JO. Review article: the dietary management of Crohn’s disease. Aliment Pharmacol 1997; 11: 17–31.
   Google Scholar
• Stenson WF, Alpers DH. Nutritional therapy in inflammatory bowel disease: a historical overview. Curr Opin Gastroenterol 1997; 13: 135–9.
   Google Scholar
• O’Sullivan MA, O’Morain CA. Nutritional therapy in Crohn’s disease. Inflammatory Bowel Disease 1998; 4: 45–53.
   PubMedGoogle Scholar
• Griffiths AM, Ohlsson A, Sherman PM, Sutherland LR. Metaanalysis of enteral nutrition as primary treatment of active Crohn’s disease. Gastroenterology 1995; 108: 1056–67.
   PubMed Web of Science ®Google Scholar
• Fernandez-Banares F, Cabre E, Esteve-Comas M, Gassull MA. How effective is enteral nutrition in inducing clinical remission in active Crohn’s disease? A meta-analysis of the randomized clinical trials. JPEN J Parenter Enteral Nutr 1995; 19: 356–64.
   Google Scholar
• Messori A, Trallori G, D’albasio G, Milla M, Vannozzi G, Pacini F. Defined-formula diets versus steroids in the treatment of active Crohn’s disease: a meta-analysis. Scand J Gastroenterol 1996; 31: 267–72.
   Google Scholar
• O’Morain C, Tobin A, Suzuki Y, McColl T, Collins R. Fish oil in the treatment of ulcerative colitis. Can J Gastroenterol 1990; 4: 420–3.
   Google Scholar
• Sanderson IR. Diet and gut inflammation. Curr Opin Gastroenterol 1997; 13: 518–24.
   Google Scholar
• Lorenz R, Weber PC, Szimnau P, Heldwein W, Strasser T, Loeschke K. Supplementation with n-3 fatty acids from fish oil in chronic inflammatory bowel disease—A randomized, placebo-controlled, double-blind cross-over trial. J Int Med 1989; 225 Suppl 1: 225–32.
   Google Scholar
• McCall TB, O’Leary D, Bloomfield J, O’Morain CA. Therapeutic potential of fish oil in the treatment of ulcerative colitis. Aliment Pharmacol Ther 1989; 3: 415–24.
   PubMed Web of Science ®Google Scholar
• Aslan A, Triadafilopoulos G. Fish oil fatty acid supplementation in active ulcerative colitis: a double-blind, placebocontrolled, crossover study. Am J Gastroenterol 1992; 87: 432–7.
   PubMed Web of Science ®Google Scholar
• Stenson WF, Cort DC, Rodgers J, et al. Dietary supplementa-tion with fish oil in ulcerative colitis. Ann Int Med 1992;116:609–14.
   PubMed Web of Science ®Google Scholar
• Hawthorne AB, Daneshmend TK, Hawkey CJ, et al. Treatment of ulcerative colitis with fish oil supplementation: a prospective 12-month randomised controlled trial. Gut 1992;33:922–8.
   PubMed Web of Science ®Google Scholar
• Girelli D, Olivieri O, Stanzial AM, et al. Factors affecting the thiobarbituric acid test as index of red blood cell susceptibility to lipid peroxidation: a multivariate analysis. Clin Chim Acta 1994;227:45–57.
   PubMed Web of Science ®Google Scholar
• Belluzi A, Brignola C, Campieri M, Pera A, Boschi S, Migliolo M. Effect of an enteric-coated fish-oil preparation on relapses in Crohn’s disease. N Eng J Med 1996;334:1557–60.
   PubMedGoogle Scholar
• Hughes DA, Southon S, Pinder AC. n-3 polyunsaturated fatty acids modulate the expression of functionally associated molecules on human monocytes in vitro. J Nutr 1996; 126:603–10.
   Google Scholar
• Roediger WEW. The starved colon-diminished mucosal nutrition, diminished absorption, and colitis. Dis Colon Rectum 1990;33:858–62.
   PubMed Web of Science ®Google Scholar
• Vernia P, Gnaedinger A, Hauck W, Breuer RI. Organic anions and the diarrhea of inflammatory bowel disease. Dig Dis Sci 1988;33:1353–8.
   PubMed Web of Science ®Google Scholar
• Cummings JH. Short chain fatty acids in the treatment of distal colitis. Eur J Gastroenterol Hepatol 1997;9:149–53.
   PubMed Web of Science ®Google Scholar
• Scheppach W, for the German-Austrian SCFA Study Group. Treatment of distal ulcerative colitis with short-chain fatty acids enemas: a placebo-controlled trial. Dig Dis Sci 1996; 41: 2254–9.
   Google Scholar
• Steinhart AH, Hiruki T, Brezinski A, Baker JP. Treatment of left-sided ulcerative colitis with butyrate enemas: a controlled trial. Aliment Pharmacol Ther 1996; 10: 729–36.
   PubMed Web of Science ®Google Scholar
• Breuer RI, Soergel KH, Lashner BA, et al. Short chain fatty acid rectal irrigation for left sided ulcerative colitis: a randomized, placebo controlled trial. Gut 1997; 40: 485–91.
   PubMed Web of Science ®Google Scholar
• Roediger WEW. The colonic epithelium in ulcerative colitis: an energy-deficient disease? Lancet 1980; 2: 712–5.
   PubMed Web of Science ®Google Scholar
• Scheppach W. Short-chain fatty acids improve epithelia in ulcerative colitis? Speculation on mechanisms. In: Binder HJ, Cummings J, Soergel KH, editors. Short chain fatty acids. Dordrecht: Kluwer Academic Publishers, 1993. p. 206–13.
   Google Scholar
• Florin THJ, Gibson JR, Neale G, Cummings JH. A role for sulfate reducing bacteria in ulcerative colitis [abstract]. Gastroenterology 1990; 98: A170.
   Google Scholar
• LeLeko NS, Walsh MJ. The role ofglutamine, short-chain fatty acids, and nucleotides in intestinal adaptation to gastrointestinal disease. Ped Clin North Am 1996; 43: 451–69.
   PubMedGoogle Scholar
• van der Hulst RRWJ, van Kreel BK, von Meyenfeldt MF, et al. The role of parenteral glutamine administration in preserving gut integrity. Lancet 1993; 334: 1363–5.
   Google Scholar
• Wischmeyer P, Pemberton JH, Phillips SF. Chronic pouchitis after ileal pouch-anal anastomosis: responses to butyrate and glutamine suppositories in a pilot study. Mayo Clin Proc 1993; 68: 978–81.
   Google Scholar