18
Views
5
CrossRef citations to date
0
Altmetric
Original Article

Divergent expression changes of telomerase and E6/E7 mRNA, following integration of human papillomavirus type 33 in cultured epithelial cells

, , &
Pages 302-304 | Received 04 Dec 2003, Accepted 14 Jan 2004, Published online: 08 Jul 2009

References

  • Greider CW, Blackburn EH. Identification of a specific telomere terminal transferase activity in tetrahymena extracts. Cell 1985; 43: 405–41320.
  • Morin GB. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell 1989; 59: 521–9.
  • Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, et al. Specific association of human telomerase activity with immortal cells and cancer. Science 1994; 266: 2011–5.
  • Shay JW, Bacchetti S. A survey of telomerase activity in human cancer. Eur J Cancer 1997; 33: 787–91.
  • Wright WE, Piatyszek MA, Rainey WE, Byrd W, Shay JW. Telomerase activity in human germline and embryonic tissues and cells. Dev Genet 1996; 18: 173–9.
  • McKenzie KE, Umbricht CB, Sukumar S. Applications of telomerase research in the fight against cancer. Mol Med Today 1999; 5: 114–22.
  • Romanczuk H, Howley PM. Disruption of either the E1 or the E2 regulatory gene of human papillomavirus type 16 increases viral immortalization capacity. Proc Natl Acad Sci USA 1992; 89: 3159–63.
  • Jeon S, Lambert PF. Integration of human papillomavirus type 16 DNA into the human genome leads to increased stability of E6 and E7 mRNAs: implications for cervical carcinogenesis. Proc Natl Acad Sci USA 1995; 92: 1654–8.
  • Klingelhutz AJ, Foster SA, McDougall JK. Telomerase activation by the E6 gene product of human papillomavirus type 16. Nature 1996; 380: 79–82.
  • Oh ST, Kyo S, Laimins LA. Telomerase activation by human papillomavirus type 16 E6 protein: induction of human telomerase reverse transcriptase expression through Myc and GC-rich Sp1 binding sites. J Virol 2001; 75: 5559–66.
  • Veldman T, Horikawa I, Barrett JC, Schlegel R. Transcriptional activation of the telomerase hTERT gene by human papillomavirus type 16 E6 oncoprotein. J Virol 2001; 75: 4467–72.
  • Gewin L, Galloway DA. E box-dependent activation of telomerase by human papillomavirus type 16 E6 does not require induction of c-myc. J Virol 2001; 75: 7198–201.
  • Lee D, Kim HZ, Jeong KW, Shim YS, Horikawa I, Barrett JC, Choe J. Human papillomavirus E2 down-regulates the human telomerase reverse transcriptase promoter. J Biol Chem 2002; 277: 27748 56.
  • Hietanen S, Auvinen E, Grenman S, Lakkala T, Sajantila A, Klemi P, Maenpaa J. Isolation of 2 keratinocyte cell lines derived from HPV-positive dysplastic vaginal lesions. Int J Cancer 1992; 52: 391–8.
  • Peitsaro P, Hietanen S, Johansson B, Lakkala T, Syrjanen S. Single copy heterozygote integration of HPV 33 in chromosomal band 5p14 is found in an epithelial cell clone with selective growth advantage. Carcinogenesis 2002; 23: 1057–64.
  • Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951; 39: 265 75.
  • de Kok JB, Zendman AJ, van de Locht LT, Ruers TJ, van Muijen GN, Mensink EJ, Swinkels DW. Real-time hTERT quantification: a promising telomerase-associated tumour marker. Lab Invest 1999; 79: 911 2.
  • Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, Lingner J, Harley CB, et al. Telomerase catalytic subunit homologues from fission yeast and human. Science 1997; 277: 955 9.
  • Snijders PJ, van den Brule AJ, Schrijnemakers HF, Raaphorst PM, Meijer CJ, Walboomers JM. Human papillomavirus type 33 in a tonsillar carcinoma generates its putative E7 mRNA via two E6* transcript species which are terminated at different early region poly(A) sites. J Virol 1992; 66: 3172–8.
  • Baege AC, Berger A, Schlegel R, Veldman T, Schlegel R. Cervical epithelial cells transduced with the papillomavirus E6 E7 oncogenes maintain stable levels of oncoprotein expression but exhibit progressive, major increases in hTERT gene expression and telomerase activity. Am J Pathol 2002; 160: 1251–7.
  • Kiyono T, Foster SA, Koop JI, McDougall JK, Galloway DA, Klingelhutz AJ. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 1998; 396: 84–8.
  • Sprague D, Phillips S, Mitchell C, Berger K, Lace M, Turek L, Klingelhutz A. Telomerase activation in cervical keratinocytes containing stably replicating human papillomavirus type 16 episomes. Virology 2002; 301: 247–54.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.