42
Views
19
CrossRef citations to date
0
Altmetric
Research Article

Wegener's Granulomatosis: Inflammatory Cells and Markers of Repair and Fibrosis in Renal Biopsies - A Clinicopathological Study

Pages 401-410 | Published online: 09 Jul 2009

References

  • Hoffman GS, Kerr GS, Leavitt RY, Hallahan CW, Lebovics RS, Travis WD, et al. Wegener granuloma-tosis: an analysis of 158 patients. Ann Intern Med 1992; 116: 488–98.
  • Westman KW, Bygren PG, Olsson H, Ranstam J, Wieslander J. Relapse rate, renal survival, and cancer morbidity in patients with Wegener's granulomatosis or microscopic polyangiitis with renal involvement. J Am Soc Nephrol 1998; 9: 842–52.
  • Aasarod K, Iversen BM, Hammerstrom J, Bostad L, Vatten L, Jorstad S. Wegener's granulomatosis: clinical course in 108 patients with renal involvement. Nephrol Dial Transplant 2000; 15: 611–8.
  • Appel GB, Gee B, Kashgarian M, Hayslett JP. Wegen-er's granulomatosis-clinical-pathologic correlations and long-term course. Am J Kidney Dis 1981; 1: 27–37.
  • Franssen CF, Stegeman CA, Oost-Kort WW, Kallenberg CG, Limburg PC, Tiebosch A, et al. Determinants of renal outcome in anti-myeloperoxidase-associated ne-crotizing crescentic glomerulonephritis. J Am Soc Nephrol 1998; 9: 1915–23.
  • Andrassy K, Erb A, Koderisch J, Waldherr R, Ritz E. Wegener's granulomatosis with renal involvement: patient survival and correlations between initial renal function, renal histology, therapy and renal outcome. Chin Nephrol 1991; 35: 139–47.
  • Gans RO, Kuizinga MC, Goldschmeding R, Assmann K, Huysmans FT, Gerlag PG, et al. Clinical features and outcome in patients with glomerulonephritis and anti-neutrophil cytoplasmic autoantibodies. Nephron 1993; 64: 182–8.
  • Ferrario F, Rastaldi MP, D'Amico G. The crucial role of renal biopsy in the management of ANCA-associated renal vasculitis. Nephrol Dial Transplant 1996; 11: 726–8.
  • Bajema IM, Hagen EC, Hermans J, Noel LH, Waldherr R, Ferrario F, et al. Kidney biopsy as a predictor for renal outcome in ANCA-associated necrotizing glomerulo-nephritis. Kidney Int 1999; 56: 1751–8.
  • Aasarod K, Bostad L, Hammerstrom J, Jorstad S, Iversen BM. Renal histopathology and clinical course in 94 patients with Wegener's granulomatosis. Nephrol Dial Transplant 2001; 16: 953–60.
  • Hagen EC, de Keizer RJ, Andrassy K, van Boven WP, Bruijn JA, van Es LA, et al. Compassionate treatment of Wegener's granulomatosis with rabbit anti-thymocyte globulin. Clin Nephrol 1995; 43: 351–9.
  • Tatsis E, Schnabel A, Gross WL. Interferon-alpha treatment of four patients with the Churg-Strauss syndrome. Ann Intern Med 1998; 129: 370–4.
  • Nowack R, Gobel U, Klooker P, Hergesell 0, Andrassy K, van der Woude FJ. Mycophenolate mofetil for maintenance therapy of Wegener's granulomatosis and microscopic polyangiitis: a pilot study in 11 patients with renal involvement. J Am Soc Nephrol 1999; 10: 1965–71.
  • Jayne DR, Chapel H, Adu D, Misbah S, O'Donoghue D, Scott D, et al. Intravenous immunoglobulin for ANCA-associated systemic vasculitis with persistent disease activity. Q J Med 2000; 93: 433–9.
  • Huang XR, Holdsworth SR, Tipping PG. Evidence for delayed-type hypersensitivity mechanisms in glomerular crescent formation. Kidney Int 1994; 46: 69–78.
  • Muchaneta-Kubara EC, el Nahas AM. Myofibroblast phenotypes expression in experimental renal scarring. Nephrol Dial Transplant 1997; 12: 904–15.
  • Gabbiani G. The biology of the myofibroblast. Kidney Int 1992; 41: 530–2.
  • Desmouliere A, Geinoz A, Gabbiani F, Gabbiani G. Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibro-blasts and in quiescent and growing cultured fibroblasts. J Cell Biol 1993; 122: 103–11.
  • Witzgall R, Brown D, Schwarz C, Bonventre JV. Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells. J Chin Invest 1994; 93: 2175–88.
  • Leavitt RY, Fauci AS, Bloch DA, Michel BA, Hunder GG, Arend WP, et al. The American College of Rheumatology 1990 criteria for the classification of Wegener's granulomatosis. Arthritis Rheum 1990; 33: 1101–7.
  • Altman DG. Comparing groups-continuous data. In: Altman DG, editor. Practical statistics for medical research. London: Chapman & Hall; 1997. pp. 179–276.
  • Churg J, Bernstein J, Glassock RJ. Diffuse crescentic glomerulonephritis. In: Churg J, editor. Renal disease. Classification and atlas of glomerular diseases. New York: Igaku-Shoin; 1995. pp. 133–7.
  • Atkins RC, Holdsworth SR, Glasgow EF, Matthews FE. The macrophage in human rapidly progressive glom-erulonephritis. Lancet 1976; i: 830–2.
  • Atkins RC. Macrophages in renal injury. Am J Kidney Dis 1998; 31: XLV- XLVII.
  • Rastaldi MP, Ferrario F, Crippa A, Dell'Antonio G, Casartelli D, Grillo C, et al. Glomerular monocyte-macrophage features in ANCA-positive renal vasculitis and cryoglobulinemic nephritis. J Am Soc Nephrol 2000; 11: 2036–43.
  • Nathan CF. Secretory products of macrophages. J Chin Invest 1987; 79: 319–26.
  • Schena FP, Gesualdo L, Grandaliano G, Montinaro V. Progression of renal damage in human glomerulonephri-tides: is there sleight of hand in winning the game? Kidney Int 1997; 52: 1439–57.
  • Oite T, Shimizu F, Kagami S, Morioka T. Hapten-specific cellular immune response producing glomerular injury. Chin Exp Immunol 1989; 76: 463–8.
  • Nishikawa K, Linsley PS, Collins AB, Stamenkovic I, McCluskey RT, Andres G. Effect of CTLA-4 chimeric protein on rat autoimmune anti-glomerular basement membrane glomerulonephritis. Eur J Immunol 1994; 24: 1249–54.
  • Bolton WK, Innes DJ Jr, Sturgill BC, Kaiser DL. T-cells and macrophages in rapidly progressive glomeruloneph-ritis: clinicopathologic correlations. Kidney Int 1987; 32: 869–76.
  • Neale TJ, Tipping PG, Carson SD, Holdsworth SR. Participation of cell-mediated immunity in deposition of fibrin in glomerulonephritis. Lancet 1988; ii: 421–4.
  • Mathieson PW, Lockwood CM, Oliveira DB. T and B cell responses to neutrophil cytoplasmic antigens in systemic vasculitis. Chin Immunol Immunopathol 1992; 63: 135–41.
  • Brouwer E, Stegeman CA, Huitema MG, Limburg PC, Kallenberg CG. T cell reactivity to proteinase 3 and myeloperoxidase in patients with Wegener' s granulo-matosis (WG). Chin Exp Immunol 1994; 98: 448–53.
  • Christensson M, Pettersson E, Sundquist KG, Christens-son B. T cell activation in patients with ANCA-associated vasculitis: inefficient immune suppression by therapy. Clin Nephrol 2000; 54: 435–42.
  • Tipping PG, Huang XR, Qi M, Van GY, Tang WW. Crescentic glomerulonephritis in CD4- and CD8-defi-cient mice. Requirement for CD4 but not CD8 cells. Am J Pathol 1998; 152: 1541–8.
  • Kawasaki K, Yaoita E, Yamamoto T, Kihara I. Depletion of CD8 positive cells in nephrotoxic serum nephritis of WKY rats. Kidney Int 1992; 41: 1517–26.
  • Fujinaka H, Yamamoto T, Feng L, Kawasaki K, Yaoita E, Hirose S, et al. Crucial role of CD8-positive lymphocytes in glomerular expression of ICAM-1 and cytokines in crescentic glomerulonephritis of WKY rats. J Immunol 1997; 158: 4978–83.
  • Schlesier M, Kaspar T, Gutfleisch J, Wolff-Vorbeck G, Peter EDI. Activated CD4 + and CD8 + T-cell subsets in Wegener's granulomatosis. Rheurnatol Int 1995; 14: 213–9.
  • Ikeda M, Tsuru S, Watanabe Y, Kitahara S, Inouye T. Reduced CD4-CD8 T cell ratios in patients with Wegener's granulomatosis. J Clin Lab Immunol 1992; 38: 103–9.
  • Moosig F, Csernok E, Wang G, Gross WL. Costimula-tory molecules in Wegener's granulomatosis (WG): lack of expression of CD28 and preferential up-regulation of its ligands B7-1 (CD80) and B7-2 (CD86) on T cells. Clin Exp Immunol 1998; 114: 113–8.
  • Rastaldi MP, Ferrario F, Tunesi S, Yang L, D'Amico G. Intraglomerular and interstitial leukocyte infiltration, adhesion molecules, and interleukin-1 alpha expression in 15 cases of antineutrophil cytoplasmic autoantibody-associated renal vasculitis. Am J Kidney Dis 1996; 27: 48–57.
  • Ferrario F, Rastaldi MP. Necrotizing-crescentic glom-erulonephritis in ANCA-associated vasculitis: the role of monocytes. Nephrol Dial Transplant 1999; 14: 1627–31.
  • Heptinstall RH. Crescentic glomerulonephritis. In: Heptinstall RH, editor. Pathology of the kidney. Boston, MA: Little, Brown; 1992. pp. 627–75.
  • Silva FG, Hoyer JR, Pirani CL. Sequential studies of glomerular crescent formation in rats with antiglomer-ular basement membrane-induced glomerulonephritis and the role of coagulation factors. Lab Invest 1984; 51: 404–15.
  • Boucher A, Droz D, Adafer E, Noel LH. Relationship between the integrity of Bowman's capsule and the composition of cellular crescents in human crescentic glomerulonephritis. Lab Invest 1987; 56: 526–33.
  • Holzman LB, Wiggins RC. Consequences of glomerular injury. Glomerular crescent formation. Semin Nephrol 1991; 11: 346–53.
  • Lan HY, Nikolic-Paterson DJ, Atkins RC. Involvement of activated periglomerular leukocytes in the rupture of Bowman's capsule and glomerular crescent progression in experimental glomerulonephritis. Lab Invest 1992; 67: 743–51.
  • Coimbra T, Wiggins R, Noh JW, Merritt S, Phan SH. Transforming growth factor-beta production in anti-glomerular basement membrane disease in the rabbit. Am J Pathol 1991; 138: 223–34.
  • Johnson RJ, Iida H, Alpers CE, Majesky MW, Schwartz SM, Pritzi P, et al. Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis. Alpha-smooth muscle actin is a marker of mesangial cell proliferation. J Clin Invest 1991; 87: 847–58.
  • Alpers CE, Hudkins KL, Gown AM, Johnson RJ. Enhanced expression of "muscle-specific" actin in glomerulonephritis. Kidney Int 1992; 41: 1134–42.
  • Goumenos D, Tsomi K, Iatrou C, Oldroyd S, Sungur A, Papaioannides D et al. Myofibroblasts and the progres-sion of crescentic glomerulonephritis. Nephrol Dial Transplant 1998; 13: 1652–61.
  • Nouwen EJ, Verstrepen WA, Buyssens N, Thu MQ, De Broe ME. Hyperplasia, hypertrophy, and phenotypic alterations in the distal nephron after acute proximal tubular injury in the rat. Lab Invest 1994; 70: 479–93.
  • Jenkins MK, Johnson JG. Molecules involved in T-cell costimulation. Curr Opin Immunol 1993; 5: 361–7.
  • June CH, Bluestone JA, Nadler LM, Thompson CB. The B7 and CD28 receptor families. Immunol Today 1994; 15: 321–31.
  • Lan HY, Nikolic-Paterson DJ, Mu W, Vannice JL, Atkins RC. Interleukin-1 receptor antagonist halts the progression of established crescentic glomerulonephritis in the rat. Kidney Int 1995; 47: 1303–9.
  • Border WA, Okuda S, Languino LR, Sporn MB, Ruoslahti E. Suppression of experimental glomerulo-nephritis by antiserum against transforming growth factor beta 1. Nature 1990; 346: 371–4.
  • Border WA, Noble NA, Yamamoto T, Harper JR, Yamaguchi Y, Pierschbacher MD, et al. Natural inhibitor of transforming growth factor-beta protects against scarring in experimental kidney disease. Nature 1992; 360: 361–4.
  • Badid C, Vincent M, McGregor B, Melin M, Hadj-Aissa A, Veysseyre C, et al. Mycophenolate mofetil reduces myofibroblast infiltration and collagen III deposition in rat remnant kidney. Kidney Int 2000; 58: 51–61.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.