Bax and Bcl-2 are focally overexpressed in the normal epithelium of cancerous prostates

References

• Nelson WG, De Marzo AM, Isaacs WB. Prostate cancer. N Engl J Med 2003; 349: 366–81
   PubMed Web of Science ®Google Scholar
• Gleason DF. Histologic grading of prostate cancer: a perspective. Hum Pathol 1992; 23: 273–9
   PubMed Web of Science ®Google Scholar
• Bostwick DG, Qian J. High-grade prostatic intraepithelial neoplasia. Mod Pathol 2004; 17: 360–79
   PubMed Web of Science ®Google Scholar
• De Marzo AM, Marchi VL, Epstein JI, Nelson WG. Proliferative inflammatory atrophy of the prostate: implications for prostatic carcinogenesis. Am J Pathol 1999; 155: 1985–92
   PubMed Web of Science ®Google Scholar
• Ashida S, Nakagawa H, Katagiri T, Furihata M, Iiizumi M, Anazawa Y, et al. Molecular features of the transition from prostatic intraepithelial neoplasia (PIN) to prostate cancer: genome-wide gene-expression profiles of prostate cancers and PINs. Cancer Res 2004; 64: 5963–72
   PubMed Web of Science ®Google Scholar
• Malins DC, Gilman NK, Green VM, Wheeler TM, Barker EA, Vinson MA, et al. Metastatic cancer DNA phenotype identified in normal tissues surrounding metastasizing prostate carcinomas. Proc Natl Acad Sci U S A 2004; 101: 11428–31
   PubMed Web of Science ®Google Scholar
• Yu YP, Landsittel D, Jing L, Nelson J, Ren B, Liu L, et al. Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancy. J Clin Oncol 2004; 22: 2790–9
   PubMed Web of Science ®Google Scholar
• Krajewska M, Krajewski S, Epstein JI, Shabaik A, Sauvageot J, Song K, et al. Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancers. Am J Pathol 1996; 148: 1567–76
   PubMed Web of Science ®Google Scholar
• Johnson MI, Robinson MC, Marsh C, Robson CN, Neal DE, Hamdy FC. Expression of Bcl-2, Bax, and p53 in high-grade prostatic intraepithelial neoplasia and localized prostate cancer: relationship with apoptosis and proliferation. Prostate 1998; 37: 223–9
   PubMed Web of Science ®Google Scholar
• Stattin P, Damber JE, Karlberg L, Nordgren H, Bergh A. Bcl-2 immunoreactivity in prostate tumorigenesis in relation to prostatic intraepithelial neoplasia, grade, hormonal status, metastatic growth and survival. Urol Res 1996; 24: 257–64
   PubMedGoogle Scholar
• Karaburun Paker S, Kilicarslan B, Ciftcioglu AM, Oztekin S, Sargin FC, Erdogru T, et al. Relationship between apoptosis regulator proteins (bcl-2 and p53) and GL score in prostate cancer. Pathol Oncol Res 2001; 7: 209–12
   PubMedGoogle Scholar
• Furuya Y, Krajewski S, Epstein JI, Reed JC, Isaacs JT. Expression of bcl-2 and the progression of human and rodent prostatic cancers. Clin Cancer Res 1996; 2: 389–98
   PubMed Web of Science ®Google Scholar
• McDonnell TJ, Troncoso P, Brisbay SM, Logothetis C, Chung LW, Hsieh JT, et al. Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer. Cancer Res 1992; 52: 6940–4
   PubMed Web of Science ®Google Scholar
• Tu H, Jacobs SC, Borkowski A, Kyprianou N. Incidence of apoptosis and cell proliferation in prostate cancer: relationship with TGF-beta1 and bcl-2 expression. Int J Cancer 1996; 69: 357–63
   PubMed Web of Science ®Google Scholar
• Baltaci S, Orhan D, Ozer G, Tolunay O, Gogous O. Bcl-2 proto-oncogene expression in low- and high-grade prostatic intraepithelial neoplasia. BJU Int 2000; 85: 155–9
   PubMed Web of Science ®Google Scholar
• Haussler O, Epstein JI, Amin MB, Heitz PU, Hailemariam S. Cell proliferation, apoptosis, oncogene, and tumor suppressor gene status in adenosis with comparison to benign prostatic hyperplasia, prostatic intraepithelial neoplasia, and cancer. Hum Pathol 1999; 30: 1077–86
   PubMed Web of Science ®Google Scholar
• Haggman MJ, Macoska JA, Wojno KJ, Oesterling JE. The relationship between prostatic intraepithelial neoplasia and prostate cancer: critical issues. J Urol 1997; 158: 12–22
   PubMed Web of Science ®Google Scholar
• Kononen J, Bubendorf L, Kallioniemi A, Barlund M, Schraml P, Leighton S, et al. Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med 1998; 4: 844–7
   PubMed Web of Science ®Google Scholar
• Nocito A, Kononen J, Kallioniemi OP, Sauter G. Tissue microarrays (TMAs) for high-throughput molecular pathology research. Int J Cancer 2001; 94: 1–5
   PubMed Web of Science ®Google Scholar
• Merseburger AS, Kuczyk MA, Serth J, Bokemeyer C, Young DY, Sun L, et al. Limitations of tissue microarrays in the evaluation of focal alterations of bcl-2 and p53 in whole mount derived prostate tissues. Oncol Rep 2003; 10: 223–8
   PubMed Web of Science ®Google Scholar
• Zeng L, Rowland RG, Lele SM, Kyprianou N. Apoptosis incidence and protein expression of p53, TGF-beta receptor II, p27Kip1, and Smad4 in benign, premalignant, and malignant human prostate. Hum Pathol 2004; 35: 290–7
   PubMed Web of Science ®Google Scholar
• Yang G, Wheeler TM, Kattan MW, Scardino PT, Thompson TC. PI of prostate carcinoma cells is associated with reduced apoptotic index. Cancer 1996; 78: 1267–71
   PubMed Web of Science ®Google Scholar
• Grzmil M, Thelen P, Hemmerlein B, Schweyer S, Voigt S, Mury D, et al. Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells. Am J Pathol 2003; 163: 543–52
   PubMed Web of Science ®Google Scholar
• Krajewska M, Krajewski S, Banares S, Huang X, Turner B, Bubendorf L, et al. Elevated expression of inhibitor of apoptosis proteins in prostate cancer. Clin Cancer Res 2003; 9: 4914–25
   PubMed Web of Science ®Google Scholar
• Satoh F, Mimata H, Nomura T, Fujita Y, Shin T, Sakamoto S, et al. Autocrine expression of neurotrophins and their receptors in prostate cancer. Int J Urol 2001; 8: S28–34
   PubMed Web of Science ®Google Scholar
• Garcia-Tunon I, Ricote M, Ruiz A, Fraile B, Paniagua R, Royuela M. IL-6, its receptors and its relationship with bcl-2 and bax proteins in infiltrating and in situ human breast carcinoma. Histopathology 2005; 47: 82–9
   PubMed Web of Science ®Google Scholar