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Spectroscopy Letters
An International Journal for Rapid Communication
Volume 23, 1990 - Issue 7
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Original Articles

2D-NMR Studies on Bis(Amidinohydrazones). I. A Proton-Carbon Heteronuclear Shift Correlation Study on the Enzyme Inhibitors Methylpropylglyoxal Bis(Amidinohydrazone) and Butylmethylglyoxal Bis(Amidinohydrazone)

Pages 877-885 | Received 04 Apr 1990, Accepted 05 May 1990, Published online: 24 Oct 2006

References

  • Williams-Ashman , HG. and Schenone , A. 1972 . Methyl Glyoxal Bis(guanylhydrazone) as a Potent Inhibitor of Mammalian and Yeast S-Adenosylmethionine Decarboxylases . Biochem. Biophys. Res. Commun. , 46 : 288
  • Corti , A. , Dave , C. , Williams-Ashman , HG. , Mihich , E. and Schenone , A. 1974 . Specific Inhibition of the Enzymic Decarboxylation of S-Adenosylmethionine by Methylglyoxal Bis(guanylhydrazone) and Related Substances . Biochem. J. , 139 : 351
  • Seppänen , P. , Fagerström , R. , Alhonen-Hongisto , L. , Elo , H. , Lumme , P. and Jänne , J. 1984 . Glyoxal Bis(guanylhydrazone) as an Inhibitor of Polyamine Biosynthesis in Tumour Cells . Biochem. J. , 221 : 483
  • Elo , H. , Laine , R. , Alhonen-Hongisto , L. , Jänne , J. , Mutikainen , I. and Lumme , P. 1985 . Biochemical Characterization of Propylglyoxal Bis(guanylhydrazone). Facile Synthesis of Monoalkylglyoxal Bis(guanylhydrazones) . Z. Naturforsch. , 40c : 839
  • Elo , H. , Mutikainen , I. , Alhonen-Hongisto , L. , Laine , R. , Jänne , J. and Lumme , P. 1986 . Biochemical Properties and Crystal Structure of Ethylmethylglyoxal Bis(guanylhydrazone) Sulfate - an Extremely Powerful Novel Inhibitor of Adenosylmethionine Decarboxylase . Z. Naturforsch. , 41c : 851
  • Elo , H. , Mutikainen , I. , Alhonen-Hongisto , L. , Laine , R. and Jänne , J. 1988 . Diethylglyoxal Bis(guanylhydrazone): a Novel Highly Potent Inhibitor of S-Adenosylmethionine Decarboxylase with Promising Properties for Potential Chemotherapeutic use . Cancer Lett. , 41 : 21
  • Elo , H. 1989 . Bis(amidinohydrazones) [‘Bis(guanylhydrazones)’] as Antineoplastic Agents. Chemical and Biochemical Studies , Ph.D. Thesis Helsinki, , Finland : Department of Biochemistry, University of Helsinki . and references therein
  • Freedlander , BL. and French , FA. 1958 . Carcinostatic Action of Polycarbonyl Compounds and Their Derivatives. II. Glyoxal Bis(guanylhydrazone) and Derivatives . Cancer Res. , 18 : 360
  • Freireich , EJ. , Frei , E. and Karon , M. 1962 . Methylglyoxal Bis(guanylhydrazone): A New Agent Active Against Acute Myelocytic Leukemia . Cancer Res. , 16 : 183
  • Elo , H. 1989 . Proton Nuclear Magnetic Resonance Spectroscopy of Bis(amidinohydrazones) (Bis(guanylhydrazones)), and Its Use for Studies on the Isomerism and Tautomerism of the Compounds . Spectroscopy Letters , 22 : 123
  • Elo , H. 1989 . Carbon-13 NMR Spectroscopy of the Antileukemic Drug MGBG and Related Bis(amidinohydrazones) [‘Bis(guanylhydrazones)’] . Spectroscopy Letters , 22 : 161
  • Elo , H. and Soljamo , K. 1989 . Unambiguous Assignment of the 13C NMR Resonances of the Side-Chain Carbon Atoms of Dipropylglyoxal Bis(amidinohydrazone) by DEPT and Selective Heteronuclear Proton Decoupling Techniques . Spectroscopy Lett. , 22 : 1141

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