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Spectroscopy Letters
An International Journal for Rapid Communication
Volume 25, 1992 - Issue 8
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Original Articles

Substituent Effects in the Carbon NMR of Aliphatic bis(Amidinohydrazones) ['Bis(Guanylhydrazones)']. Construction of a set of Quantitative Empirical Rules. Unambiguous Assignment of Several Previously Unassigned Carbon Resonances

Pages 1267-1296 | Received 10 Jun 1992, Accepted 15 Jul 1992, Published online: 23 Sep 2006

References

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  • Williams-Ashman , H. G. and Seidenfeld , J. 1986 . Aspects of the Biochemical Pharmacology of Methylglyoxal Bisguanylhydrazone . Biochem. Pharmacol. , 35 : 1217
  • Jänne , J. , Alhonen-Hongisto , L. , Nikula , P. and Elo , H. 1986 . S-Adenosylmethionine Decarboxylase as Target of Chemotherapy . Adv. Enz. Regul. , 24 : 125 and references therein
  • Elo , H. 1989 . “ Bis(amidinohydrazones) [‘Bis(guanylhydrazones)’] as Antineoplastic Agents. Chemical and Biochemical Studies ” . In Ph.D. Thesis , Helsinki, , Finland : Department of Biochemistry, University of Helsinki . and references therein
  • Elo , H. , Laine , R. , Alhonen-Hongisto , L. , Jänne , J. , Mutikainen , I. and Lumme , P. 1985 . Biochemical Characterization of Propylglyoxal Bis(guanylhydrazone). Facile Synthesis of Monoalkylglyoxal Bis(guanylhydrazones) . Z. Naturforsch. , 40c : 839
  • Elo , H. , Mutikainen , I. , Alhonen-Hongisto , L , Laine , R. , Jänne , J. and Lumme , P. 1986 . Biochemical Properties and Crystal Structure of Ethylmethylglyoxal Bis(guanylhydrazone) Sulfate - an Extremely Powerful Novel Inhibitor of Adenosylmethionine Decarboxylase . Z. Naturforsch. , 41c : 851
  • Elo , H. , Mutikainen , I. , Alhonen-Hongisto , L. , Laine , R. and Jänne , J. 1988 . Diethylglyoxal Bis(guanylhydrazone): a Novel Highly Potent Inhibitor of S-Adenosylmethionine Decarboxylase with Promising Properties for Potential Chemotherapeutic use . Cancer Lett. , 41 : 21
  • Elo , H. and Mutikainen , I. 1988 . Biochemical and Chemical Characterization of Trifluoromethylglyoxal Bis(guanylhydrazone), a Close Analog of the Antileukemic Drug Mitoguazone . Z. Naturforsch , 43c : 601
  • Elo , H. 1990 . Adenosylmethionine Decarboxylase Inhibitors - Lack of Activity Against Cytopathic Effects of HIV. Chemotherapy , 36 : 373
  • Elo , H. O. , Tilus , P. T.E. , Mutikainen , I. P. , Heikkinen , I. and Riekkola , M.-L. 1989 . Remarkable Differences Between the Species Distributions of Various Bis(guanylhydrazones) at Physiological Conditions, and Their Possible Involvement in the Strict Structural Requirements for Antileukemic Activity . Anti-Cancer Drug Des. , 4 : 303
  • Lumme , P. O. , Mutikainen , I. and Elo , H. O. 1986 . Structure of Propylglyoxal Bis(amidinohydrazone) Sulfate Dihydrate . Acta Cryst. , C42 : 1209
  • Elo , H. 1989 . Proton Nuclear Magnetic Resonance Spectroscopy of Bis(amidinohydrazones) (Bis(guanylhydrazones)), and Its Use for Studies on the Isomerism and Tautomerism of the Compounds . Spectroscopy Lett. , 22 : 123
  • Elo , H. 1989 . Carbon-13 NMR Spectroscopy of the Antileukemic Drug MGBG and Related Bis(amidinohydrazones) [‘Bis(guanylhydrazones)’] . Spectroscopy Lett. , 22 : 161
  • Elo , H. and Soljamo , K. 1989 . Unambiguous Assignment of the 13C NMR Resonances of the Side-Chain Carbon Atoms of Dipropylglyoxal Bis(amidinohydrazone) by DEPT and Selective Heteronuclear Proton Decoupling Techniques . Spectroscopy Lett. , 22 : 1141
  • Elo , H. 1990 . 2D-NMR Studies on Bis(amidinohydrazones). I. A Proton-Carbon Heteronuclear Shift Correlation Study on the Enzyme Inhibitors Methylpropylglyoxal Bis(amidinohydrazone) and Butylmethylglyoxal Bis(amidinohydrazone) . Spectroscopy Lett. , 23 : 877
  • Mutikainen , I. , Elo , H and Lumme , P. 1986 . Crystal and molecular structure of glyoxal bis(amidinohydrazone) dihydrochloride; biochemical aspects . J. Chem. Soc., Perkin Trans. II , : 291
  • Abraham , R. J. and Loftus , P. 1981 . Proton and Carbon-13 NMR Spectroscopy, An Integrated Approach , 24 – 33 . London - Philadelphia-Rheine : Heyden .
  • Soljamo , K. and Elo , H. Spectroscopy Lett. , Manuscript submitted for publication
  • Elo , H. and Soljamo , K. Manuscript to be submitted for publication
  • Elo , H. and Pagelot , A. Manuscript in preparation

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