Publication Cover
Spectroscopy Letters
An International Journal for Rapid Communication
Volume 25, 1992 - Issue 8
6
Views
3
CrossRef citations to date
0
Altmetric
Original Articles

Studies on the Spin-Lattice Relaxation Times of the Carbons of the Investigational Antileukemic Drug and Enzyme Inhibitor Methylglyoxal Bis(Amidino-Hydrazone) ['Methylglyoxal BIS(Guanylhydrazone)'] and Its Dialkylglyoxal Analogs

&
Pages 1315-1332 | Received 10 Jun 1992, Accepted 16 Jul 1992, Published online: 23 Sep 2006

References

  • Alhonen-Hongisto , L. , Seppänen , P. , Nikula , P. , Elo , H. and Jänne , J. 1985 . Structure-Activity Relationship of Bis(guanylhydrazones) . Recent Progress in Polyamine Research , : 261 – 270 . and references therein
  • Williams-Ashman , H. G. and Seidenfeld , J. 1986 . Aspects of the Biochemical Pharmacology of Methylglyoxal Bisguanylhydrazone . Biochem. Pharmacol. , 35 : 1217
  • Jänne , J. , Alhonen-Hongisto , L. , Nikula , P. and Elo , H. 1986 . S-Adenosylmethionine Decarboxylase as Target of Chemotherapy . Adv. Enz. Regul. , 24 : 125 and references therein
  • Elo , H. 1989 . “ Bis(amidinohydrazones) [‘Bis(guanylhydrazones)’] as Antineoplastic Agents. Chemical and Biochemical Studies ” . In Ph.D. Thesis , Helsinki, , Finland : Department of Biochemistry, University of Helsinki . and references therein
  • Elo , H. , Laine , R. , Alhonen-Hongisto , L. , Jänne , J. , Mutikainen , I. and Lumme , P. 1985 . Biochemical Characterization of Propylglyoxal Bis(guanylhydrazone). Facile Synthesis of Monoalkylglyoxal Bis(guanylhydrazones). Z. Naturforsch. , 40c : 839
  • Elo , H. , Mutikainen , I. , Alhonen-Hongisto , L , Laine , R. , Jänne , J. and Lumme , P. 1986 . Biochemical Properties and Crystal Structure of Ethylmethylglyoxal Bis(guanylhydrazone) Sulfate - an Extremely Powerful Novel Inhibitor of Adenosylmethionine Decarboxylase . Z. Naturforsch. , 41c : 851
  • Elo , H. , Mutikainen , I. , Alhonen-Hongisto , L. , Laine , R. and Jänne , J. 1988 . Diethylglyoxal Bis(guanylhydrazone): a Novel Highly Potent Inhibitor of S-Adenosylmethionine Decarboxylase with Promising Properties for Potential Chemotherapeutic use . Cancer Lett. , 41 : 21
  • Elo , H. and Mutikainen , I. 1988 . Biochemical and Chemical Characterization of Trifluoromethylglyoxal Bis(guanylhydrazone), a Close Analog of the Antileukemic Drug Mitoguazone . Z. Naturforsch. , 43c : 601
  • Elo , H. 1990 . Adenosylmethionine Decarboxylase Inhibitors - Lack of Activity Against Cytopathic Effects of HIV . Chemotherapy , 36 : 373
  • Bis(amidinohydrazones) are commonly called ‘bis(guanylhydrazones)’. Therefore, their established abbreviations contain the letters GBG, preceded by an indication of the substituents (e.g., DE for diethyl or EM for ethyl methyl). The term ‘bis(amidinohydrazone)’ is, however, more appropriate. The Chemical Abstracts' systematic name for methylglyoxal bis(amidinohydrazone) is 2,2′-(1-methyl-1,2-ethanediylidene)bis(hydrazinecarboximidamide), and other congeners are named analogously
  • Elo , H. O. , Tilus , P. T.E. , Mutikainen , I. P. , Heikkinen , I. and Riekkola , M.-L. 1989 . Remarkable Differences Between the Species Distributions of Various Bis(guanylhydrazones) at Physiological Conditions, and Their Possible Involvement in the Strict Structural Requirements for Antileukemic Activity . Anti-Cancer Drug Des. , 4 : 303
  • Lumme , P. O. , Mutikainen , I. and Elo , H. O. 1986 . Structure of Propylglyoxal Bis(amidinohydrazone) Sulfate Dihydrate . Acta Cryst. , C42 : 1209
  • Elo , H. 1989 . Proton Nuclear Magnetic Resonance Spectroscopy of Bis(amidinohydrazones) (Bis(guanylhydrazones)), and Its Use for Studies on the Isomerism and Tautomerism of the Compounds . Spectroscopy Letters , 22 : 123
  • Elo , H. 1989 . Carbon-13 NMR Spectroscopy of the Antileukemic Drug MGBG and Related Bis(amidinohydrazones) [‘Bis(guanylhydrazones)’] . Spectroscopy Letters , 22 : 161
  • Elo , H. and Soljamo , K. 1989 . Unambiguous Assignment of the 13C NMR Resonances of the Side-Chain Carbon Atoms of Dipropylglyoxal Bis(amidinohydrazone) by DEPT and Selective Heteronuclear Proton Decoupling Techniques . Spectroscopy Lett. , 22 : 1141
  • Elo , H. 1990 . 2D-NMR Studies on Bis(amidinohydrazones). I. A Proton-Carbon Heteronuclear Shift Correlation Study on the Enzyme Inhibitors Methylpropylglyoxal Bis(amidinohydrazone) and Butylmethylglyoxal Bis(amidinohydrazone) . Spectroscopy Lett. , 23 : 877
  • Elo , H. and Soljamo , K. Manuscript to be submitted for publication
  • Elo , H. Manuscript to be submitted for publication
  • Mutikainen , I. , Elo , H. and Lumme , P. 1986 . Crystal and molecular structure of glyoxal bis(amidinohydrazone) dihydrochloride; biochemical aspects . J. Chem. Soc., Perkin Trans. II , : 291
  • Hamilton , W. C. and La Placa , S. J. 1968 . The Crystal and Molecular Structure of an Anti-Leukemia Drug: Methylglyoxal Bisguanylhydrazone Dihydrochloride Monohydrate, C5N8H12.2HCl.H2O. Neutron and X-Ray Diffraction Studies . Acta Cryst. , B24 : 1147
  • Edmonds , J. W. and Hamilton , W. C. 1972 . The Crystal and Molecular Structure of Dimethylglyoxal Bisguanylhydrazone Dihydrochloride Dihydrate, C6H14N8.2HCl.2H2O . Acta Cryst. , B28 : 1362
  • Mutikainen , I. , Elo , H. and Tilus , P. Manuscript in preparation

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.