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- One measure of nucleophilicity is pKa. The pKaof N-methylaniline is 4.85, while the pKaof morpholine is 8.33, a nearly 10,000 fold difference
- Interestingly, for halogen substitution in the meta and/or para positions of the phenyl ring, the reaction proceeded smoothly, but for ortho substitution the main product was not the ethyl carbamoyl acetate, but apparently a cyclized product lacking the halogen (unpublished results, T. Tojo, G. Spears)
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