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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 35, 2005 - Issue 17
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Original Articles

Improved Experimental Procedure for the Synthesis of the Potent MEK Inhibitor PD184352

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Pages 2265-2269 | Received 15 Dec 2004, Published online: 18 Aug 2006

References

  • Bridges , A. J. Method of Treating or Preventing Septic Shock by Administering a MEK inhibitor . Intl. Patent WO98/37881 . September 3, 1998 .
  • Barrett , S. , Bridges , A. J. , Doherty , A. M. , Dudley , D. T. and Saltiel , A. R. 4‐Bromo or 4‐Iodo Phenylamino Benzhydroxamic Acid Derivatives and their use as MEK Inhibitors . Intl. Patent WO99/01426 . January 14, 1999 .
  • Johnson , G. , Boxer , P. A. , Drummond , J. T. , Boyd , D. K. and Anderson , R. J. 1989 . Identification and evaluation of o‐alkyl susbtituted hydroxamic acids as potent in vitro inhibitors of the hepatic glycine cleavage system and investigation of their action on in vivo central nervous system glycine concentration . Arzneim.‐Forsch./Drug Res. , 39 ( 1 ) : 432 – 437 .
  • Bain , J. and Cohen , P. The MEK inhibitory activity shown by pyrrolidine amide 9 was ten fold lower than that exhibited by PD184352. Personal communication
  • Tripathy , N. K. and Georg , G. I. 2004 . RCM approach for the total synthesis of cryptophycin‐24 (arenastatin A) . Tetrahedron Lett. , 45 ( 27 ) : 5309 – 5311 .

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