Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 38, 2008 - Issue 2
440
Views
3
CrossRef citations to date
0
Altmetric
Original Articles

Concise and Efficient Synthesis of Highly Potent and Selective Dipeptidyl Peptidase II Inhibitors

, , , , &
Pages 162-169 | Received 02 Jul 2007, Published online: 18 Jan 2008

References

  • Villhauer , E. B. , Brinkman , J. A. , Naderi , G. B. , Burkey , B. F. , Dunning , B. E. , Prasas , K. , Mangold , B. L. , Russel , M. E. and Hughes , T. E. 2003 . 1‐[3‐Hydroxy‐1‐adamantyl)amino]acetyl]‐2‐cyano‐(S)‐pyrrolidine: A potent, selective and orally bioavailable dipetidyl peptidase IV inhibitor with antihyperglycemic properties . J. Med. Chem. , 46 : 2774 – 2789 .
  • Augustyns , K. , Van der Veken , P. , Senten , K. and Haemers , A. 2003 . Dipeptidyl peptidase IV inhibitors as new therapeutic agents in the treatment of type II diabetes . Expert Opin. Ther. Pat. , 13 ( 4 ) : 499 – 510 .
  • Drucker , D. J. 2003 . Therapeutic potential of dipeptidyl peptidase IV inhibitors for the treatment of type II diabetes . Expert Opin. Invest. Drugs. , 12 : 87 – 100 .
  • Senten , K. , Van der Veken , P. , De Meester , I. , Lambeir , A. M. , Scharpe , S. , Haemers , A. and Augustyns , K. 2003 . Design, synthesis, and SAR of potent and selective dipeptide‐derived inhibitors for dipeptidyl peptidases . J. Med. Chem. , 46 : 5005 – 5014 .
  • Senten , K. , Van der Veken , P. , De Meester , I. , Lambeir , A. M. , Scharpe , S. , Haemers , A. and Augustyns , K. 2004 . γ‐Amino‐substituted analogues of 1‐[(S)‐2,4‐diaminobutanoyl]piperidine as highly potent and selective dipeptidyl peptidase II inhibitors . J. Med. Chem. , 47 : 2906 – 2916 .
  • Scharpe , S. , Gustyns , K. , Haemers , A. , Lambeir , A. M. , Demeester , I. , Senten , K. and Van Der Veken , P. Inhibitors of proline‐specific dipeptidyl peptidases: DPP IV inhibitors as a novel approach for the treatment of type 2 diabetes . WO2004076434 . 10/09/2004 .
  • Radhakrishna , A. S. , Parham , M. E. , Riggs , R. M. and Loudon , G. M. 1979 . New method for direct conversion of amides to amines . J. Org. Chem. , 44 : 1746
  • Waki , M. , Kitajima , Y. and Izumiya , N. 1981 . A facile synthesis of N 2‐protected L‐2,3‐diaminopropanoic acid . Synthesis , 4 : 266
  • Merrick , R. , Almond , J. B. , Stimmel , E. , Thompson , A. and Loudon , G. M. 1993 . Hofmann rearrangement under mildly acidic conditions using [1,1‐bis(trifluoroacetoxy)]iodobenzene . Org. Synth. Coll. , 8 : 132

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.