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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 38, 2008 - Issue 20
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Original Articles

Synthesis and Characterization of Metabolites and Potential Impurities of Lansoprazole, an Antiulcerative Drug

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Pages 3477-3489 | Received 26 Dec 2007, Published online: 29 Sep 2008

REFERENCES

  • Wallmark , B. ; Lorentzon , B. ; Larsson , H. The mechanism of action of omeprazole—A survey of its inhibitory actions in vitro . J. Gastroenterol. 1985 , 20 ( 108 ), 37 – 51 .
  • Larsson , H. ; Carlsson , E. ; Junggren , U. ; Olbe , I. ; Sjostrand , S. E. ; Skanberg , I. ; Sundell , G. Inhibition of gastric acid secretion by omeprazole in the dog and rat . Gastroenterology 1983 , 85 , 900 – 907 .
  • Barradell , L. B. ; Faulds , D. ; McTavish , D. A review of its paharmacodynamic and pharmacokinetic properties and its therapeutic efficacy in acid-related disorders . Drugs 1992 , 44 , 225 – 250 .
  • Hatlebakk , J. G. ; Berstad , A. ; Carling , L. ; Svedberg , L. E. ; Unge , P. ; Ekstrom , P. ; Halvorsen , L. ; Stallemo , A. ; Hovdenak , N. ; Trondstad , R. ; Kittang , E. ; Lange , O. J. Lansoprazole versus omeprazole in short term treatment of reflux oesophagitis: Results of scandinavian multicentre trial . Scand. J. Gastroenterol. 1993 , 28 , 224 – 228 .
  • Spencer , C. M. ; Faulds , D. Lansoprazole: A reappraisal of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy in acid related disorders . Drugs 1994 , 48 ( 3 ), 404 – 430 .
  • International Conference on Harmonization (ICH) Guidelines, Q3A (R). Impurities in New Drug Substances, February 2002.
  • (a) Sattanathan , P. ; Moses Babu , J. ; Vyas , K. ; Reddy , R. B. ; Rajan , S. T. ; Sudhakar , P. Structural studies of impurities of risperidone by hyphenated techniques . J. Pharm. Biomed. Anal. 2006 , 40 , 598 – 604 ; (b) Reddy, K. M.; Moses Babu, J.; Sudhakar, P.; Sharma, M. S. P.; Reddy, G. S.; Vyas, K. Structural studies of racecadotril and its process impurities by NMR and mass spectroscopy. Pharmazie 2006, 65, 994–998 .
  • (a) El-Sherif , Z. A. ; Mohamed , A. O. ; El-Bardicy , M. G. ; El-Tarras , M. F. Reversed-phase high performance liquid chromatographic method for the determination of lansoprazole, omeprazole and pantoprazole sodium sesquihydrate in the presence of their acid-induced degradation products . Chem. Pharm. Bull. 2006 , 54 , 814 – 818 ; (b) Ekpe, A.; Jacobsen, T. Effect of various salts on stability of lansoprazole, omeprazole and pantoprazole has determined by high performance liquid chromatography. Drug Dev. Ind. Pharm. 1999, 25, 1057–1065; (c) Peres, O.; Oliveira, C. H.; Barrientos-Astigarraga, R. E.; Rezende, V. M.; Mendes, G. P.; De Nucci, G. Determination of pantoprazole in human plasma by LC-MS-MS using lansoprazole as a internal standared. Arzneim.-Forsch./Drug Res. 2004, 54, 314–319; (d) Basavaiah, K.; Ramakrishna, V.; Anilkumar, U. R. Sensitive spectrophotometric determination of lansoprazole in pharmaceutical using ceric ammonium sulphate based on redox and complex formation reactions. Eclet. Quim. 2006, 31 (3), 67–74; (e) Aydogmus, Z. Spectrophotometric methods for the determination of lansoprazole in capsules. Acta Pharm. Sci. 2006, 48(1), 45–54; (f) Prasada Rao, K. V. S. P.; Vijaya Kumar, G.; Vijaya Kumari, K.; Srinivas, L. D.; Prabhakar, G. Reversed phase HPLC estimation of lansoprazole in pure and pharmaceutical formulations. Asian J. Chem. 2006, 18(2), 798–802 .
  • (a) Karol , M. D. ; Granneman , G. R. ; Alexander , K. Determination of lansoprazole and five metabolites in plasma by high performance liquid chromatography. J. Chrom. B: Biomed. Sci. Appl. 1995, 668(1), 182–186; (b) Nannan, C.; Weili, C.; Hongrong, X.; Mi, Z.; Xuening L. LC-MS/MS determination of lansoprazole and its metabolites in human plasma. Yaowu Fenxi Zazhi 2006, 26(1), 35–39.
  • Kubo , K. ; Oda , K. ; Kaneko , T. ; Satoh , H. ; Nohara , A. Synthesis of 2-[[(4-flouroalkoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazoles as antiulecer agents . Chem. Pharm. Bull. 1990 , 38 , 2853 – 2858 .

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