Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 38, 2008 - Issue 15
111
Views
1
CrossRef citations to date
0
Altmetric
Original Articles

Novel Synthesis of Differentially Substituted 5,7-Dialkoxyquinazolin-4-ones

&
Pages 2575-2583 | Received 18 Sep 2007, Published online: 09 Sep 2008

REFERENCES

  • Laird , A. D. ; Cherrington , J. M. Small molecule tyrosine kinase inhibitors: Clinical development of anticancer agents . Expert Opin. Invest. Drugs 2003 , 12 , 51 .
  • Bonomi , P. Erlotinib: A new therapeutic approach for non-small cell lung cancer . Expert Opin. Invest. Drugs 2003 , 12 , 1395 .
  • Ballard , P. ; Bradbury , R. H. ; Harris , C. S. ; Hennequin , L. F. A. ; Hickinson , M. ; Johnson , P. D. ; Kettle , J. G. ; Klinowska , T. ; Leach , A. G. ; Morgentin , R. ; Pass , M. ; Ogilvie , D. J. ; Olivier , A. ; Warin , N. ; Williams , E. J. Inhibitors of epidermal growth factor receptor tyrosine kinase: Novel C-5 substituted anilinoquinazolines designed to target the ribose pocket . Bioorg. & Med. Chem. Letters 2006 , 16 , 1633 – 1637 .
  • Barlaam , B. ; Fennell , M. ; Germain , H. ; Green , T. ; Hennequin , L. ; Morgentin , R. ; Olivier , A. ; Plé , P. ; Vautier , M. ; Costello , G. New heterocyclic analogues of 4-(2-chloro-5-methoxyanilino)quinazolines as potent and selective c-Src kinase inhibitors. Bioorg. & Med. Chem. Letters 2005, 15, 5446–5449.
  • Hennequin , L. F. ; Allen , J. ; Breed , J. ; Curwen , J. ; Fennell , M. ; Green , T. P. ; Lambert-van der Brempt , C. ; Morgentin , R. ; Norman , R. A. ; Olivier , A. ; Otterbein , L. ; Plé , P. ; Warin , N. ; Costello , G. N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-src/abl kinase inhibitor . J. Med. Chem. 2006 , 49 , 6465 – 6488 .
  • Barlaam , B. Preparation of quinazolines non-receptor tyrosine kinase inhibitors as antitumor agents . PCT Int. Appl. WO 2004081000 .
  • Armarego , W. L. F. An improved preparation of phthalazine and quinazoline . J. Appl. Chem. 1961 , 11 , 70 .
  • AstraZeneca; unpublished results .
  • Roth , G. A. ; Tai , J. J. A new synthesis of aryl substituted quinazolin-4(1H)-ones . J. Heterocyclic Chem. 1996 , 33 , 2051 .
  • Fray , M. J. ; Mathias , J. P. ; Nichols , C. L. ; Po-Ba , Y. M. ; Snow , H. Synthesis of substituted 2-amino-4-quinazolinones via (ortho-fluorobenzoyl)guanidines . Tetrahedron Letters 2006 , 47 , 6365 – 6368 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.