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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 39, 2008 - Issue 2
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Original Articles

Efficient Synthesis of Olmesartan Medoxomil, an Antihypertensive Drug

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Pages 291-298 | Received 30 Apr 2008, Published online: 22 Dec 2008

REFERENCES

  • Fukuda , M. ; Yamanaka , T. ; Mizuno , M. ; Motokawa , M. ; Shirasawa , Y. ; Miyagi , S. ; Nishio , T. ; Yoshida , A. ; Kimura , G. Angiotensin II type 1 receptor blocker, olmesartan, restores nocturnal blood pressure decline by enhancing daytime natriuresis . J. Hypertens. 2008 , 26 , 583 – 588 .
  • Yanagisawa , H. ; Amemiya , Y. ; Kanazaki , T. ; Shimoji , Y. ; Fujimoto , K. ; Kitahara , Y. ; Sada , T. ; Mizuno , M. ; Ikeda , M. ; Miyamoto , S. ; Furukawa , Y. ; Koike , H. Nonpeptide angiotensin II receptor antagonists: Synthesis, biological activities, and structure–activity relationships of imidazole-5-carboxylic acids bearing alkyl, alkenyl, and hydroxyalkyl substituents at the 4-position and their related compounds . J. Med. Chem. 1996 , 39 , 323 – 338 .
  • Gardner , S. F. ; Franks , A. M. Olmesartan medoxomil: The seventh angiotensin receptor antagonist . Ann. Pharmacother. 2003 , 37 , 99 – 105 .
  • Babu , K. S. ; Reddy , M. S. ; Tagore , A. R. ; Reddy , G. S. ; Sebastian , S. Process for preparing olmesartan medoxomil. WO 2007/047838 A2, 2007 .
  • Ismail , M. A. H. ; Barker , S. ; Abou El Ella , D. A. ; Abouzid , K. A. M. ; Toubar , R. A. ; Todd , M. H. Design and synthesis of new tetrazolyl- and carboxy-biphenylylmethyl-quinazolin-4-one derivatives as angiotensin II AT1 receptor antagonists . J. Med. Chem. 2006 , 49 , 1526 – 1535 .
  • DRL-IPD Communication No. IPDO-IPM-00114

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