Synthesis and Evaluation of Novel Compounds as Potent Dipeptidyl Peptidase IV Inhibitors

REFERENCES

• (a) Sebokova , E. ; Christ , A. D. ; Boehringer , M. ; Mizraha , J. Dipeptidyl peptidase IV inhibitors: The next generation of new promising therapies for the management of type 2 diabetes . Curr. Top. Med. Chem. 2007 , 7 , 547 – 555 ; (b) Wiedeman , P. E. ; Trevillyan , J. M. Dipeptidyl peptidase IV inhibitors for the trearment of impaired glucose tolerance and type 2 diabetes . Curr. Opin. Investig. Drugs 2003 , 4 , 412 – 420 ; (c) Weber , A. E. Dipeptidyl peptidase IV inhibitors for the treatment of diabetes . J. Med. Chem. 2004 , 47 , 4135 – 4141 .
   PubMed Web of Science ®Google Scholar
• (a) Drucker , D. J. Therapeutic potential of dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes . Expert. Opin. Invest. Drugs 2003 , 12 , 87 – 100 ; (b) Holst , J. J. ; Deacon , C. F. Glucagon-like peptide 1 and inhibitors of dipeptidyl peptidase IV in the treatment of type 2 diabetes mellitus . Curr. Opin. Pharmacol. 2004 , 4 , 589 – 596 ; (c) Drucker , D. J. Biologic actions and therapeutic potential of the proglucagon-derived peptides . Gastroenterology 2002 , 122 , 531 – 544 .
   PubMed Web of Science ®Google Scholar
• (a) Mest , H.-J. ; Mentlein , R. Dipeptidyl peptidase inhibitors as new drugs for the treatment of type 2 diabetes . Diabetologia 2005 , 48 , 616 – 620 ; (b) Ahren , B. ; Simonsson , E. ; Larsson , H. ; Landin-Olsson , M. ; Torgeirsson , H. ; Jansson , P. A. ; Sandqvist , M. ; Bavenholm , P. ; Efendic , S. ; Eriksson , J. W. ; Dickinson , S. ; Holmes , D. Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes . Diabetes Care 2002 , 25 , 869 – 875 .
   PubMed Web of Science ®Google Scholar
• (a) Heins , J. ; Weiker , P. ; Schonlein , C. ; Born , I. ; Hartrodt , B. ; Neubert , K. ; Tsuru , D. ; Barth , A. Mechanism of proline-specific proteinases, I: Substrate specificity of dipeptidyl peptidase IV from pig kidney and proline-specific endopeptidase from Flavobacterium meningosepticum . Biochim. Biophys. Acta 1988 , 954 , 161 – 169 ; (b) Lambeir , A.-M. ; Durinx , C. ; Scharpel , S. ; De Meester , I. Dipeptidyl-peptidase IV from bench to bedside: An update on structural properties, functions, and clinical aspects of the enzyme DPP IV . Crit. Rev. Clin. Lab. Sci. 2003 , 40 , 209 – 294 ; (c) Mentlein , R. Dipeptidyl-peptidase IV (CD26)—Role in the inactivation of regulatory peptides . Regul. Pept. 1999 , 85 , 9 – 24 .
   PubMed Web of Science ®Google Scholar
• Ashworth , D. M. ; Atrash , B. ; Baker , G. R. ; Baxter , A. J. ; Jenkins , P. D. ; Jones , D. M. ; Szelke , M. 2-Cyanopyrrolidides as potent, stable inhibitors of dipeptidyl peptidase IV . Bioorg. Med. Chem. Lett. 1996 , 6 , 1163 – 1166 .
   Web of Science ®Google Scholar
• Peters , J.-U. Eleven years of cyanopyrrolidines as DPP-IV inhibitors . Curr. Top. Med. Chem. 2007 , 7 , 579 – 595 .
   PubMed Web of Science ®Google Scholar
• Tang , P.-C. ; Lin , Z.-G. ; Lv , H.-J. ; Zhao , F.-Q. ; Li , L. Derivatives of azabicyclo octane, the method of making them and the uses thereof as inhibitors of dipeptidyl peptidase IV. WO Patent 2008089636, 2008 .
   Google Scholar
• Kim , K.-R. ; Rhee , S.-D. ; Kim , H. Y. ; Jung , W. H. ; Yang , S.-D. ; Kim , S. S. ; Ahn , J. H. ; Cheon , H. G. KR-62436, 6-{2-[2-(5-cyano-4,5-dihydropyrazol-1-yl)-2-oxoethylamino]ethylamino}nicotinonitrile, is a novel dipeptidyl peptidase-IV (DPP-IV) inhibitor with anti-hyperglycemic activity . Eur. J. Pharmacol. 2005 , 518 , 63 – 70 .
   PubMed Web of Science ®Google Scholar