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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, 2010 - Issue 6
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Original Articles

Parallel Synthesis of Novel 3-Substituted 1-Ethyl-6-methylpyrimido[4,5-c]pyridazine-5,7(1H,6H)-dione Analogs

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Pages 821-832 | Received 25 Mar 2009, Published online: 22 Feb 2010

REFERENCES

  • Billings , B. K. ; Wagner , J. A. ; Cook , P. D. ; Castle , R. N. The synthesis of pyrimido[4,5-c]pyridazines and [2,3-d]pyrimidines related to toxoflavin and fervenulin . J. Heterocycl. Chem. 1975 , 12 , 1221 – 1224 .
  • For examples of using parallel synthesis in the preparation of heterocycles, see (a) Varga , L. ; Nagy , T. ; Kovesdi , I. ; Benet-Buchholz , J. ; Dorman , G. ; Urge , L. ; Darvas , F. Solution-phase parallel synthesis of 4,6-diaryl-pyrimidine-2-ylamines and 2-amino-5,5-disubstituted-3,5-dihydro-imidazol-4-ones via a rearrangement . Tetrahedron 2003 , 59 , 655 – 622 ; (b) Cavicchioli , M. ; Marat , X. ; Monteiro , N. ; Hartmann , B. ; Balme , G. Solution-phase parallel tetrahydrofuran synthesis with propargyl alcohols and benzylidene- (or alkylidene-)malonates . Tetrahedron Lett. 2002 , 43 , 2609 – 2611 .
  • (a) Yoneda , F. ; Nakagawa , K. ; Koshiro , A. ; Fujita , T. ; Harima , Y. Syntheses and properties of 4-deazatoxoflavins and related compounds . Chem. Pharm. Bull. 1982 , 30 , 172 – 179 ; (b) Yoneda , F. ; Nakagawa , K. ; Noguchi , M. ; Higuchi , M. Syntheses of 1,6-dimethylpyrimido[4,5-c]pyridazine-5,7(1H,6H)-diones (4-deazatoxoflavins) and their use in the autorecycling oxidation of alcohols and amines . Chem. Pharm. Bull. 1981 , 29 , 379 – 385 .
  • Petry , S. ; Baringhaus , K.-H. ; Tennagels , N. ; Mueller , G. Pyrimido[5,4-e][1,2,4]triazine-5,7-diones, methods for producing the same and their use. Canadian Patent 2,513,285, 2004 .

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