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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, 2010 - Issue 7
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Original Articles

Short Synthesis of COX-2 Inhibitor Inotilone

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Pages 1088-1092 | Received 03 Apr 2009, Published online: 04 Mar 2010

REFERENCES

  • Wangun , H. V. K. ; Härtl , A. ; Kiet , T. T. ; Hertweck , C. Inotilone and related phenylpropanoid polyketides from Inonotus sp. and their identification as potent COX and XO inhibitors . Org. Biomol. Chem. 2006 , 4 , 2545 – 2548 .
  • Vane , J. R. ; Bakhle , Y. S. ; Botting , R. M. Cyclooxygenases 1 and 2 . Ann. Rev. Pharmacol. Toxicol. 1998 , 38 , 97 – 120 .
  • Shamshina , J. L. ; Snowden , T. S. Convergent synthesis of potent COX-2 inhibitor inotlone . Tetrahedron Lett. 2007 , 48 , 3767 – 3769 .
  • Chimichi , S. ; Boccalini , M. ; Cosimelli , B. ; Viola , G. ; Vedaldi , D. ; Dall , F. New geiparvarin analogues from 7-(2-oxoethoxy)coumarins as efficient in vitro antitumoral agents. Tetrahedron Lett. 2002, 43, 7473–7476.
  • Chimichi , S. ; Boccalini , M. ; Cosimelli , B. ; Viola , G. ; Vedaldi , D. ; Dall , F. New 5-(2-ethenylsubstituted)-3(2H)-furanones with in vitro antiproliferative avtivity . Tetrahedron 2003 , 59 , 5215 – 5223 .

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