Impurity Profile Study of Venlafaxine Hydrochloride, an Antipsychotic Drug Substance

REFERENCES

• Yardly , J. P. ; Morris Hosbands , G. E. ; Stack , G. ; Butch , J. ; Bicksler , J. ; Moyer , J. A. ; Muth , E. A. ; Andree , T. ; Fletcher , III , H. ; James , N. G. ; Sielecki , A. R. 2-Phenyl-2-(1-hydroxycycloalkyl) ethylamine derivatives: Synthesis and antidepressant activity . J. Med. Chem. 1990 , 33 , 2899 – 2905 .
   PubMed Web of Science ®Google Scholar
• Morris Husbands , G. E. ; Yardly , J. P. ; Muth , E. A. 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl) ethylamine derivatives . US Patent 4,535,186, 1985 .
   Google Scholar
• Morris Husbands , G. E. ; Yardly , J. P. ; Muth , E. A. Substituted phenylacetonitriles . US Patent 4,611,078, 1986 .
   Google Scholar
• ICH . Guideline Q3A (R): Impurities in new drug substances. February 7, 2002 .
   Google Scholar
• Basappa ; Kavitha , C. V. ; Rangappa , K. S. Simple and an efficient method for the synthesis of 1-[2-dimethylamino-1-(4-methoxy-phenyl)-ethyl]-cyclohexanol hydrochloride: (+)-Venlafaxine racemic mixtures . Bioorg. Med. Chem. Lett. 2004 , 14 , 3279 – 3281 .
   PubMed Web of Science ®Google Scholar
• IPDO-IPM Communication No. 00096.
   Google Scholar