Three-Component, One-Pot Synthesis of New Functionalized Pyrrolines

REFERENCES

• Butler , M. S. The role of natural product chemistry in drug discovery . J. Nat. Prod. 2004 , 67 , 2141 – 2153 .
   PubMed Web of Science ®Google Scholar
• Bellina , F. ; Rossi , R. Synthesis and biological activity of pyrrole, pyrroline, and pyrrolidine derivatives with two aryl groups on adjacent positions . Tetrahedron 2006 , 62 , 7213 – 7256 .
   Web of Science ®Google Scholar
• Ruegg , U. T. ; Burgess , G. M. Staurosporine, K252 and UCN01: Potent but nonspecific inhibitors of protein kinases . Trends Pharmacol. Sci. 1989 , 10 , 218 – 220 .
   PubMed Web of Science ®Google Scholar
• Castellano , S. ; Fiji , H. D. G. ; Kinderman , S. S. ; Watanabe , M. ; de Leon , P. ; Tamanoi , F. ; Kwon , O. Small-molecule inhibitors of protein eranylgeranyltransferase type I . J. Am. Chem. Soc. 2007 , 129 , 5843 – 5845 .
   PubMed Web of Science ®Google Scholar
• Kadish , K. M. ; Smith , K. M. ; Guilard , R. (Eds.). The Porphyrin Handbook ; Academic Press : San Diego , 2003 ; vols. 11–20 .
   Google Scholar
• Pluotno , A. ; Carmeli , S. Banyasin A and banyasides A and B, three novel modified peptides from a water bloom of the cyanobacterium Nostoc sp . Tetrahedron 2005 , 61 , 575 – 583 .
   Web of Science ®Google Scholar
• Dannhardt , G. ; Kiefer , W. 1-Pyrrolines (3,4-dihydro-2H-pyrroles) as a template for new drugs . Arch. Pharm. Pharm. Med. Chem. 2001 , 334 , 183 – 188 .
   PubMed Web of Science ®Google Scholar
• Shvekhgeimer , M.-G. A. Methods for the synthesis of 3,4-2H-dihydropyrroles (Δ□-pyrrolines) and their chemical transformations . Chem. Heterocycl. Compd. 2003 , 39 , 405 – 448 .
   Google Scholar
• (a) Evdokimov , N. M. ; Magedov , I. V. ; Kireev , A. S. ; Kornienko , A. One-step, three-component synthesis of pyridines and 1,4-dihydropyridines with manifold medicinal utility . Org. Lett. 2006 , 8 , 899 – 902 ; (b) Evdokimov , N. M. ; Kireev , A. S. ; Yakovenko , A. A. ; Antipin , M. Y. ; Magedov , I. V. ; Kornienko , A. Convenient one-step synthesis of a medicinally relevant benzopyranopyridine system . Tetrahedron Lett. 2006 , 47 , 9309 – 9312 ; (c) Evdokimov , N. M. ; Kireev , A. S. ; Yakovenko , A. A. ; Antipin , M. Y. ; Magedov , I. V. ; Kornienko , A. One-step synthesis of heterocyclic privileged medicinal scaffolds by a multicomponent reaction of malononitrile with aldehydes and thiols . J. Org. Chem. 2007 , 72 , 3443 – 3453 .
   PubMed Web of Science ®Google Scholar
• Ugi , I. Isonitrile Chemistry ; Academic Press : London , 1971 .
   Google Scholar
• Walborsky , H. M. ; Periasamy , M. P. The Chemistry of Functional Groups ; S. Patai , Z. Rappoport (Eds.); Wiley : New York , 1983 ; suppl. C , p. 835 , chapter 20 .
   Google Scholar
• Domling , A. ; Ugi , I. Multicomponent reactions with isocyanides . Angew. Chem., Int. Ed. Engl. 2000 , 39 , 3168 – 3210 .
   PubMed Web of Science ®Google Scholar
• Marcaccini , S. ; Torroba , T. The use of isocyanides in heterocyclic synthesis . Org. Prep. Proced. Int. 1993 , 25 , 141 – 208 .
   Web of Science ®Google Scholar