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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, 2010 - Issue 9
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Original Articles

Expeditious One-Pot, Four-Step Preparation of 2-t-Butoxycarbonyl-6-hydroxy-1,2,3,4-tetrahydroisoquinoline and an Improved Conversion to Its 6-Cyano Derivative

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Pages 1399-1404 | Received 19 Jun 2009, Published online: 07 Apr 2010

REFERENCES

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  • For recent examples, see (a) Alper , P. ; Azimioara , M. ; Cow , C. ; Epple , R. ; Jiang , S. ; Lelais , G. ; Michellys , P.-Y. ; Nguyen , T. N. ; Westscott-Baker , L. ; Wu , B. Tetrahydroisoquinoline compounds and compositions as modulators of GPR119 activity and their preparation . WO Patent 2008097428, 2008; (b) Cowan , D. J. ; Larkin , A. L. ; Zhang , C. ; Musso , D. L. ; Green , G. M. ; Cadilla , R. ; Spearing , P. K. ; Bishop , M. J. ; Speake , J. D. Preparation of di(hetero)aryls as antagonists or inverse agonists at opioid receptors . WO Patent 2008021849, 2008; (c) Habashita , H. ; Nakade , S. ; Preparation of heterocyclic compounds having sphingosine-1-phosphate (S1P) receptor binding potency . WO Patent 2006001463, 2006; (d) Ueno , H. ; Yokota , K. ; Hoshi , J.-I. ; Yasue , K. ; Hayashi , M. ; Hase , Y. ; Uchida , I. ; Aisaka , K. ; Katoh , S. ; Cho , H. Synthesis and structure–activity relationships of novel selective factor Xa inhibitors with a retrahydroisoquinoline ring . J. Med. Chem. 2005 , 48 ( 10 ), 3586 – 3604 ; (e) Babin , D. ; Benedetti , Y. ; Chatreaux , F. ; Weston , J. B. Preparation of novel 1,2,3,4-tetrahydrosioquinolines for use as fungicides . WO Patent 2001074808 , 2001 .
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