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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 41, 2010 - Issue 1
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Original Articles

Synthesis and Characterization of Potential Impurities of Carvedilol, an Antihypertensive Drug

Somisetti Narender Rao Research and Development, Srini Pharmaceuticals Ltd., Hyderabad, India
,
Devarasetty Sitaramaiah Research and Development, Srini Pharmaceuticals Ltd., Hyderabad, India
,
Kema Srimannarayana Research and Development, Srini Pharmaceuticals Ltd., Hyderabad, India
,
Challa Nageswar Rao Research and Development, Srini Pharmaceuticals Ltd., Hyderabad, India
,
Peddi Srinivasa Rao Research and Development, Srini Pharmaceuticals Ltd., Hyderabad, India
&
K. Sudhakar Babu Department of Chemistry, Sri Krishna Devaraya University, Anantapur, IndiaCorrespondence[email protected]
Pages 85-93 | Received 05 Sep 2009, Published online: 14 Dec 2010

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  • International Conference of Harmonization (ICH). Q3A(R) Impurities in New Drug Substance , Feb . 2002 .
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  • Madhusudhan , G. ; Chinnam , K. ; Anand Kumar , B. ; Satyanarayana , R. ; Balraju , V. Synthesis of impurity A in carvedilol: A β-adrenergic receptor . Ind. J. Chem. 2009 , 48B , 741 – 745 .
  • Nemeth , N. ; Nagy , K. ; Cselenyak , J. ; Szabo , T. ; Balazs , L. ; Doman , I. ; Greff , Z. ; Nagy , P. K. ; Seres , P. Process and intermediates for preparing 1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol(carvedilol). 1-EP 918055 , Nov. 24 , 1998 .
  • European Directorate for the Quality of Medicines . European Pharmacopia 5.0; Strasbourg, France, pp. 1193 – 1194 .

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