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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 41, 2011 - Issue 3
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Original Articles

Efficient Synthesis and Practical Resolution of 1-(Naphthalen-1-yl)ethanamine, a Key Intermediate for Cinacalcet

Vijayavitthal T. Mathad Department of Process Research and Development, Megafine Pharma (P) Ltd., Nashik, Maharashtra, IndiaCorrespondence[email protected] ; [email protected]
,
Gorakshanath B. Shinde Department of Process Research and Development, Megafine Pharma (P) Ltd., Nashik, Maharashtra, India
,
Sharad S. Ippar Department of Process Research and Development, Megafine Pharma (P) Ltd., Nashik, Maharashtra, India
,
Navnath C. Niphade Department of Process Research and Development, Megafine Pharma (P) Ltd., Nashik, Maharashtra, India
,
Raghavendra K. Panchangam Department of Process Research and Development, Megafine Pharma (P) Ltd., Nashik, Maharashtra, India
&
Pravinchandra J. Vankawala Department of Process Research and Development, Megafine Pharma (P) Ltd., Nashik, Maharashtra, India
Pages 341-346 | Received 06 Sep 2009, Published online: 13 Jan 2011

REFERENCES

  • Rouhi , A. M. Chiral business . Chem. Eng. News 2003 , 81 ( 18 ), 45 .
  • (a) Hoeveten , W. ; Wynberg , H. Design of resolving agents; Chiral cyclic phosphoric acids . J. Org. Chem. 1985 , 50 , 4508 ; (b) Pallavicini , M. ; Valoti , E. ; Villa , L. ; Piccolo , O. Isopropylidene glycerol hydrogen phthalate: A new resolving agent: Application to the resolution of 1-arylethylamines . Tetrahedron: Asymmetry 1996 , 7 , 1117 .
  • Franceschini , N. ; Joy , M. S. ; Kshirsagar , A. A calcimimetic agent for the management of primary and secondary hyperparathyroidism . Expert Opin. Invest. Drugs 2003 , 12 , 1413 .
  • (a) Sorbera , L. A. ; Castaner , R. M. ; Bayes , M. Cinacalcet hydrochloride . Drugs Future 2002 , 27 , 831 – 836 ; (b) Van Wagene , B. C. ; Balandrin , M. F. ; DelMar , E. G. ; Nemeth , E. F. Calcium receptor active compounds. US Patent 6,211,244, April 3, 2001 .
  • (a) Revital , L. L. Process for the preparation of cincacalcet base. US Patent 7,449,603, November 11, 2008 ; (b) Revital , L. L. ; Eisenstadt , A. ; Wizel , S. ; Avhar-Maydan , S. ; Raizi , Y. ; Revital , R. Process for preparing cincalcet hydrochloride. US Patent 7,250,533, July 31, 2007 ; (c) Bijukumar , G. ; Biswas , M. ; Bhirud , S. B. ; Agarwal , R. Efficient synthesis of cinacalcet hydrochloride . Synth. Commun. 2008 , 38 , 1512 ; (d) Thiel , O. ; Bernard , C. ; Larsen , R. ; Martinelli , M. ; Raza , M. Methods of synthesizing cinacalcet and salts thereof. WO Patent 2009/002427, December 31, 2008 ; (e) Srinivasan , C. V. ; Johar , P. S. ; Wadhwa , L. Process for the preparation of amine derivatives as calcimimetics. WO Patent 2008/035381, March 27, 2008 .
  • Martin , J. ; Campbell , L. A. Transfer hydrogenation process. WO Patent 2001/012574 A1, February 22, 2001 .
  • International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). Section Q3B: Guidelines on Impurities in New Drug Products via Food and Drug Administration (FDA). Available at http://www.fda.gov/cder/guidance/1317fnl.pdf .
  • Blacker , A. J. ; Martin , J. Process for the preparation of aromatic amines. WO 2004/ 110976, December 23, 2004 .
  • Bottoms , R. R. Optical resolution of alpha-(α-α′′-naphthyl)ethylamine. US Patent 2, 996,545, August 15, 1961 .
  • (a) Jacques , J. ; Collet , A. ; Wilen , S. H. Enantiomers, Racemates, and Resolution ; Wiley : New York , 1981 ; p. 251 ; (b) Kozma , D. Handbook of Optical Resolution via Diastereomeric Salt Formation ; CRC Press : Boca Raton , FL , 2002 .

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