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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 43, 2013 - Issue 8
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Original Articles

Microwave-Promoted Synthesis of Some Novel 4-(4-Methyl-phenyl)-Substituted Phthalazin-1-one Derivatives

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Pages 1127-1137 | Received 25 Apr 2011, Published online: 21 Feb 2013

REFERENCES

  • Demirayak , S. ; Karaburun , A. C. ; Kayagil , I. ; Erol , K. ; Sirmagul , B. Some pyridazinone and phthalazinone derivatives and their vasodilator activities . Arch. Pharmac. 2004 , 27 , 13 .
  • Hagiwara , M. ; Endo , T.; Kanayama T. ; Hidaka , H. Effect of 1-(3-chloroanilino)-4-phenylphthalazine (MY-5445), a specific inhibitor of cyclic GMP phosphodiesterase, on human platelet aggregation . J. Pharmacol. Exp. Ther. 1984 , 228 , 467 .
  • Yamaguchi , M. ; Kamei , K. ; Koga , T. ; Akima , M. ; Kuroki , T. ; Ohi , N. Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation, 1: 2-[2-(1-Imidazolyl)alkyl]-1(2H)-phthalazinones . Chem. Pharm. Bull. 1995 , 43 ( 2 ), 332 – 334 .
  • Ueno , K. ; Moroi , R. ; Kitagawa , M. ; Asano , K. ; Miyazaki , S. Structures of reaction products from 1-hydrazino-phthalazine and some carbonyls . Chem. Pharm. Bull. 1976 , 24 , 1068 .
  • Scheffler , G. ; Engel , J. ; Kutscher , B. ; Sheldrick , W. S. ; Bell , P. Synthese und Kristallstrukturanalyse von Azelastin . Arch. Pharm. 1988 , 321 , 205 – 208 .
  • Sriram , D. ; Yogeeswari , P. ; Senthilkumar , P. ; Dewkar , S. Synthesis and antimycobacterial evaluation of novel phthalazin-4-ylacetamides against log- and starved-phase cultures . Chem. Biol. and Drug Design 2010 , 75 ( 4 ), 381 .
  • Beyer , M. A. ; Diecke , F. P. J. ; Mistry , K. ; Cruze , E. Comparison of the effects of zopolrestat and sorbinil on lens myo lnositol influx . Pharmacol. 1997 , 54 , 76 – 83 .
  • Marcaccini , S. ; Pepino , R. ; Polo , C. ; Pazo , M. C. Studies on isocyanides and related compounds; A facile synthesis of 4-phenyl-1-(2H)phthalazinone-2-alkanoic acid amides . Synthesis 2001 , 85 .
  • Saito , Y. ; Sakamoto , T. ; Kikugawa , Y. A new and convenient synthesis of 3-aryl-3-hydroxyisoindol-1-ones and their aza analogs . Synthesis 2001 , 2 , 221 .
  • Abdel-Khalik , M. M. ; Agamy , M. S. ; Elnagdi , M. H. Chemistry of 2-arylhydrazonopropanals: Novel synthesis of 1,6-dihydropyridazines and 5-heteroaryl substituted pyrazolo[1,5-a]pyrimidines and pyrazolo[3,4-b]pyridines . Synthesis 2001 , 12 , 1861 .
  • Eguchi , Y. ; Sasaki , F. ; Takashima , Y. ; Nakajima , M. ; Ishikawa , M. Studies on antiatherosclerotic agents: Synthesis of 7-ethoxycarbonyl-4-formyl-6,8-dimethyl-1(2H)-phthalazinone derivatives and related compounds . Chem. Pharm. Bull. 1991 , 39 , 795 .
  • (a) Loupy , A. Microwaves in Organic Synthesis ; Wiley-VCH : Weinheim , 2002; (b) Kappe , C. O. Controlled microwave heating in modern organic synthesis. Angew. Chem. Int. Ed. 2004, 43, 6250; (c) Xu , Y. ; Guo , Q.-X. ; Synthesis of heterocyclic compounds under microwave irradiation. Heterocycles 2004, 63, 903; (d) Kappe , C. O. ; Dallinger , D. The impact of microwave synthesis on drug discovery. Nature Rev. Drug Dis. 2006, 5, 51.
  • Hayes , B. L. Microwave Synthesis: Chemistry at the Speed of Light . CEM Corp.: Matthews, NC , 2002 , p. 29 .
  • Nuchter , M. ; Muller , U. ; Ondruschka , B. Microwave-assisted chemical reactions . Chem. Eng. Technol. 2003 , 26 ( 12 ), 1207 – 1216 .
  • Chen , J. J. ; Deshpande , S. V. Rapid synthesis of α-ketomides using microwave irradiation–simultaneous cooling method . Tetrahedron Lett. 2003 , 44 , 8873 – 8876 .
  • Lenke , D. ; Scheffler , G. ; Brock , N. ; Vogelsang , D. Basically substituted benzyl phthalazone derivatives, acid salts there of, and process for the production. U.S. patent 3813384, 1974 .

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