A Concise Synthesis of 3,5-Dicyano-6-trifluoromethylpyridine and Preparation of a Mono Thioamide

REFERENCES

• Dicks , J. W. ; Slater , J. W. ; Bewick , D. W. PP-005–The R-enantiomer of fluazifop-butyl . In Proceedings–British Crop Protection Conference–Weeds ; British Crop Protection Council: Surrey, UK, 1985; Vol. 1, 271–280 .
   Google Scholar
• Michel , A. Bicyclopyrone: The new active ingredient for weed control in sugar cane and corn. J. Pest. Sci. 2011 , 36 ( 1 ), 164.
   Web of Science ®Google Scholar
• Roques , J.-F. ; Sylvestre , M. Fluazinam: An antimildew fungicide for potatoes . Phytoma 1994 , 460 , 48 – 50 .
   Google Scholar
• Morita , M. ; Ueda , T. ; Yoneda , T. ; Koyanagi , T. ; Murai , S. ; Matsuo , N. ; Stratmann , B. ; Ruelens , P. IKI-220: A novel systemic aphicide. In Proceedings–British Crop Protection Conference–Pests and Diseases; British Crop Protection Council: Surrey, UK, 2000; Vol. 1, 59–65.
   Google Scholar
• Swallow, S. Fluorine-containing pharmaceuticals. In Fluorine in Pharmaceutical and Medicinal Chemistry: From Biophysical Aspects to Clinical Applications ; V. Gouverneur and K. Müller , Eds.; Imperial College Press: London, 2012; 141–174.
   Google Scholar
• Fleming , F. F. ; Yao , L. ; Ravikumar , P. C. ; Funk , L. ; Shook , B. C. Nitrile-containing pharmaceuticals: Efficacious roles of the nitrile pharmacophore . J. Med. Chem. 2010 , 53 ( 22 ), 7902 – 7917.
   PubMed Web of Science ®Google Scholar
• Cooke , J. W. B. ; Coleman , M. J. ; Caine , D. M. ; Jenkins , K. P . Efficient synthesis of 2-trihalomethyl-5-cyanopyridines . Tetrahedron Lett. 1998 , 39 , 7965 – 7966 .
   Web of Science ®Google Scholar
• Scotti , F. ; Frazza , E. J. The synthesis and reactions of beta-chloroacrylonitrile . J. Org. Chem. 1964 , 29 ( 7 ), 1800 – 1808.
   Web of Science ®Google Scholar
• Bayer. Process for the preparation of a mixture of aminomethylenated glutaconitriles. Patent EP 0 607 802 B1, 1998.
   Google Scholar
• Hojo , M. ; Ryochi , M. ; Etsuji , O. Electrophilic substitutions of olefinic hydrogens: Acylation of 1,1-bis(alkylthio)-1,3-alkadienes and trans-N-acetyl-N-isopropyl-1-amino-1,3-butadiene . Tetrahedron Lett. 1986 , 27 , 353 – 356 .
   Web of Science ®Google Scholar