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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 50, 2020 - Issue 13
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SYNTHETIC COMMUNICATIONS REVIEWS

Synthesis and antioxidant screening of new 2-cyano-3-(1,3-diphenyl-1H-pyrazol-4-yl)acryloyl amide derivatives and some pyrazole-based heterocycles

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Pages 2066-2077 | Received 02 Mar 2020, Published online: 18 May 2020

References

  • Halim, K. N. M.; Ramadan, S. K.; Rizk, S. A.; El-Hashash, M. A. Synthesis, DFT Study, Molecular Docking and Insecticidal Evaluation of Some Pyrazole-Based Tetrahydropyrimidine Derivatives. Synth. Commun. 2020, 50, 1159 . DOI: 10.1080/00397911.2020.1720739.
  • Morsy, A. R. I.; Ramadan, S. K.; Elsafty, M. M. Synthesis and Antiviral Activity of Some Pyrrolonyl Substituted Heterocycles as Additives to Enhance Inactivated Newcastle Disease Vaccine. Med. Chem. Res. 2020, (in press). DOI: 10.1007/s00044-020-02538-z.
  • Ramadan, S. K.; Abou-Elmagd, W. S. I. Synthesis and Anti H5N1 Activities of Some Novel Fused Heterocycles Bearing Pyrazolyl Moiety. Synth. Commun. 2018, 48, 2409–2419. DOI: 10.1080/00397911.2018.1491995.
  • Karrouchi, K.; Radi, S.; Ramli, Y.; Taoufik, J.; Mabkhot, Y. N.; Al-Aizari, F. A.; Ansar, M. Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review. Molecules 2018, 23, 134. DOI: 10.3390/molecules23010134.
  • Rashad, A. E.; Hegab, M. I.; Abdel-Megeid, R. E.; Micky, J. A.; Abdel-Megeid, F. M. Synthesis and Antiviral Evaluation of Some New Pyrazole and Fused Pyrazolopyrimidine Derivatives. Bioorg. Med. Chem. 2008, 16, 7102–7106. DOI: 10.1016/j.bmc.2008.06.054.
  • Ramadan, S. K.; Shaban, S. S.; Hashem, A. I. Facile and Expedient Synthesis and Anti-Proliferative Activity of Diversely Pyrrolones Bearing 1, 3-Diphenylpyrazole Moiety. Synth. Commun. 2020, 50, 185–196. DOI: 10.1080/00397911.2019.1691737.
  • Ramadan, S. K.; Sallam, H. A. Synthesis, Spectral Characterization, Cytotoxic, and Antimicrobial Activities of Some Novel Heterocycles Utilizing 1, 3-Diphenylpyrazole-4-Carboxaldehyde Thiosemicarbazone. J. Heterocyclic Chem. 2018, 55, 1942–1954. DOI: 10.1002/jhet.3232.
  • Ansari, A.; Ali, A.; Asif, M.; Shamsuzzaman, S. Review: Biologically Active Pyrazole Derivatives. New J. Chem. 2017, 41, 16–41. DOI: 10.1039/C6NJ03181A.
  • Ramadan, S. K.; Halim, K. N. M.; Rizk, S. A.; El-Hashash, M. A. Cytotoxic Activity and Density Functional Theory Studies of Some 1,3-Diphenylpyrazolyltetrahydropyrimidine Derivatives. J. Iran. Chem. Soc. 2020, (in press). DOI: 10.1007/s13738-020-01880-8.
  • El-Helw, E. A. E.; El-Badawy, A. A. Synthesis of Chromenone, Pyrimidinone, Thiazoline, and Quinolone Derivatives as Prospective Antitumor Agents. J. Heterocyclic Chem. 2020, (in press). DOI: 10.1002/jhet.3948.
  • Ramadan, S. K.; Abou-Elmagd, W. S. I.; El-Ziaty, A. K.; Elzahar, M. I.; Hashem, A. I. Synthesis and Antitumor Activity Evaluation of Some N-Heterocycles Derived from Pyrazolyl-Substituted 2(3H)-Furanone. Synth. Commun. 2016, 46, 1197–1208. DOI: 10.1080/00397911.2016.1193755.
  • El-Helw, E. A.; Derbala, H. A.; El-Shahawi, M. M.; Salem, M. S.; Ali, M. M. Synthesis and In Vitro Antitumor Activity of Novel Chromenones Bearing Benzothiazole Moiety. Russ. J. Bioorg. Chem. 2019, 45, 42. DOI: 10.1134/S1068162019010047.
  • Ramadan, S. K.; El-Helw, E. A. E. Synthesis and Antimicrobial Activity Evaluation of Some Novel Heterocycles Derived from Chromonyl-2(3H)-Furanone. J. Chem. Res. 2018, 42, 332–336. DOI: 10.3184/174751918X15295796734379.
  • Padmaja, A.; Payani, T.; Dinneswara Reddy, G.; Padmavathi, V. Synthesis, Antimicrobial and Antioxidant Activities of Substituted Pyrazoles, Isoxazoles, Pyrimidine and Thioxopyrimidine Derivatives. Eur. J. Med. Chem. 2009, 44, 4557–4566. DOI: 10.1016/j.ejmech.2009.06.024.
  • Ramadan, S. K.; El-Helw, E. A. E.; Sallam, H. A. Cytotoxic and Antimicrobial Activities of Some Novel Heterocycles Employing 6-(1,3-Diphenyl-1H-Pyrazol-4-yl)-4-Oxo-2-Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carbonitrile. Heterocycl. Commun. 2019, 25, 107–115. DOI: 10.1515/hc-2019-0008.
  • El-Helw, E. A. E.; Sallam, H. A.; Elgubbi, A. S. Antioxidant Activity of Some N-Heterocycles Derived from 2-(1-(2-Oxo-2H-Chromen-3-yl)Ethylidene) Hydrazinecarbothioamide. Synth. Commun. 2019, 49, 2651–2661. DOI: 10.1080/00397911.2019.1638938.
  • Shiba, S. A.; Madkour, H. M. F.; Hamed, A. A.; Sayed, H. M.; El‐aziz Hashash, M. A. Utility of 2-Cyano-3-Phenyl-2-Propenoyl Chloride as Michael’s Acceptor in Heterocyclic Synthesis with Mono- and Bi-Dentate Nucleophiles. Eur. J. Chem. 2011, 2, 200–205. DOI: 10.5155/eurjchem.2.2.200-205.365.
  • Shiba, S. A.; El-Ziaty, A. K.; El-Aasar, N. K.; Al-Saman, H. A. Synthesis of New 2-Propenoylamides and 3-H-Quinazolin-4-One Derivatives. Org. Chem. Indian J. 2012, 8, 135. http://research.asu.edu.eg/handle/123456789/168225.
  • El-Ziaty, A. K.; Abdalh, A.; Hamed, A. A.; Shiba, S. A.; Abdullha, A. Synthesis of Novel 2-Propenoylamides, Esters, Heterocyclic Compounds and Their Screening as Antifungal and Antibacterial Agents. Eur. J. Chem. 2012, 3, 65–70. DOI: 10.5155/eurjchem.3.1.65-70.518.
  • El-Ziaty, A. K.; Shiba, S. A. Antibacterial Activities of New (E) 2-Cyano-3-(3′,4′-Dimethoxyphenyl)-2-Propenoylamide Derivatives. Synth. Commun. 2007, 37, 4043–4057. DOI: 10.1080/00397910701575491.
  • El-Helw, E. A. E.; Gado, M. M.; El-Ziaty, A. K. Synthesis and Anti-Rotavirus Activity of Some Nitrogen Heterocycles Integrated with Pyrazole Scaffold. J. Iran. Chem. Soc. 2020, 17, 1479 . DOI: 10.1007/s13738-020-01873-7.
  • Lissi, E. A.; Modak, B.; Torres, R.; Escobar, J.; Urzua, A. Free-Radical Scavenging Properties and Reducing Power of Grape Cane Extracts from 11 Selected Grape Cultivars Widely Grown in China. Free Radic. Res. 1999, 30, 471–477. DOI: 10.1080/10715769900300511.
  • Kenchappa, R.; Bodke, Y. D.; Chandrashekar, A.; Sindhe, M. A.; Peethambar, S. K. Synthesis of Coumarin Derivatives Containing Pyrazole and Indenone Rings as Potent Antioxidant and Antihyperglycemic Agents. Arabian J. Chem. 2017, 10, S3895–S3906. DOI: 10.1016/j.arabjc.2014.05.029.
  • Gouhar, R. S.; Abou-Elmagd, W. S. I.; El-Zahar, M. I.; Kamel, M. M.; El-Ghonamy, D. H. Synthesis of Novel 5,6,7,8,9,10-Hexahydropyrimido[4,5-b]Quinoline Derivatives for Antimicrobial and Antioxidant Evaluation. Res. Chem. Intermed. 2017, 43, 1301–1327. DOI: 10.1007/s11164-016-2699-0.

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