References
- Wang, S.; Yuan, X.-H.; Wang, S.-Q.; Zhao, W.; Chen, X.-B.; Yu, B. FDA-Approved Pyrimidine-Fused Bicyclic Heterocycles for Cancer Therapy: Synthesis and Clinical Application. Eur. J. Med. Chem. 2021, 214, 113218. DOI: https://doi.org/10.1016/j.ejmech.2021.113218.
- Zarenezhad, E.; Farjam, M.; Iraji, A. Synthesis and Biological Activity of Pyrimidines-Containing Hybrids: Focusing on Pharmacological Application. J. Mol. Struct. 2021, 1230, 129833. DOI: https://doi.org/10.1016/j.molstruc.2020.129833.
- Berdiyorov, G. R.; Hamoudi, H. Electronic Transport through Molecules Containing Pyrimidine Units: First-Principles Calculations. J. Comput. Sci. 2021, 48, 101261. DOI: https://doi.org/10.1016/j.jocs.2020.101261.
- Maddila, S.; Nagaraju, K.; Jonnalagadda, S. B. Synthesis and Antimicrobial Evaluation of Novel Pyrano[2,3-d]-Pyrimidine Bearing 1,2,3-Triazoles. Chem. Data Collect. 2020, 28, 100486. DOI: https://doi.org/10.1016/j.cdc.2020.100486.
- Bhat, A. R.; Dongre, R. S.; Almalki, F. A.; Berredjem, M.; Aissaoui, M.; Touzani, R.; Hadda, T. B.; Akhter, M. S. Synthesis, Biological Activity and POM/DFT/Docking Analyses of Annulated Pyrano[2,3-d]Pyrimidine Derivatives: Identification of Antibacterial and Antitumor Pharmacophore Sites. Bioorg. Chem. 2021, 106, 104480. DOI: https://doi.org/10.1016/j.bioorg.2020.104480.
- Gorlitzer, K.; Herbig, S.; Walter, R. D. Indeno[1,2-d]Pyrimidin-4-yl-Amines. Pharmazie. 1997, 52, 670–672.
- Fujiwara, N.; Nakajima, T.; Ueda, Y.; Fujita, H. K.; Kawakami, H. Novel Piperidinylpyrimidine Derivatives as Inhibitors of HIV-1 LTR Activation. Bioorg. Med. Chem. 2008, 16, 9804–9816. DOI: https://doi.org/10.1016/j.bmc.2008.09.059.
- Naik, N. S.; Shastri, L. A.; Chougala, B. M.; Samundeeswari, S.; Holiyachi, M.; Joshi, S. D.; Sunagar, V. Synthesis of Novel Aryl and Coumarin Substituted Pyrazolo[1,5-a]Pyrimidine Derivatives as Potent anti-Inflammatory and Anticancer Agents. Chem. Data Collect. 2020, 30, 100550. DOI: https://doi.org/10.1016/j.cdc.2020.100550.
- Alfayomy, A. M.; Abdel-Aziz, S. A.; Marzouk, A. A.; Shaykoon, M. A.; Narumi, A.; Konno, H.; Abou-Seri, S. M.; Ragab, F. A. F. Design and Synthesis of Pyrimidine-5-Carbonitrile Hybrids as COX-2 Inhibitors: Anti-Inflammatory Activity, Ulcerogenic Liability, Histopathological and Docking Studies. Bioorg. Chem. 2021, 108, 104555. DOI: https://doi.org/10.1016/j.bioorg.2020.104555.
- Unnisa, A.; Abouzied, A. S.; Baratam, A.; Lakshmi, K. N. V. C.; Hussain, T.; Kunduru, R. D.; Banu, H.; Fatima, S. B.; Hussian, A.; Selvarajan, K. K. Design, Synthesis, Characterization, Computational Study and In-Vitro Antioxidant and Antiinflammatory Activities of Few Novel 6-Aryl Substituted Pyrimidine Azo Dyes. Arab. J. Chem. 2020, 13, 8638–8649. DOI: https://doi.org/10.1016/j.arabjc.2020.09.050.
- Goffin, E.; Jacques, N.; Musumeci, L.; Nchimi, A.; Oury, C.; Lancellotti, P.; Pirotte, B. Synthesis of Ticagrelor Analogues Belonging to 1,2,3-Triazolo[4,5-d] Pyrimidines and Study of Their Antiplatelet and Antibacterial Activity. Eur. J. Med. Chem. 2020, 208, 112767. DOI: https://doi.org/10.1016/j.ejmech.2020.112767.
- Ranjan Dwivedi, A.; Kumar, V.; Kaur, H.; Kumar, N.; Prakash Yadav, R.; Poduri, R.; Baranwal, S.; Kumar, V. Anti-Proliferative Potential of Triphenyl Substituted Pyrimidines against MDA-MB-231, HCT-116 and HT-29 Cancer Cell Lines. Bioorg. Med. Chem. Lett. 2020, 30, 127468. DOI: https://doi.org/10.1016/j.bmcl.2020.127468.
- Esteban-Parra, G. M.; Sebastián, E. S.; Cepeda, J.; Sánchez-González, C.; Rivas-García, L.; Llopis, J.; Aranda, P.; Sánchez-Moreno, M.; Quirós, M.; Rodríguez-Diéguez, A. Anti-Diabetic and anti-Parasitic Properties of a Family of Luminescent Zinc Coordination Compounds Based on the 7-Amino-5-Methyl-1,2,4-Triazolo[1,5- a]Pyrimidine Ligand. J. Inorg. Biochem. 2020, 212, 111235. DOI: https://doi.org/10.1016/j.jinorgbio.2020.111235.
- Ashok, N.; Madhukar, J.; Sridhar, G. Design, Synthesis and Biological Evaluation of 1,2,4-Oxadiazole Linked 1,2,4-Thiadiazole-Pyrimidines as Anticancer Agents. Chem. Data Collect. 2021, 32, 100653. DOI: https://doi.org/10.1016/j.cdc.2021.100653.
- Kilic-Kurt, Z.; Ozmen, N.; Bakar-Ates, F. Synthesis and Anticancer Activity of Some Pyrimidine Derivatives with Aryl Urea Moieties as Apoptosis-Inducing Agents. Bioorg. Chem. 2020, 101, 104028. DOI: https://doi.org/10.1016/j.bioorg.2020.104028.
- Xiang, W.; Quadery, T. M.; Hamel, E.; Luckett-Chastain, L. R.; Ihnat, M. A.; Mooberry, S. L.; Gangjee, A. The 3-D Conformational Shape of N-Naphthyl-Cyclopenta[d]Pyrimidines Affects Their Potency as Microtubule Targeting Agents and Their Antitumor Activity. Bioorg. Med. Chem. 2021, 29, 115887. DOI: https://doi.org/10.1016/j.bmc.2020.115887.
- Luo, G.; Ma, Y.; Liang, X.; Xie, G.; Luo, Y.; Zha, D.; Wang, S.; Yu, L.; Zheng, X.; Wu, W.; Zhang, C. Design, Synthesis and Antitumor Evaluation of Novel 5-Methylpyrazolo[1,5-a]Pyrimidine Derivatives as Potential c-Met Inhibitors. Bioorg. Chem. 2020, 104, 104356. DOI: https://doi.org/10.1016/j.bioorg.2020.104356.
- Manzoor, S.; Prajapati, S. K.; Majumdar, S.; Raza, M. K.; Gabr, M. T.; Kumar, S.; Pal, K.; Rashid, H.; Kumar, S.; Krishnamurthy, S.; Hoda, N. Discovery of New Phenyl Sulfonyl-Pyrimidine Carboxylate Derivatives as the Potential Multi-Target Drugs with Effective anti-Alzheimer’s Action: Design, Synthesis, Crystal Structure and in-Vitro Biological Evaluation. Eur. J. Med. Chem. 2021, 215, 113224. DOI: https://doi.org/10.1016/j.ejmech.2021.113224.
- Sana, S.; Reddy, V. G.; Reddy, T. S.; Tokala, R.; Kumar, R.; Bhargava, S. K.; Shankaraiah, N. Cinnamide Derived Pyrimidine-Benzimidazole Hybrids as Tubulin Inhibitors: Synthesis, in Silico and Cell Growth Inhibition Studies. Bioorg. Chem. 2021, 110, 104765. DOI: https://doi.org/10.1016/j.bioorg.2021.104765.
- Jindal, G.; Kaur, N. Biologically Significant Pyrimidine Appended Optical Sensors: An Inclusive Anthology of Literature from 2005 to 2020. Coord. Chem. Rev. 2021, 435, 213798. DOI: https://doi.org/10.1016/j.ccr.2021.213798.
- Feckov, M.; Le Poul, P.; Bures, F.; Le Guen, F. R.; Achelle, S. Nonlinear Optical Properties of Pyrimidine Chromophores. Dyes Pigm. 2020, 182, 108659. DOI: https://doi.org/10.1016/j.dyepig.2020.108659.
- Hou, B. S.; Zhang, Q. H.; Li, Y. Y.; Zhu, G. Y.; Lei, Y.; Wang, X.; Liu, H. F.; Zhang, G. A. In-Depth Insight into the Inhibition Mechanism of Pyrimidine Derivatives on the Corrosion of Carbon Steel in CO2-Containing Environment Based on Experiments and Theoretical Calculations. Corros. Sci. 2021, 181, 109236. DOI: https://doi.org/10.1016/j.corsci.2021.109236.
- Kumar, C. B. P.; Mohana, K. N.; Raghu, M. S.; Jagadeesha, M. B.; Prashanthd, M. K.; Lokanath, N. K.; Mahesha . Fluorine Substituted Thiomethyl Pyrimidine Derivatives as Efficient Inhibitors for Mild Steel Corrosion in Hydrochloric Acid Solution: Thermodynamic, Electrochemical and DFT Studies. J. Mol. Liquids. 2020, 311, 113311. DOI: https://doi.org/10.1016/j.molliq.2020.113311.
- Monier, M.; Abdel-Latif, D.; El-Mekabaty, A.; Elattar, K. M. Bicyclic 6 + 6 Systems: advances in the Chemistry of Heterocyclic Compounds Incorporated Pyrimido[1,2-a]Pyrimidine Skeleton. MROC. 2020, 17, 717–739. DOI: https://doi.org/10.2174/1389557519666190925161145.
- Shaabani, A.; Seyyedhamzeh, M.; Maleki, A.; Hajishaabanha, F. Diketene as an Alternative Substrate for a New Biginelli-like Multicomponent Reaction: one-Pot Synthesis of 5-Carboxamide Substituted 3, 4-Dihydropyrimidine-2(1H)-Ones. Tetrahedron 2010, 66, 4040–4042. . DOI: https://doi.org/10.1016/j.tet.2010.04.028.
- Jin, T. S.; Wang, H. X.; Xing, C. Y.; Li, X. L.; Li, T. S. An Efficient One-Pot Synthesis of 3, 4-Dihydropyrimidin-2-Ones Catalyzed by Methanesulfonic Acid. Synth. Commun. 2004, 34, 3009–3016. DOI: https://doi.org/10.1081/SCC-200026660.
- Kappe, C. O. 100 Years of the Biginelli Dihydropyrimidine Synthesis. Tetrahedron. 1993, 49, 6937–6963. DOI: https://doi.org/10.1016/S0040-4020(01)87971-0.
- Ibrahim, M. A.; Hassanin, M. H.; Gabr, Y. A.; Alnamer, Y. A. Synthesis, Characterization, and Antimicrobial Evaluation of Some Novel 4-Hydroxyquinolin-2(1H)-Ones. Synth. Commun. 2014, 44, 3470–3482. . DOI: https://doi.org/10.1080/00397911.2014.949775.
- Ali, T. E.; Assiri, M. A.; Ibrahim, M. A.; Yahia, I. S. Nucleophilic Reactivity of a Novel 3-Chloro-3-(4,9-Dimethoxy-5-Oxo-5H-Furo[3,2-g]Chromen-6-yl)Prop-2-Enal. Russ. J. Org. Chem. 2020, 56, 845–855. . DOI: https://doi.org/10.1134/S1070428020050188.
- Mahdy, E. L.; Farouk, K. M. O. Easy Preparation, Characterization and Reactions of New 8‐Chloro‐7‐Formyl‐4‐Oxo‐2‐Phenyl‐4H‐Pyrimido[1,2‐a]Pyrimidine‐3‐ Carbonitrile. J. Heterocyclic Chem. 2021, 58, 1070–1078. . DOI: https://doi.org/10.1002/jhet.4237.
- Mitra, A. K.; De, A.; Karchaudhuri, N. Solvent-Free Microwave Enhanced Knoevenagel Condensation of Ethyl Cyanoacetate with Aldehydes. Synth. Commun. 1999, 29, 2731–2739. . DOI: https://doi.org/10.1080/00397919908086438.
- Deshmukh, M. B.; Salunkhe, S. M.; Patil, D. R.; Anbhule, P. V. A Novel and Efficient One Step Synthesis of 2-Amino-5-Cyano-6-Hydroxy-4-Arylpyrimidines and Their anti-Bacterial Activity. Eur. J. Med. Chem. 2009, 44, 2651–2654. DOI: https://doi.org/10.1016/j.ejmech.2008.10.018.
- Ried, W.; Meyer, A. Über Die Verwendung Von Cyanacethydrazid Zur Darstellung Von Stickstoff Heterocyclen. I. Eine Einfache Synthese Von N-Amino-α-Pyridonen. Chem. Ber. 1957, 90, 2841–2848. DOI: https://doi.org/10.1002/cber.19570901218.
- Jones, G. O.; Guner, V. A.; Houk, K. N. Synthesen Stickstoffhaltiger Heterocyclen, XXVII.† Über 1.2.4‐Triazine, I Darstellung Einiger Neuer s‐Triazolo[3.2‐c]‐as‐Triazine. J. Phys. Chem. A 2006, 110, 1216–2178. DOI: https://doi.org/10.1021/jp052055z.
- Al-Shaalan, N. H. Synthesis, Characterization and Biological Activities of Cu(II), Co(II), Mn(II), Fe(II), and UO2(VI) Complexes with a New Schiff Base Hydrazone: O-Hydroxyacetophenone-7-Chloro-4-Quinoline Hydrazone. Molecules. 2011, 16, 8629–8645. DOI: https://doi.org/10.3390/molecules16108629.
- Laakso, P. V.; Robinson, R.; Vandrewala, H. P. Studies in the Triazine Series Including a New Synthesis of 1,2,4-Triazines. Tetrahedron. 1957, 1, 103–118. DOI: https://doi.org/10.1016/0040-4020(57)85014-5.
- Gould, J. C.; Bowie, J. M. The Determination of Bacterial Sensitivity to Antibiotics. Edinb. Med. J. 1952, 59, 178–199.