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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 52, 2022 - Issue 18
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Articles

Design, synthesis, biological evaluation, and molecular docking of novel quinazolinone EGFR inhibitors as targeted anticancer agents

Zinab M. Nofala The Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Institute, National Research Center, Giza, Egypt
,
Kamelia M. Aminb Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt
,
Hanaa S. Mohameda The Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Institute, National Research Center, Giza, EgyptORCID Iconhttps://orcid.org/0000-0003-0630-8682
ORCID Icon,
Ahmed M. El-Kerdawyb Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt
,
Magdy S. Alyc Genetics Branch, Zoology Department, Faculty of Science, Beni-Suef University, Beni Suef, Egypt
,
Basma S. Habiba The Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Institute, National Research Center, Giza, Egypt
&
Alaadin E. Sarhana The Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Institute, National Research Center, Giza, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-5919-6536
ORCID Icon show all
Pages 1805-1824 | Received 28 Mar 2022, Published online: 24 Aug 2022

References

  • Bukowski, K.; Kciuk, M.; Kontek, R. Mechanisms of Multidrug Resistance in Cancer Chemotherapy. Int. J. Mol. Sci. 2020, 21, 3233. DOI: 10.3390/ijms21093233.
  • Khazir, J.; Mir, B. A.; Pandita, M.; Pilcher, L.; Riley, D.; Chashoo, G. Design and Synthesis of Sulphonyl Acetamide Analogues of Quinazoline as Anticancer Agents. Med. Chem. Res. 2020, 29, 916–925. DOI: 10.1007/s00044-020-02533-4.
  • Prenzel, N.; Fischer, O. M.; Streit, S.; Hart, S.; Ullrich, A. The Epidermal Growth Factor Receptor Family as a Central Element for Cellular Signal Transduction and Diversification. Endocr. Relat. Cancer 2001, 8, 11–31. DOI: 10.1677/erc.0.0080011.
  • Ahmad, I. An Insight into the Therapeutic Potential of Quinazoline Derivatives as Anticancer Agents. Med. Chem. Commun. 2017, 8, 871–885. DOI: 10.1039/c7md00097a.
  • Riham, F.,G.; Manal, K.; El-Ansary, D. Y.; El Kerdawy, A. M. Some 1,3,5-Trisubstituted Pyrazoline Derivatives Targeting Breast Cancer: Design, Synthesis, Cytotoxic Activity, EGFR Inhibition and Molecular Docking. Bioorg. Chem. 2020, 99, 103780. DOI: 10.1016/j.bioorg.2020.103780.
  • Ramu, G. Bioorg. Med. Chem. Lett. 2017, 27, 4741–4748. DOI: 10.1016/j.bmcl.2017.08.064.
  • Malinowski, Z.; Fornal, E.; Nowak, M.; Kontek, R.; Gajek, G.; Borek, B. Synthesis and Biological Evaluation of Some Amino- and Sulfanyl-3H-Quinazolin-4-One Derivatives as Potential Anticancer Agents. Monatsh. Chem. 2015, 146, 1723–1731. DOI: 10.1007/s00706-015-1508-6.
  • Ioannis, K. K.; Abdelhakim, E.; Elisabeth, S.; Mauro, I.; Thierry, B. Tetrahedron Lett. 2007, 48, 6609–6613. DOI: 10.1016/j.tetlet.2007.07.114.
  • Kshirsagar, U. A.; Mhaske, S. B.; Argade, N. P. Hexamethyldisilazane-Iodine Induced Intramolecular Dehydrative Cyclization of Diamides: A General Access to Natural and Unnatural Quinazolinones. Tetrahedron Lett. 2007, 48, 3243–3246. DOI: 10.1016/j.tetlet.2007.03.032.
  • Aggarwal, S.; Sinha, D.; Tiwari, A. K.; Pooja, P.; Kaul, A.; Singh, G.; Mishra, A. K. Studies for Development of Novel Quinazolinones: New Biomarker for EGFR. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2015, 143, 309–318. DOI: 10.1016/j.saa.2015.01.069.
  • Patel, H. M.; Pawara, R.; Ansari, A.; Noolvi, M.; Surana, S. Design and Synthesis of Quinazolinones as EGFR Inhibitors to Overcome EGFR Resistance Obstacle. Bioorg. Med. Chem. 2017, 25, 2713–2723. DOI: 10.1016/j.bmc.2017.03.039.
  • Aziz, M. W.; Kamal, A. M.; Mohamed, K. O.; Elgendy, A. A. Design, Synthesis and Assessment of New Series of Quinazolinone Derivatives as EGFR Inhibitors along with Their Cytotoxic Evaluation against MCF7 and A549 Cancer Cell Lines. Bioorg. Med. Chem. Lett. 2021, 41, 127987. DOI: 10.1016/j.bmcl.2021.127987.
  • Bogert, M. T.; Gortner, R. A.; Amend, C. G. Researches on Quinazolines (Twenty-Seventh Paper). the Synthesis of 3-Aminoaryl-4-Quinazolones from Acylanthranils and Aromatic Diamines. J. Am. Chem. Soc. 1911, 33, 949–962. DOI: 10.1021/ja02219a016.
  • Hatem, M. G.; Mark, C. B.; Zeinab, A. M.; Sobhi, M. G. RSC Adv. 2017, 7, 14562–14610. DOI: 10.1039/C7RA00683G.

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