References
- This study was supported by the National Institutes of Health;
- Department of Chemistry, McGill University, Montreal, Canada
- Liwshitz , Y. , Zilkha , A. and Shahak , I. 1965 . J. Org. Chem. , 21 : 1530
- 1941 . Org. Syntheses 21 Coll. Vol. 1
- 1943 . ibid. Coll. Vol. 2
- 1955 . ibid. 813 Coll. Vol 3
- Fu , S.-C. J. , Reiner , M. and Loo , T. L. 1965 . J. Org. Chem. , : 1277
- Kaneko , T. , Lee , Y. K. and Hanafusa , T. 1962 . Bull Chem. Soc. Japan , 35 : 875
- Jorgensen , E. C. and Reid , J. A. W. 1965 . J. Med. Chem. , 8 : 533
- Plant , G. W. E. 1965 . ibid. , 8 : 554
- Murray , A. III and Williams , D. L. 1958 . Organic Syntheses with Isotopes 196 New York, N. Y. : Interscience Publishers, Inc. .
- Greenstein , J. P. and Winitz , M. 1961 . Chemistry of the Amino Acids Vol. 3 , New York, N. Y. : John Wiley and Sons, Inc. .
- This procedure is very convenient and relatively inexpensive for fully deuterated amino acids since only D2O is required
- Glycine hydrochloride (1.0 mole) was quantitatively converted to glycine (negative Beilstein)
- Microanalyses were performed by Micro-Tech Laboratories, Skokie, Illinois. Amino acid hydrohalides were prepared by the method of Liwshitz, et al. (ref. 2), or purchased from Mann Research Laboratories, Inc., New York, N. Y. except 3-methyl aspartate-HCl which was made by a standard esterification procedure
- 650 A related procedure (ref. 4, p.) for this conversion affords amino acids but in lower yield and purity