A Convenient and Effective Preparation of Amino Acids from their Hydrohalide Salts

References

• This study was supported by the National Institutes of Health;
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• Department of Chemistry, McGill University, Montreal, Canada
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• This procedure is very convenient and relatively inexpensive for fully deuterated amino acids since only D2O is required
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• Glycine hydrochloride (1.0 mole) was quantitatively converted to glycine (negative Beilstein)
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• Microanalyses were performed by Micro-Tech Laboratories, Skokie, Illinois. Amino acid hydrohalides were prepared by the method of Liwshitz, et al. (ref. 2), or purchased from Mann Research Laboratories, Inc., New York, N. Y. except 3-methyl aspartate-HCl which was made by a standard esterification procedure
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• 650 A related procedure (ref. 4, p.) for this conversion affords amino acids but in lower yield and purity
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