Reduction and Reductive Alkylation of α-tert-Butylthio Carbonyl Compounds. An Efficient Method for Stepwise α-Alkylation of Esters, Nitriles and Ketones Via the α-Tert-Butylthio Derivatives

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• “ n ” . In t Use of lithium-naphthalene/THF was also commonly applicable to the substituted ketones 3d and the esters 3b. However, an intramolecular migration of t-butyl-thio group to the ester function was observed in the latter case. Thus, on alkylation with methyl iodide, 3a (R1 = R2 = n-Am) gave-butyl l-methyl, l-amyl thioheptanoate
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