Isomerization of Estragole to Anethole

References

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• In our hands a 56% converion of II to a 82:18 ratio of I:cis-isomer is obtained after 12 hr at 200°
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• To assure that isomerization does not proceed at GLC injection port temperatures with catalyst residue, this ratio was corroborated by NMR in several experiments
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• Similar treatment of I affords an 95:4:1 ratio of I:cis-I:II
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• The active catalyst may be clustered; for simplicity a mononuclear species is presented
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• Use of anethole as a fragrance or flavor requires <1% contamination with the cis-isomer due to toxicity and sharp taste of the latter
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