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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 12, 1982 - Issue 13
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Original Articles

On the Alkylation of 5-Fluorouracil-Some Recent Findings

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Pages 1047-1054 | Published online: 06 Dec 2006

References

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  • Kametani , T. , Kigasawa , K. , Hiiragi , M. , Wakisaka , K. , Haga , S. , Nagamatsu , Y. , Sugi , H. , Fukawa , K. , Irino , O. , Yamamoto , T. , Nishimura , N. , Taguchi , A. , Okada , T. and Nakayama , M. 1980 . J. Med. Chem. , 23 : 1324 and the references cited therein.
  • Yasamato , M. , Yamawaki , I. , Marunaka , T. and Hashimato , S. 1978 . J. Med. Chem , 21 : 738
  • Fox , J. J. and Wempen , I. 1959 . Advan Carbohydrate Chem. , 14 : 283
  • Baker , B. R. and Jackson , G. D. F. 1965 . J. Pharm. Sci. , 54 : 1758
  • Shugar , D. and Fox , J. J. 1952 . Biochim Biophys Acta. , 9 : 199
  • Sanyal , U. , Dutta , S. , Banerjee , S. and Chakraborti , S. K. 1982 . Ind. J. Chem. , (in press.)
  • After heating for the specified time, the solvent was spin-evaporated in vacuo. The residue was extracted with CHCl3-EtOAc (1:1), washed with brine and dried over anhydrous Na2SO4. The solvent mixture was concentrated under vacuum to afford the crude material
  • All the yields reported in this paper are calculated based on the amount of halides
  • Satisfactory analytical data (within ± 0.4%) were obtained for all the new compounds described. 1HNMR spectra were recorded in a Varian T-60A spectrometer with tetramethylsilane as internal standard. GLC experiments were carried out in a Hewlett-Packard gas chromatograph model 5730A using the column 10% UCW-982 on DMCS (100–120 mesh)
  • Kundu , N. G. , Hertzberg , R. P. and Hannon , S. J. 1980 . Tetrahedron Lett. , 21 : 1109

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