References
- Evans , D. A. , Truesdale , L. K. and Carroll , G. L. J. 1973 . Chem. Soc. Chem. Commun. , 55.
- Reactions carried out without silica gel were considerably slower and less clean. Some care is required to prevent further hydrolysis to the unstable cyanohydrin.
- Hangauer , W. J. 1983 . D. G. Tetrahedron Lett. , 24 : 4559 Recent examples of catalyzed reactions of α-keto esters with TMSCN: GreenleeMukaiyama, T.; Oriyama, T.; Murakami, M. Chemistry Lett. 1983, 985 and reference 5.
- The first step in the reaction of 3 with TMSCN, with or without a catalyst, involves the formation of the TMS enol ether i and HCN. Work is underway to delineate the mechanism of the conversion of i into either 4 or 2.
- Ojima , I. and Inaba , S. 1978 . Chem. Abstr. , 89 : 109942x . Japan. Kokai 78 34,729.
- This is contribution UNH NP-JR-SG-84-9 from the University of New Hampshire Sea Grant Program.