References
- Smith , R. and Livinghouse , T. 1983 . J. Org. Chem. , 48 : 1554
- Vedejs , E. and Martinez , G. R. 1980 . J. Am. Chem. Soc. , 102 : 7993
- Livinghouse , T. and Smith , R. 1983 . J. Chem., Soc., Chem. Commun. , : 210
- West , R. and Gornowitz , G. A. 1970 . J. Organometal, Chem. , 25 : 385
- The substitution of alternate low boiling ether solvents (e.g. diethyl ether) lead to inferior yields of the isocyanide 3. In the case of diethyl ether, the low yield of 3. is a direct consequence of the inability to metalate methyl isocyanide in this solvent at -78°C
- The execution of this preparation on a smaller scale (e.g. 50mmol) allows yields of 70%–85% to be obtained
- Attempts to utilize other copper catalysts (e.g. Cu, Cu20, and Cu(acac)2) to effect the insertion reaction between amines and the isocyanide 3. lead to a much greater proportion of products arising from desilylation of 3