A New Route to 4-(2-Methoxyethyl) Phenol Via Palladium-Catalysed Arylation of Methyl Vinyl Ether

References

• Hallberg , A. , Westfelt , L. and Holm , B. 1981 . J. Org. Chem. , 46 : 5414
   Web of Science ®Google Scholar
• Hallberg , A. and Westfelt , L. J. Chem. Soc. Perkin Trans. I , 1984 933
   Google Scholar
• For selected methods for preparation of 3, see:
   Google Scholar
• Lundmark , H. K. , Knott , D. M. , Sjöberg , K. and Åkermark , B. E. Belg. Pat. . 885,030 . 1980 . Chem. Abstr., 1981, 95, 115027t
   Google Scholar
• Baron , M. , Chignac , M. , Grain , C. and Pigerol , C. Fr. Demande FR . 2,487,336 . 1982 . Chem. Abstr., 1982, 97, 5973g
   Google Scholar
• Baron , M. , Chignac , M. , Grain , C. and Pigerol , C. Fr. Demande FR . 2,487,339 . 1982 . Chem. Abstr., 1982, 97, 5974h
   Google Scholar
• Baron , M. , Chignac , M. , Grain , C. and Pigerol , C. Fr. Demande FR . 2,487,338 . 1982 . Chem. Abstr., 1982, 97, 23451q
   Google Scholar
• Baron , M. , Chignac , M. , Grain , C. and Pigerol , C. Fr. Demande FR . 2,487,337 . 1982 . Chem. Abstr., 1982, 97, 23452r
   Google Scholar
• Koch-Weser , J. 1979 . The New England Journal of Medicin , 301 : 698 and references therein.
   PubMed Web of Science ®Google Scholar
• Butyl vinyl ether was shown to behave identically with methyl vinyl ether, and was used for most of the experiments due to ease of handling.
   Google Scholar
• Spencer , A. 1983 . J. Organomet. Chem. , 258 : 101 It has recently been reported that very high turnover numbers can be achieved for bromobenzene in Heck arylations, with sodium acetate as the base and triarylphosphine as ligand in dimethylformamide
   Web of Science ®Google Scholar
• Omitting the ligand improved the conversion and the regio-chemistry to some extent, but also gave extensive tar formation.
   Google Scholar
• Jeffery , T. J. Chem. Soc. Chem. Commun. , 1984 1287 Normally, elevated temperatures are required for the arylation. A modification, utilizing phase transfer techniques, gave excellent yields when applied to iodobenzene, even at room temperature
   Google Scholar
• Baird , R. and Winstein , S. 1963 . J. Am. Chem. Soc. , 85 : 567
   Web of Science ®Google Scholar