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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 18, 1988 - Issue 6
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Original Articles

A Short Synthesis of 4-Ketopipecolic Acid Hydrochloride

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Pages 553-557 | Published online: 05 Dec 2006

References

  • Münster , P. and Steglich , W. 1987 . Synthesis , : 223 See: and references cited therein
  • Seebach , D. 1983 . Modern Synthetic Methods , Edited by: Scheffold , R. 217 Frankfurt a.M. and Aarau : Salle & Sauerländer . For an authoritative article on titanium mediated reactions, see
  • Kessler , H. , Kühn , M. and Löschner , T. 1986 . Liebigs. Ann. Chem. , : 1 See: and references cited therein. The same authors synthesized 4-ketopipecolic acid methylester hydrobromide from the corresponding 4-hydroxy-compound in optically pure form
  • Kerwin , J. F. Jr. and Danishefsky , S. 1981 . Tetrahedron Lett. , 22 : 4607 for a review article on aza-Diels-Alder-reactions, see also S.M. Weinreb, J.I. Levin; Heterocycles 1979, 7, 949
  • This cycloaddition also takes place under basic conditions at room temperature employing 1 as well as under thermic conditions employing another electrophilic glycine equivalent6 in high yield
  • Jung , M. E. , Shishido , K. , Light , L. and Davis , L. 1981 . Tetrahedron Lett. , 22 : 4607
  • Seebach , D. , Beck , A. K. , Imwinkelried , R. , Roggo , S. and Wonnacott , A. 1987 . Helv. Chim. Acta , 70 : 954
  • Still , W. C. , Kahn , M. and Mitra , A. 1987 . J. Org. Chem. , 43 : 2923

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