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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 19, 1989 - Issue 1-2
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Original Articles

A Facile Preparation of Highly Substituted ß-Ketoamides

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Pages 59-62 | Received 02 Jun 1988, Published online: 24 Oct 2006

References

  • Gates , P. A. and Dawson , E. A. 1981 . Eur. Pat. , 24, 872 : 11 For example, see Mar
  • DeShong , P. , Lowmaster , N. E. and Baralt , O. 1983 . J. Org. Chem. , 48 : 1149 For example, see;or Hishmat, O. H.; Gohar, A.-K.; Wassef, M. E.; Shalash, M. R.; Ismail, I. Pharm. Acta Helv. 1977, 52, 252.
  • Reisch , J. and Niemeyer , D. 1968 . Tetrahedron Lett. , 26 : 3247
  • Reisch , J. and Niemeyer , D. 1971 . Tetrahedron , 27 : 4637
  • Tirpak , R. E. , Olsen , R. S. and Rathke , M. W. 1985 . J. Org. Chem. , 50 : 4877 Olsen, R. S.; Fataftah, Z. A.; Rathke, M. W. Synth. Commun. 1986, 16, 1133.
  • Based on representative yields of 50–75% for each alkylation an overall yield of 25–56% for two steps is calculated.
  • Zook , H. D. , Russo , T. J. , Ferrand , E. F. and Stotz , D. S. 1968 . J. Org. Chem. , 33 : 2222
  • These products may result from a further reaction of an initially formed ß-ketoamide.
  • Chadwich , D. H. and Cleveland , T. H. 1981 . Kirk-Othmer Encyclopedia of Chemical Technology, , 3rd edn. , Vol. 13 , 794 New York : Wiley .

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