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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 22, 1992 - Issue 7
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Original Articles

A Simple, High-Yielding Synthesis of N-t-Butoxycarbonyl α-Amino Esters: Precursors for α-Amino Aldehydes

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Pages 979-985 | Received 14 Oct 1991, Published online: 24 Sep 2006

References

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  • The ester hydrochlorides are normally obtained in apparent yields of 105–1157. (mass balance). Scrupulous removal of excess methanolic HCl is not necessary as an excess of TEA is used in the subsequent carbamylation
  • In the cases of L-serine and L-cysteine, ethyl acetate was used in the extraction step

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