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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 22, 1992 - Issue 20
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Original Articles

Synthesis of Enantiopure N-tert-Butoxycarbonyl-2-aminocycloalkanones

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Pages 3003-3012 | Received 09 Jun 1992, Published online: 23 Sep 2006

References

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  • Optical rotations of 5 from the DIBAH reduction of 6 were taken after flash chromatography but without subsequent recrystallization in order to avoid enantiomeric enrichment in the purification process.
  • For general experimental details, see reference 1b.
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  • It is necessary to perform the chromatographic purification via suction filtration. Lengthy chromatographic procedures result in significant loss of optical activity.

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