N-Alkylated 2-Trifluoromethyl-4-quinolones by Addition of Base and an Alkylating Agent to 2-Trifluoroacetylaminoacetophenones

Donald W. Combs The R. W. Johnson Pharmaceutical Research institute, Route 202, P.O. Box 300, Raritan, NJ, 08869-0602

Marianne S. Reed The R. W. Johnson Pharmaceutical Research institute, Route 202, P.O. Box 300, Raritan, NJ, 08869-0602

Dieter H. Klaubert The R. W. Johnson Pharmaceutical Research institute, Route 202, P.O. Box 300, Raritan, NJ, 08869-0602

References

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All of the trifluoroacetylaminoacetophenones were prepared by dissolving the appropriate aniline in excess trifluoroacetic anhydride at 10[ddot]C and warming to room temperature. The solvent was evaporated and the residue recrystallized from ethanol or ether
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Bajwa , G. S. and Joullie , M. M. 1972 . J. Het. Chem. , : 1403
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N-Alkylated 2-Trifluoromethyl-4-quinolones by Addition of Base and an Alkylating Agent to 2-Trifluoroacetylaminoacetophenones

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N-Alkylated 2-Trifluoromethyl-4-quinolones by Addition of Base and an Alkylating Agent to 2-Trifluoroacetylaminoacetophenones

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