Metalated Aromatic Carboxylic Acids: Improved Synthesis of SDZ HUL412

References

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• The overall yield of methyl ester 2 determined from Table II, entry 2 is 50%.
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• Further development of this reaction sequence for large scale applications is currently under investigation and the results will be reported at a later date.
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• The authors wish to thank Mr. Jerome Linder for his contribution in the hydrogenation reaction . 4 to 2
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