REFERENCES
- Creger , P. L. 1967 . J. Amer. Chem. Soc. , 89 : 2500
- 1970 . J. Amer. Chem. Soc. , 92 : 1396 and 1397
- Hildebran , K. C. , Cordray , T. L. , Chan , K. W. and Beam , C. F. 1994 . Synthetic Communications , 24 : 779
- Chemical Abstracts currently names these materials as 2-(2-oxo-2-phenylethyl)benzoic acids. Their former reference was α-benzoyl-o-toluic acids. Other names used for these compounds have included o-phenacylbenzoic acids. We are using the latter designation. In addition, 1H-2-benzopyranon-1-ones are referred to as isocoumarins, and 1-oxo-2,5-dihydro 1H-2,3-benzodiazepines are referred to as 2,3-benzodiazepin-1-ones in this paper.
- Shriner , R. L. and Knox , W. R. 1951 . J. Org. Chem. , 16 : 1064
- Buu-Hoi , N. P. 1944 . Bull. Soc Chim. France , 11 : 338
- Tsuge , A. , Hashimoto , I. , Matsuda , T. , Nagano , Y. and Tashiro , M. 1992 . Sogo Rikogaku Kenkyuka Hokoku , 13 : 357 Chem. Abstr. 1992, 117: 48040z
- Legrand , L. and Lozac'h , N. 1964 . Bull. Soc. Chim. France , : 1787
- Horeau , A. and Jacques , J. 1948 . Bull. Soc. Chim. France , : 53
- Sinha , N. K. , Sahay , L. K. , Prasad , K. and Srivastava . 1992 . Indian J. Heterocycl. Chem. , 1 : 235
- Kulkarni , S. U. and Usgaonkar . 1991 . J. Indian Chem. Soc. , 68 : 526
- Berti , G. 1959 . J. Org. Chem. , 24 : 934
- Sugimoto , T. , Nakamura , Najima , M. and Kusabayashi . 1991 . J. Org. Chem. , 56 : 1672
- Beam , C. F. , Sandifer , R. M. , Foote , R. S. and Hauser , C. R. 1976 . Synthetic Communications , 6 : 5
- Fulmer , T. D. , Dasher , L. P. , Bobb , B. L. , Wilson , J. D. , Sides , K. L. and Beam , C. F. 1980 . J. Heterocycl. Chem. , 17 : 799
- Livingston , M. J. , Chick , M. F. , Shealy , E. O. , Park , D. J. , Fulmer , T. D. and Beam , C. F. 1982 . J. Heterocycl. Chem. , 19 : 215
- Duncan , D. C. , Trumbo , T. A. , Almquist , C. D. , Lentz , T. A. and Beam , C. F. 1987 . J. Heterocycl. Chem. , 24 : 555
- Mazat , C. L. , Beam , C. F. and Hines , M. A. 1990 . Synthetic Communications , 20 : 253
- Davis , J. G. , Hines , M. A. , Griffith , C. L. and Beam , C. F. 1993 . Synthetic Communications , 23 : 201
- o-Toluic acid and esters were obtained from Aldrich Chemical Co.
- o-Phenacylbenzoic acid (1.00 gram) was dissolved in hot glacial acetic acid (10–15 mL), and then treated with 5–10 drops of concentrated sulfuric acid. The color of the solution darkened immediately and after 2 minutes of heating and stirring, the solution was poured into a beaker containing approximately 100 g. of ice. After the ice melted, the mixture containing solid material was filtered, and the resulting solid isocoumarin was recrystallized from alcohol or alcohol and water. See also:
- Allen , C. H. and Van Allan , J. A. 1948 . J. Amer. Chem. Soc. , 70 : 2069
- Koelsh , CF and LeClaire , CD. 1943 . J. Amer. Chem. Soc. , 65 : 754
- Beautement , K. and Clough , J. M. 1984 . Tetrahedron Lett. , 25 : 3025
- Brahmbhatt , D. I. and Bhidc , B. H. 1984 . Indian J. Chem. , 23B : 889
- o-Phenacylbenzoic acid (1.00 g.) was mixed with 1.00 g. of methylhydrazine, [5 drops of water] 10–15 mL of 2-ethoxyethanol, and heated under reflux overnight (12 hr. minimum, solution occurred). After evaporation of the 2-ethoxyethanol solvent, the resulting solid was recrystallized from ethanol. See also:
- Ames , D. A. and Dodds . 1972 . J. Chem. Soc., Perkin Trans. , 1 : 705
- Wolbling , H. 1905 . Ber. , 38 : 3846
- Wolbling , H. 1905 . Ber. , : 2845
- Flammang , M. and Hebd , C. R. 1978 . Seances Acad. Sci. Ser. C , 286 : 671 Chem. Abstr. 1978, 89: 146878b
- Flammang , M. and Wermuth , C. G. 1977 . Eur. J. Med. Chem.-Chim. Ther. , 12 : 121
- Flammang , M. , Wermuth , C. G. and Hebd , C. R. 1980 . Seances Acad. Sci. Ser. C , 290 : 361 Chem. Abstr. 1980, 93: 203556d
- Rose , A. and Buu-Hoi , N. P. 1968 . J. Chem. Soc. , C : 2205
- Vorozhtov , N. N. and Petuchkova , A. T. 1957 . J. Gen Chem. USSR (Engl. Trans.) , 27 : 2342
- Somei , M. , Karasawa , Y. , Shoda , T. and Kaneko , C. 1981 . Chem. Pharm. Bull., Japan. , 29 : 249
- Grogan , F. , O'Brian , A. E. , Philbin , E. M. , O'Conner , N. S. , Tommoney , R. F. and Wheeler , T. S. 1958 . Tetrahedron , 3 : 140
- Legrand , L. and Lozac'h , N. 1970 . Bull. Soc. Chim. Fr. , : 2237 and 2240
- The principal electrophilic reagent used in the condensation is monolithiated 2- or 4-hydroxybenzoate.
- Microanalysis for C, H, and N, when applicable were obtained from Quantitative Technologies, Inc., Box 470, Salem Industrial Park, Whitehouse, NJ 08888 [Compd. No. from Table]. Calcd. for 2, C17H16O5.H2O (C17H18O6): C, 64.14; H, 5.70. Found: C, 64.13; H, 5.65. Calcd. for 3: C, 70.31; H, 4.72. Found: C, 70.22; H, 4.72. Calcd. for 4: C, 70.31; H, 4.72. Found: C, 70.18; H, 4.90. Calcd. for 5: C, 65.58; H, 4.04. Found: C, 65.82; H, 4.27. Calcd for 6: C, 77.00; H, 6.80. Found: C, 76.84; H, 6.69. Calcd. for 7: C, 67.99; H, 5.37. Found: C, 67.74; H, 5.35. Calcd. for 8: C, 61.98; H, 3.81. Found: C, 62.12; H, 3.75. Calcd. for 9: C, 65.45; H, 5.49. Found: C, 65.59; H, 5.65. Calcd. for 10, C16H13CIO4.H2O (C16H15ClO5): C, 59.54; H, 4.68. Found: C, 59.51; H, 4.80. Calcd. for 11: C, 69.22; H, 5.16. Found: C, 68.98; H, 5.17. Calcd. for 12: C, 67.03; H, 3.87. Found: C, 66.95; H, 3.73. Calcd. for 13: C, 69.66; H, 5.85; N, 9.03. Found: C, 69.42; H, 5.87; N, 8.96. Calcd. for 14: C, 72.17; H, 5.30; N, 10.52. Found: C, 72.03; H, 5.19; N, 10.29.
- Infrared spectra were obtained from a Mattson Polaris FT-Infrared Spectrometer. Each compound 1–10 displayed less defined but somewhat characteristic OH absorptions observed for carboxylic acids between 3400–3200 and 2700 -2500 cm−1. 1H nmr for 1 and 4 – 14 were obtained from a Varian Associates, EM-360L and 1 and 3 from a EM-360A Nuclear Magnetic Resonance Spectrometers, and chemical shifts are reported in δ ppm downfield from an internal tetramethylsilane (TMS) standard. [Compd. No.: ir (paraffin oil), cm−1; 1H nmr (solvent), δ ppm] Compd. 1: ir, 3150 (broad, OH), 1687 (C=O-O), and 1672 (C=O-CH2); nmr (CDCl3/DMSO-d6), 4.86 (s, CH2-C=O) and 7.20–8.37 (m, AH). Compd. 2: ir, 3509 and 3430 (OH), 1711 (C=O-O), and 1672 (C=O-CH2; nmr (CDCl3/DMSO-d6), 3.85 (s, OCH3), 4.70 (s, CH2-C=O), 6.58 (s, vinyl), 7.15–7.67 (m, ArH), and 8.15 (s broad, OH). Compd. 3: ir, 3101 (broad, OH), 1693 (C=O-O), and 1682 (C=O-CH2); nmr (DMSO-d6), 4.90 (s, CH2-C=O) and 7.13 - 8.27 (m, ArH). Compd. 4: ir, 3174 (OH), 1726 (C=O-O), and 1651 (C=O-CH2); nmr (DMSO-d6), 4.70 (s, CH2-C=O) and 6.73–8.20 (m, ArH, vinyl - enol, COOH). Compd. 5: ir, 1689 and 1681 (C=O-O and C=O-CH2); nmr (CDCl3), 4.63 (s, CH2-C=O) and 7.10–8.27 (m, ArH and COOH). Comp. 6: ir, 1691 (shoulders, C=O-O and C=O-CH2); nmr (CDCl3/DMSO-d6), 1.37 (s, Ar-C(CH3)3), 4.68 (s, CH2-C=O2), and 7.07 - 8.33 (m, ArH and COOH). Compd. 7: ir, 1674 (shoulders, C=O-O and C=O-CH2); nmr (CDCl3/MSO-d6), 3.87 and 3.90 (s, ArOCH3), 4.70 (s, CH2-C=O), and 6.18–8.18 (m, ArH, vinyl - enol, COOH). Compd. 8: ir, 1684 and 1645 (shoulders, C=O-O and C=O-CH2); nmr (CDCl3/DMSO-d6), 4.78 (s, CH2-C=O2) and 6.83 - 8.30 (m, ArH and COOH). Compd. 9: ir, 1700 (C=O-O); nmr (CDCl3/DMSO-d6), 3.92 and 3.95 (s, ArOCH3), 7.40 - 8.33 (m, ArH), and 8.68 (s, COOH - exchange with D2O). Compd. 10: ir, 3438 (OH), 1693 (C=O-O), and 1666 (C=O-CH2); nmr (CDCl3/DMSO-d6), 3.93 (s, ArOCH3), 4.62 (s, CH2-C=O), and 6.93 - 8.18 (m, ArH and COOH). Compd. 11: ir, 1734 (C=O); nmr (DMSO-d6), 3.92 (s broad, ArOCH3) and 7.23 - 8.42 (m, C4-H and ArH). Compd. 12: ir, 1724 (C=O); nmr (CDCl3), 3.95 (s, ArOCH3), and 6.82–8.40 (m, C4H and ArH). Compd. 13: ir, 1644 (C=O-N); nmr (CDCl3), 3.65 (s, N-CH3), 3.85 (s, ArOCH3), 3.95 (s, -CH2-), and 6.51 8.18 (m, ArH). Compd. 14: ir, 1635 (C=O-N); nmr (DMSO-d6), 3.55 (s, N-CH3), 4.22 (s, -CH2-), and 6.77 -8.05(m, ArH).
- Hotta , H. , Tejima , S. , Nakamura , K. and Hatsutori , M. Jpn. Kokai Tokkyo, Koho JP . 61, 213, 280 . 1986 . Chem. Abstr. 1987, 106: P 55651a