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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 26, 1996 - Issue 7
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Original Articles

Synthesis of N-t-Boc-4-S-t-Butyl-L-thiophenylalanine via Palladium Catalyzed Cross-Coupling Reaction of N-t-Boc-4-Iodo-L-phenylalanine with t-Butylthiol or Sodium t-Butylthiolate

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Pages 1431-1440 | Received 30 Sep 1995, Published online: 15 Aug 2006

References and Notes

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  • We thank Prof. Escher for sending us some of the thiophenylalanine samples synthesized using the procedure in ref 13 and for sharing with us their experience in carrying out that synthesis
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  • HPLC Assay: Column: PLRP-S (50 × 7.5 mm); A=H2O (0.1%CF3COOH); B=90:10 CH3CN/H2O (0.1% CF3COOH); detection at 260 nm; flow rate 2 mL/min. linear gradient program: 1% to 90% B in 30 min. tR 2 = 23.8 min and 3 = 26.3 min.
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