Efficient Two-Step Syntheses of Sulfonylguanidines from Sulfonamides

References

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• Sulfonylguanidines 5a-e, after saponification of the 5-ethyl ester on the imidazole ring, have been evaluated in vitro for their affinity for the AT1 receptor (ability to displace [125I]AII from its binding sites in rat liver membrane preparation)1. If they proved to be 5 to 10-fold less potent than the corresponding sulfonylurea HR 720, their in vitro potency was in similar range (2 - 5 nmol) to that of DuP 753, the only All antagonist on the market at the moment
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