Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 27, 1997 - Issue 2
141
Views
8
CrossRef citations to date
0
Altmetric
Original Articles

Simple and Efficient Conversion of Colchicine into Deacetylcolchicine

, &
Pages 293-296 | Received 16 Jul 1996, Published online: 22 Aug 2006

References

  • Chemnitius , F. 1928 . J. Prakt. Chem. [II] , 118 : 29 – 32 .
  • For recent reviews see: (a) Hastie S. B. Pharmacol. Ther. 1991 51 377 401
  • Hamel , E. 1990 . Microtubule Proteins , Edited by: Avila , J. 89 – 191 . Boca Raton, F1 : CRC Press .
  • Brossi , A. , Yeh , H. J.C. , Chrzanowska , M. , Wolff , J. , Hamel , E. , Lin , C. M. , Quin , F. , Suffness , M. and Silverton , J. 1988 . J. Med. Res. Rev. , 8 : 77 – 94 .
  • Boye , O. and Brossi , A. 1992 . The Alkaloids , Edited by: Brossi , A. and Cordell , G. A. Vol, 41 , 125 – 176 . New York : Academic Press .
  • Lebeau , L. , Schultz , P. , Célia , H. , Mésini , P. , Nuss , S. , Klinger , C. , Olland , S. , Oudet , P. and Mioskowski , C. 1996 . Non-medical applications of liposomes – Models for biological phenomena , Edited by: Barenholtz , Y. and Lasic , D. D. Vol 2 , 153 – 186 . Boca Raton, Fl : CRC Press .
  • Hinman , N. D. and Morgan , J. L. 1973 . Biochem. Biophys. Res. Commun. , 52 : 752 – 758 .
  • Fernholz , H. 1953 . Angew. Chem. , 65 : 319
  • Wilson , L. and Friedkin , M. 1966 . Biochem. , 5 : 2463 – 2468 .
  • Raffauf , R. F. , Farren , A. L. and Ullyot , G. E. 1953 . J. Am. Chem. Soc. , 75 : 5292 – 5294 .
  • Modelli , R. and Vercellone , A. 1955 . Farmaco (Pavia) Ed. Sci. , 10 : 877 – 882 .
  • Dumont , R. , Brossi , A. and Silverton , J. V. 1986 . J. Org. Chem. , 51 : 2515 – 2521 .
  • Compound 5:1H-RMN (CDCl3, 200 MHz) 7.54 (s, 1H); 7.17 (d, J = 10.6 Hz, 1H); 6.73 (d, J = 10.6 Hz. 1H); 6.51 (s. 1H); 5.12 (dd, J = 5.8, 11.9 Hz, 1H); 3.94 (s, 3H); 3.90 (s. 3H); 3.87 (s. 3H); 3.63 (s, 3H); 2.70–2.37 (m, 3H); 2.25 (s, 3H); 2.02–1.84 (m, 1H); 1.53 (s. 9H).
  • Flynn , D. L. , Zelle , R. E. and Grieco , P. A. 1983 . J. Org. Chem. , 48 : 2424 – 2426 .
  • Compound 6:1H-RMN (CDCl3, 200 MHz): 7.49 (s, 1H); 7.23 (d, J = 10.7 Hz, 1H); 6.79 (d. J = 10.7 Hz, 1H); 6.51 (s. 1H); 5.06 (d. J = 7.6 Hz, 1H); 4.42–4.35 (m, 1H); 3.97 (s, 3H); 3.90 (s, 3H); 3.87 (s, 3H); 3.62 (s, 3H); 2.51–2.16 (m, 3H); 1.72–1.63 (m, 1H); 1.33 (s, 9H).
  • Haas , W. L. , Krumkalns , E. V. and Gerzon , K. 1966 . J. Am. Chem. Soc. , 88 : 1988 – 1992 .
  • Capraro , H. G. and Brossi , A. 1979 . Helv. Chim. Acta , 62 : 965 – 970 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.