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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 28, 1998 - Issue 24
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Original Articles

An Efficient Synthesis of 2-(((9-Fluorenylmethoxycarbonyl)amino)methyl)benzoic Acid

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Pages 4525-4530 | Received 08 Jun 1998, Published online: 22 Aug 2006

References and Notes

  • Hutchins , S. M. and Chapman , K. T. 1995 . Tetrahedron Lett , 36 : 2583
  • Smythe , M. L. and von Itzstein , M. 1994 . J. Am. Chem. SOC. , 776 : 2725
  • Wegscheder , R. and Glogau , A. 1903 . Monatsh. Chern. , 24 : 953
  • Mix , H. , Trettin , H.-J. , Gulzow , M. and Hoppe-Seyler's , Z. 1965 . Physiol. Chem. , 343 : 52
  • Young , A and Sweet , T. R. 1958 . J. Am. Chem. SOC. , 80 : 800
  • 2-Cyanobenzoic acid was prepared from phthalic anhydride in 3 steps (see reference 5).
  • Under the same reaction conditions, 3-cyanobenzoic acid and 4-cyanobenzoic acid were reduced to 3-aminobenzylamine and 4-aminobenzylamine hydrochloride in 70% and 75% yield, respectively.
  • Platinum oxide can be purchased from Aldrich for $291.40/5 grams; 2-cyanobenzoic acid is available from ICN for $92.50/10 grams.
  • Bornstein , J , Drummond , P. E. and Bedell , S. F. 1963 . Org. Syn. Collective , Vol. lV : 810

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