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Original Articles

The Biological Underpinnings of Peer Victimization: Understanding Why and How the Effects of Bullying Can Last a Lifetime

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Pages 241-248 | Published online: 04 Oct 2013

References

  • American Psychiatric Association . 2000 . Diagnostic and statistical manual of mental disorders, , 4th ed., text rev. Washington , DC : Author. .
  • Beach , S. R. H. , Brody , G. H. , Todorov , A. A. , Gunter , T. D. and Philibert , R. A. 2010 . Methylation at SLC6A4 is linked to family history of child abuse: An examination of the Iowa adoptee sample . American Journal of Medical Genetics Part B: Neuropsychiatric Genetics , 153B : 710 – 713 .
  • Benjet , C. , Thompson , R. J. and Gotlib , I. H. 2010 . 5-HTTLPR moderates the effect of relational peer victimization on depressive symptoms in adolescent girls . Journal of Child Psychology and Psychiatry , 51 : 173 – 179 .
  • Bick , J. , Naymova , O. , Hunter , S. , Barbot , B. , Lee , M. , Luthar , S. S. and Grigorenko , E. L. 2012 . Childhood adversity and DNA methylation of genes involved in the hypothalamus–pituitary–adrenal axis and immune system: Whole-genome and candidate-gene associations . Development and Psychopathology , 24 : 1417 – 1425 .
  • Bonanno , R. A. and Hymel , S. 2010 . Beyond hurt feelings: Investigating why some victims of bullying are at greater risk for suicidal ideation . Merrill-Palmer Quarterly , 56 : 420 – 440 .
  • Bremner , J. D. and Vermetten , E. 2001 . Stress and development: Behavioral and biological consequences . Development and Psychopathology , 13 : 473 – 489 .
  • Card , N. A. , Isaacs , J. and Hodges , E. V. E. 2007 . “ Correlates of school victimization: Implications for prevention and intervention. ” . In Bullying, victimization, and peer harassment: A handbook of prevention and intervention Edited by: Zins , J. E. , Elias , M. J. and Maher , C. A. 339 – 366 . New York , NY : Haworth. .
  • Caspi , A. , Sugden , K. , Moffitt , T. E. , Taylor , A. , Craig , I. W. , Harrington , H. and Poulton , R. 2003 . Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene . Science , 301 : 386 – 389 .
  • Chen , Z. , Williams , K. D. , Fitness , J. and Newton , N. C. 2008 . When hurt will not heal: Exploring the capacity to relive social and physical pain . Psychological Science , 19 : 789 – 795 .
  • Eisenberger , N. I. 2012 . The pain of social disconnection: Examining the shared neural underpinnings of physical and social pain . Nature Reviews Neuroscience , 13 : 421 – 434 .
  • Epel , E. S. , Blackburn , E. H. , Lin , J. , Dhabhar , F. S. , Adler , N. E. , Morrow , J. D. and Cawthon , R. M. 2004 . Accelerated telomere shortening in response to life stress . PNAS , 101 : 17312 – 17315 .
  • Gini , G. and Pozzoli , T. 2009 . Association between bullying and psychosomatic problems: A meta-analysis . Pediatrics , 123 : 1059 – 1065 .
  • Hansen , A. M. , Hogh , A. , Persson , R. , Karlson , B. , Garde , A. H. and Ørbæk , P. 2006 . Bullying at work, health outcomes, and physiological stress response . Journal of Psychosomatic Research , 60 : 63 – 72 .
  • Hölzel , B. K. , Carmody , J. , Evans , K. C. , Hoge , E. A. , Dusek , J. A. , Morgan , L. and Lazar , S. W. 2010 . Stress reduction correlates with structural changes in the amygdala . SCAN , 5 : 11 – 17 .
  • Hölzel , B. K. , Carmody , J. , Vangel , M. , Congleton , C. , Yerramsetti , S. M. , Gard , T. and Lazar , S. W. 2011 . Mindfulness practice leads to increase in regional brain gray matter density . Psychiatry Research: Neuroimaging , 191 : 36 – 43 .
  • Idsoe , T. , Dyregrov , A. and Idsoe , E. C. 2012 . Bullying and PTSD symptoms . Journal of Abnormal Child Psychology , 40 : 901 – 911 .
  • Karg , K. , Burmeister , M. , Shedden , K. and Sen , S. 2011 . The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: Evidence of genetic moderation . Archives of General Psychiatry , 68 : 444 – 454 .
  • Kiecolt-Glaser , J. K. , Gouin , J. P. , Weng , N-P. , Malarkey , W. B. , Beversdorf , D. Q. and Glaser , R. 2011 . Childhood adversity heightens the impact of later-life caregiving stress on telomere length and inflammation . Psychosomatic Medicine , 73 : 16 – 22 .
  • Kimura , M. , Hjelmborg , J. V. B. , Gardner , J. P. , Bathum , L. , Brimacombe , M. , Lu , X. B. and Christensen , K. 2008 . Telomere length and mortality: A study of leukocytes in elderly Danish twins . American Journal of Epidemiology , 167 : 799 – 806 .
  • Kliewer , W. 2006 . Violence exposure and cortisol responses in urban youth . International Journal of Behavioral Medicine , 13 : 109 – 120 .
  • Knack , J. M. , Jensen-Campbell , L. A. and Baum , A. 2011 . Worse than sticks and stones? Bullying is linked with altered HPA axis functioning and poorer health . Brain and Cognition , 77 : 183 – 190 .
  • Knack , J. M. and Vaillancourt , T. 2012 . “ Evidence of altered cortisol levels across child maltreatment, intimate partner abuse and peer victimization. ” . In Psychology of victimization Edited by: Hutcherson , A. N. 205 – 218 . New York , NY : Nova Science. .
  • Lupien , S. J. , Fiocco , A. , Wan , N. , Maheu , F. , Lord , C. , Scramek , T. and Tu , M. T. 2005 . Stress hormones and human memory function across the lifespan . Psychoneuroendocrinology , 30 : 225 – 242 .
  • McDougall , P. and Vaillancourt , T. 2013 . The long-term outcomes of peer victimization in school: Pathways to adjustment and maladjustment. Manuscript submitted for publication
  • McGowan , P. O. , Sasaki , A. , D'Alessio , A. C. , Sergiy , D. , Labonté , B. , Szyf , M. and Meaney , M. J. 2009 . Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse . Nature Neuroscience , 12 : 342 – 348 .
  • Meaney , M. 2010 . “ Epigenetics and the environmental regulation of the genome and its function. ” . In Evolution, early experience and human development: From research to practice Edited by: Narvaez , D. , Panksepp , J. , Schore , A. N. and Gleason , T. R. 99 – 128 . New York , NY : Oxford University Press. .
  • Miller , G. E. , Chen , E. and Zhou , E. S. 2007 . If it goes up, must it come down? Chronic stress and the hypothalamic–pituitary–adrenocortical axis in humans . Psychological Bulletin , 133 : 25 – 45 .
  • Morris , M. C. , Compas , B. and Garber , J. 2012 . Relations among posttraumatic stress disorder, comorbid major depression, and HPA function: A systematic review and meta-analysis . Clinical Psychology Review , 32 : 301 – 315 .
  • Nakamoto , J. and Schwartz , D. 2010 . Is peer victimization associated with academic achievement? A meta-analytic review . Social Development , 19 : 221 – 242 .
  • Ouellet-Morin , I. , Danese , A. , Bowes , L. , Shakoor , S. , Ambler , A. , Pariante , C. M. and Arseneault , L. 2011 . A discordant monozygotic twin design shows blunted cortisol reactivity among bullied children . Journal of the Academy of Child & Adolescent Psychiatry , 50 : 574 – 582 .
  • Ouellet-Morin , I. , Wong , C. C. Y. , Danese , A. , Pariante , C. M. , Papadopoulos , A. S. , Mill , J. and Arseneault , L. 2012 . Increased serotonin transporter gene (SERT) DNA methylation is associated with bullying victimization and blunted cortisol response to stress in childhood: A longitudinal study of discordant monozygotic twins . Psychological Medicine , 43 : 1813 – 1823 .
  • Panksepp , J. 1998 . Affective neuroscience New York , NY : Oxford University Press. .
  • Resnick , H. S. , Yehuda , R. , Pitman , R. K. and Foy , D. W. 1995 . Effect of previous trauma on acute plasma cortisol level following rape . American Journal of Psychiatry , 152 : 1675 – 1677 .
  • Rudolph , K. D. , Troop-Gordon , W. and Granger , D. A. 2011 . Individual differences in biological stress responses moderate the contribution of early peer victimization to subsequent depressive symptoms . Psychopharmacology , 241 : 209 – 219 .
  • Rueger , S. Y. , Malecki , C. K. and Demaray , M. K. 2011 . Stability of peer victimization in early adolescence: Effects of timing and duration . Journal of School Psychology , 49 : 443 – 464 .
  • Shalev , I. , Moffitt , T. E. , Williams , B. , Houts , R. M. , Danese , A. , Mill , J. and Caspi , A. 2012 . Exposure to violence during childhood is associated with telomere erosion from 5 to 10 years of age: A longitudinal study . Molecular Psychiatry , April 24 : 1 – 6 .
  • Shea , A. , Walsh , C. , MacMillan , H. and Steiner , M. 2005 . Child maltreatment and HPA axis dysregulation: Relationship to major depressive disorder and post-traumatic stress disorder in females . Psychoneuroendocrinology , 30 : 162 – 178 .
  • Sugden , K. , Arseneault , L. , Harrington , H. , Moffit , T. E. , Williams , B. and Caspi , A. 2010 . Serotonin transporter gene moderates the development of emotional problems among children following bullying victimization . Journal of the Academy of Child & Adolescent Psychiatry , 49 : 830 – 840 .
  • Sugimura , N. and Rudolph , K. D. 2012 . Temperamental differences in children's reactions to peer victimization . Journal of Clinical Child & Adolescent Psychology , 41 : 314 – 328 .
  • Szyf , M. and Bick , J. 2013 . DNA methylation: A mechanism for embedding early life experiences in the genome . Child Development , 84 : 49 – 57 .
  • Tsankova , N. , Renthal , W. , Kumar , A. and Nestler , E. J. 2007 . Epigenetic regulation in psychiatric disorders . Nature Reviews Neuroscience , 8 : 355 – 367 .
  • Tyrka , A. R. , Price , L. H. , Kao , H-T. , Porton , B. , Marsella , S. A. and Carpenter , L. L. 2010 . Childhood maltreatment and telomere shortening: Preliminary support for an effect of early stress on cellular aging . Biological Psychiatry , 67 : 531 – 534 .
  • Vaillancourt , T. , Duku , E. , Becker , S. , Schmidt , L. , Nicol , J. , Muir , C. and MacMillian , H. 2011 . Peer victimization, depressive symptoms, and high salivary cortisol predict poor memory in children . Brain and Cognition , 77 : 191 – 199 .
  • Vaillancourt , T. , Duku , E. , deCatanzaro , D. , MacMillan , H. , Muir , C. and Schmidt , L. A. 2008 . Variation in hypothalamic–pituitary–adrenal axis activity among bullied and non-bullied children . Aggressive Behavior , 34 : 294 – 305 .
  • Vaillancourt , T. , Hymel , S. and McDougall , P. 2010 . “ Why does being bullied hurt so much? Insights from neuroscience. ” . In Bullying in North American Schools, , 2nd Ed. Edited by: Espelage , D. and Swearer , S. 23 – 33 . New York , NY : Taylor & Francis. .
  • van der Harst , P. , de Boer , R. A. , Samani , N. J. , Wong , L. S. , Huzen , J. , Codd , V. and van Veldhuisen , D. J. 2010 . Telomere length and outcome in heart failure . Annals of Medicine , 42 : 36 – 44 .
  • Vialou , V. , Feng , J. , Robison , A. J. and Nestler , E. J. 2013 . Epigenetic mechanism of depression and antidepressant action . Annual Review of Pharmacology and Toxicology , 53 : 59 – 87 .
  • Weaver , I. C. G. , Cervoni , N. , Champagne , F. A. , D'Alessio , A. C. , Sharma , S. , Seckl , J. R. and Meaney , M. J. 2004 . Epigenetic programming by maternal behavior . Nature Neuroscience , 7 : 847 – 854 .
  • Willeit , P. , Willeit , J. , Mayr , A. , Weger , S. , Oberhollenzer , F. , Brandstatter , A. and Kiechl , S. 2010 . Telomere length and risk of incident cancer and cancer mortality . Journal of the American Medical Association , 304 : 69 – 75 .
  • Wolf , O. T. 2003 . HPA axis and memory . Best Practice & Research Clinical Endocrinology and Metabolism , 17 : 287 – 299 .
  • Yehuda , R. , Kahana , B. , Binder-Brynes , K. , Southwick , S. M. , Mason , J. W. and Giler , E. L. 1995 . Low urinary cortisol excretion in Holocaust survivors with posttraumatic stress disorder . American Journal of Psychiatry , 152 : 982 – 986 .

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